Unravelling the Therapeutic Potential of Botanicals Against Chronic Obstructive Pulmonary Disease (COPD): Molecular Insights and Future Perspectives

Abstract

Background: COPD (chronic obstructive pulmonary disease) is a serious health problem worldwide. Present treatments are insufficient and have severe side effects. There is a critical shortage of possible alternative treatments. Medicinal herbs are the most traditional and widely used therapy for treating a wide range of human illnesses around the world. In several countries, different plants are used to treat COPD.Purpose: In this review, we have discussed several known cellular and molecular components implicated in COPD and how plant-derived chemicals might modulate them.Methods: We have discussed how COVID-19 is associated with COPD mortality and severity along with the phytochemical roles of a few plants in the treatment of COPD. In addition, two tables have been included; the first summarizes different plants used for the treatment of COPD, and the second table consists of different kinds of phytochemicals extracted from plants, which are used to inhibit inflammation in the lungs.Conclusion: Various plants have been found to have medicinal properties against COPD. Many plant extracts and components may be used as novel disease-modifying drugs for lung inflammatory diseases.

RETRACTED ARTICLE: Barbaloin: an amazing chemical from the ‘wonder plant’ with multidimensional pharmacological attributes

“…The entire process of research based on natural products-based research surrounds the applicability of different naturally obtained molecules (Mitra et al 2022b ). But in reality, it calls for a lot of patience and endurance.…”

Scutellarein alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis by chelating iron and interacting with arachidonate 15‐lipoxygenase

“…Natural products have always been considered as an important source of the research and development of new drugs (Anand et al, 2019(Anand et al, , 2022Halder et al, 2021;Newman & Cragg, 2020). A large number of medicinal plants have been found to possess medicinal properties against COPD (Mitra et al, 2022). Natural flavonoids, the main active components of numerous medicinal plants, also have been proven to have therapeutic potential in COPD (Fu et al, 2022).…”

Identification and Pharmacological Activities of Secondary Metabolites of Phytochemicals

“…osteoporosis [44][45][46], cancers [47][48][49][50][51], chronic obstructive pulmonary diseases [52][53][54], diabetes [41,[55][56][57], diarrheal [58], respiratory problems [59], Human Immunodeficiency Virus (HIV) infection [13,[60][61][62], mental health problems [24,[63][64][65][66][67] etc.…”