Neodymium‐Based Stoichiometric Ultrasmall Nanoparticles for Multifunctional Deep‐Tissue Photothermal Therapy

Rosal, Blanca del; Pérez‐Delgado, Alberto; Carrasco, Elisa; Jovanović, Dragana J.; Dramićanin, Miroslav D.; Dražić, Goran; Fuente, Ángeles Juarranz de la; Sanz-Rodrı́guez, Francisco; Jaque, Daniel

doi:10.1002/adom.201500726

Cited by 74 publications

(36 citation statements)

References 45 publications

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“…The photothermal effect was attributed to the strong absorption of Nd 3+ ions. Similar photothermal effects were also found in other Nd 3+ doped/based nanoparticles …”

Section: Applicationssupporting

confidence: 83%

Emerging ≈800 nm Excited Lanthanide‐Doped Upconversion Nanoparticles

Xie

Zhang

et al. 2016

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Lanthanide-doped upconversion nanoparticles can tune near-infrared light to visible or even ultra-violet light in emissions. Due to their unique photophysical and photochemical properties, as well as their promising bioapplications, there has been a great deal of enthusiastic research performed to study the properties of lanthanide-doped upconversion nanoparticles in the past few years. Despite the considerable progress in this area, numerous challenges associated with the nanoparticles, such as a low upconversion efficiency, limited host materials, and a confined excitation wavelength, still remain, thus hindering further development with respect to their applications and in fundamental science. Recently, innovative strategies that utilize alternative sensitizers have been designed in order to engineer the excitation wavelengths of upconversion nanoparticles. Here, focusing on the excitation wavelength at ≈800 nm, recent advances in the design, property tuning, and applications of ≈800 nm excited upconversion nanoparticles are summarized. Benefiting from the unique features of ≈800 nm light, including deep tissue penetration depth and low photothermal effect, the ≈800 nm excited upconversion nanoparticles exhibit superior potential for biosensing, bioimaging, drug delivery, therapy, and three dimensional displays. The critical aspects of such emerging nanoparticles with regards to meeting the ever-changing needs of future development are also discussed.

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“…The photothermal effect was attributed to the strong absorption of Nd 3+ ions. Similar photothermal effects were also found in other Nd 3+ doped/based nanoparticles …”

Section: Applicationssupporting

confidence: 83%

Emerging ≈800 nm Excited Lanthanide‐Doped Upconversion Nanoparticles

Xie

Zhang

et al. 2016

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“…Notably, metallic NPs can transport a therapeutic dose of heat under low exposures of extracorporeally applied light in the near‐infrared (NIR) spectrum. This may be applicable to photothermal therapy‐based cancer treatment . Therefore, a question arises: can a similar mechanism increase the photothermal heating efficiency of PCMs?…”

Section: Introductionmentioning

confidence: 99%

Low‐Power Phase Transition of Chalcogenide Glass Using Au Nanoparticle Plasmon Resonance

Cao

Liu

et al. 2020

Advanced Optical Materials

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Chalcogenide materials are attractive for all‐photonic phase‐change memories owing to their large optical contrast between amorphous and crystalline structural phases. However, high‐power heating pulses are required to switch these structural phases, which can limit the cyclability. To reduce power, Au nanoparticles (NPs) are embedded in a typical chalcogenide phase‐change material, Ge2Sb2Te5 (GST). Raman analysis shows that a GST film crystallizes at a low optical power of 2 mW, which is almost 10 times lower than that of materials not embedded with NPs. This lower power is owing to the enhanced light absorptance through the strongly localized surface plasmon resonance (LSPR) of the Au NPs. The Au NPs embedded in the GST film scatter light at λ = 587 nm, which is close to Au NP's LSPR of ≈535 nm. Laser light at 532 nm is used to measure Raman scattering from the Au–GST system. The Raman scattering is enhanced by a factor 12 compared with a bare GST film. This study indicates that the GST film–Au NP system is suitable for high‐speed, low‐power, phase‐change memory and for a new type of tunable surface‐enhanced Raman scattering substrate.

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“…Very recently, B. del Rosal et al have demonstrated the promising potentiality of ultrasmall stoichiometric (100% mol. Nd) NdVO 4 (2.4 nm) NPs for highly efficient deep-tissue photothermal therapy [80]. This potentiality can be explained taking into account the large absorption cross section at 808 nm in NdVO 4 , the high Nd content and the ultrasmall size that leads to large non-radiative rates by exploiting the energy migration to surface killer mechanism described in Fig.…”

Section: Nd 3þ As Heating Ionmentioning

confidence: 99%