Neodymium:YAG laser damage threshold of foldable intraocular lenses

Trinavarat, Adisak; Atchaneeyasakul, La-ongsri; Udompunturak, Suthipol

doi:10.1016/s0886-3350(00)00855-5

Cited by 34 publications

(28 citation statements)

References 6 publications

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“…To restore vision, Nd:YAG laser treatment is performed to remove the fibrotic tissue and clear the visual axis. The Nd:YAG laser treatment has side effects, including an increase in intraocular pressure (IOP), glaucoma, IOL damage, corneal edema, uveitis, cystoid macular edema and retinal detachment, although at a very low incidence [10,11]. Thus, efforts are underway to prevent PCO formation.…”

Section: Introductionmentioning

confidence: 99%

AGE-RAGE interaction in the TGFβ2-mediated epithelial to mesenchymal transition of human lens epithelial cells

Raghavan

Nagaraj

2016

Glycoconj J

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Basement membrane (BM) proteins accumulate chemical modifications with age. One such modification is glycation, which results in the formation of advanced glycation endproducts (AGEs). In a previous study, we reported that AGEs in the human lens capsule (BM) promote the TGFβ2-mediated epithelial-to-mesenchymal transition (EMT) of lens epithelial cells, which we proposed as a mechanism for posterior capsule opacification (PCO) or secondary cataract formation. In this study, we investigated the role of a receptor for AGEs (RAGE) in the TGFβ2-mediated EMT in a human lens epithelial cell line (FHL124). RAGE was present in FHL124 cells, and its levels were unaltered in cells cultured on either native or AGE-modified BM or upon treatment with TGFβ2. RAGE overexpression significantly enhanced the TGFβ2-mediated EMT responses in cells cultured on AGE-modified BM compared with the unmodified matrix. In contrast, treatment of cells with a RAGE antibody or EN-RAGE (an endogenous ligand for RAGE) resulted in a significant reduction in the TGFβ2-mediated EMT response. This was accompanied by a reduction in TGFβ2-mediated Smad signaling and ROS generation. These results imply that the interaction of matrix AGEs with RAGE plays a role in the TGFβ2-mediated EMT of lens epithelial cells and suggest that the blockade of RAGE could be a strategy to prevent PCO and other age-associated fibrosis.

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Section: Introductionmentioning

confidence: 99%

AGE-RAGE interaction in the TGFβ2-mediated epithelial to mesenchymal transition of human lens epithelial cells

Raghavan

Nagaraj

2016

Glycoconj J

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“…Even though this procedure is easy and effective in majority of the cases, there are some disadvantages to it. The Nd:YAG capsulotomy is associated with a number of complications, such as retinal detachment, IOL damage and subluxation, corneal edema, elevation of intraocular pressure, and cystoid macular edema 4–7. While some of these complications are mild and transient, other may cause permanent visual impairment.…”

Section: Introductionmentioning

confidence: 99%

A new endocapsular open ring for prevention of anterior and posterior capsule opacification

Pallikaris¹,

Stojanovic²,

Ginis³

2016

OPTH

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PurposeThe aim of this study is to demonstrate the functionality of a new design of a thick endocapsular open ring for prevention of anterior capsule opacification (ACO) and posterior capsule opacification (PCO).SettingThe Institute of Vision and Optics, University of Crete and University Hospital of Heraklion, Crete, Greece.DesignProspective, interventional pilot study.MethodsFifteen patients (17 eyes) underwent cataract surgery with phacoemulsification. During surgery, a thick endocapsular open ring (peripheral capsule reconstructor) was inserted into the capsular bag, prior to intraocular lens (IOL) implantation. Six different models of IOL were implanted. Postoperatively, the degree of ACO and PCO was evaluated and described as none, mild, moderate, or severe.ResultsThe mean follow-up period was 30±8.06 months (range: 12–36 months). At the last follow-up, mild PCO was observed in only three eyes and mild ACO in three patients. The centration of IOLs was good in all but one eye, which had a tilted IOL.ConclusionThe results of this pilot study suggest that the implantation of a new design of thick endocapsular open ring is feasible and may contribute to the prevention of PCO and ACO after cataract surgery.

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“…The problems caused by PCO can usually be remedied by laser surgery, using Nd:YAG capsulotomy to create an opening in the posterior lens capsule. However, this procedure is associated with complications such as damage to intraocular lenses (IOLs), [19,29] postoperative intraocular pressure (IOP) increases [2,9], cystoid macular oedema (CMO) [2], disruption of the anterior vitreous surface [15,23] and increased incidence of retinal detachment [20,22], and must be approached with some caution. In the USA, Nd:YAG capsulotomy is estimated to cost the Medicare programme $250 million per annum [25].…”

Section: Introductionmentioning

confidence: 99%