Neoechinulins: Molecular, cellular, and functional attributes as promising therapeutics against cancer and other human diseases

Mitra, Sicon; Anand, Uttpal; Sanyal, Rupa; Jha, Niraj Kumar; Behl, Tapan; Mundhra, Avinash; Ghosh, Arabinda; Radha, .; Kumar, Manoj; Proćków, Jarosław; Dey, Abhijit

doi:10.1016/j.biopha.2021.112378

Cited by 38 publications

(8 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Various scientific reports are available that pointed to some of the anti-cancer activities of the aloins, especially the barbaloin. A study by Zhang et al (2017a, b) showed that different types of conventional treatment approaches for non-small cell lung carcinoma (NSCLC), one of the most common types of lung cancer, had their own set of side effects (Mitra et al 2022c ; Anand et al 2022b ). However, in contrast, cells treated with barbaloin because of its anti-cancer potential were found to inhibit metastasis and cell growth both in vitro and in vivo and without any side effects as traditional treatment methods (Anand et al 2020 ; Halder et al 2021 ).…”

Section: Medicinal Importance and Pharmacological Activities Of Barba...mentioning

confidence: 99%

RETRACTED ARTICLE: Barbaloin: an amazing chemical from the ‘wonder plant’ with multidimensional pharmacological attributes

Mitra

Ghorai

Nandy

et al. 2022

Naunyn-Schmiedeberg's Arch Pharmacol

Self Cite

View full text Add to dashboard Cite

Aloe vera (L.) Burm.f. is nicknamed the ‘Miracle plant’ or sometimes as the ‘Wonder plant’. It is a plant that has been used since ancient times for the innumerable health benefits associated with it. It is one of the important plants that has its use in conventional medicinal treatments. It is a perennial succulent, drought-tolerant member of the family Asphodelaceae. There are scores of properties associated with the plant that help in curing various forms of human ailments. Extracts and gels obtained from plants have been shown to be wonderful healers of different conditions, mainly various skin problems. Also, this plant is popular in the cosmetics industry. The underlying properties of the plant are now mainly associated with the natural phytochemicals present in the plant. Diverse groups of phytoingredients are found in the plant, including various phenolics, amino acids, sugars, vitamins, and different other organic compounds, too. One of the primary ingredients found in the plant is the aloin molecule. It is an anthraquinone derivative and exists as an isomer of Aloin A and Aloin B. Barbaloin belonging to the first group is a glucoside of the aloe-emodin anthrone molecule. Various types of pharmacological properties exhibited by the plant can be attributed to this chemical. Few significant ones are antioxidant, anti-inflammatory, anti-diabetic, anti-cancer, anti-microbial, and anti-viral, along with their different immunity-boosting actions. Recently, molecular coupling studies have also found the role of these molecules as a potential cure against the ongoing COVID-19 disease. This study comprehensively focuses on the numerous pharmacological actions of the primary compound barbaloin obtained from the Aloe vera plant along with the mechanism of action and the potent application of these natural molecules under various conditions.

show abstract

Section: Medicinal Importance and Pharmacological Activities Of Barba...mentioning

confidence: 99%

RETRACTED ARTICLE: Barbaloin: an amazing chemical from the ‘wonder plant’ with multidimensional pharmacological attributes

Mitra

Ghorai

Nandy

et al. 2022

Naunyn-Schmiedeberg's Arch Pharmacol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Antimicrobial peptides are components of innate immunity present in all classes of life [270,272,273]. Because of their electrostatic interactions with the negatively charged bacterial membrane, cationic peptides might exhibit antiproliferative effects targeted to cancer cells [274].…”

Section: Cddp and Peptidesmentioning

confidence: 99%

Cellular landscaping of cisplatin resistance in cervical cancer

Bhattacharjee

Dey

Kumar

et al. 2022

Biomedicine & Pharmacotherapy

Self Cite

View full text Add to dashboard Cite

“…A number of phytoconstituents have also been reported as promising disease modifying agents ( Bandopadhyay et al, 2021 ; Banerjee et al, 2021 ; Datta et al, 2021 ). Many investigations have also carried out to explore the pre-clinical and clinical efficacy of botanical-derived products ( Khare et al, 2021 ; Mitra et al, 2021 ; Mitra et al, 2022b ). However, COPD could be treatable if exposure to risk factors can be avoided ( Vogelmeier et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Unravelling the Therapeutic Potential of Botanicals Against Chronic Obstructive Pulmonary Disease (COPD): Molecular Insights and Future Perspectives

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background: COPD (chronic obstructive pulmonary disease) is a serious health problem worldwide. Present treatments are insufficient and have severe side effects. There is a critical shortage of possible alternative treatments. Medicinal herbs are the most traditional and widely used therapy for treating a wide range of human illnesses around the world. In several countries, different plants are used to treat COPD.Purpose: In this review, we have discussed several known cellular and molecular components implicated in COPD and how plant-derived chemicals might modulate them.Methods: We have discussed how COVID-19 is associated with COPD mortality and severity along with the phytochemical roles of a few plants in the treatment of COPD. In addition, two tables have been included; the first summarizes different plants used for the treatment of COPD, and the second table consists of different kinds of phytochemicals extracted from plants, which are used to inhibit inflammation in the lungs.Conclusion: Various plants have been found to have medicinal properties against COPD. Many plant extracts and components may be used as novel disease-modifying drugs for lung inflammatory diseases.

show abstract

Neoechinulins: Molecular, cellular, and functional attributes as promising therapeutics against cancer and other human diseases

Cited by 38 publications

References 76 publications

RETRACTED ARTICLE: Barbaloin: an amazing chemical from the ‘wonder plant’ with multidimensional pharmacological attributes

RETRACTED ARTICLE: Barbaloin: an amazing chemical from the ‘wonder plant’ with multidimensional pharmacological attributes

Cellular landscaping of cisplatin resistance in cervical cancer

Unravelling the Therapeutic Potential of Botanicals Against Chronic Obstructive Pulmonary Disease (COPD): Molecular Insights and Future Perspectives

Contact Info

Product

Resources

About