Nd 3+ ions in nanomedicine: Perspectives and applications

Rosal, Blanca del; Rocha, Uéslen; Ximendes, Erving; Rodriguez, Emma Martín; Jaque, Daniel; Solé, J. Garcı́a

doi:10.1016/j.optmat.2016.06.004

Cited by 66 publications

(31 citation statements)

References 84 publications

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“…7),8) Relatively few fluorescence probes emit light in the NIR-II window, and include single-walled carbon nano-tubes, 9) cadmium-based quantum dots, 10) and large aromatic organic probes. 11) Consequently, an intense effort is underway to develop new nontoxic and biocompatible NIR-II probes for in vivo imaging. 12) Nd 3+ ions are well-suited for NIR-II optical imaging owing to their strong emission bands centered at 900 nm, 1060 and 1340 nm that correspond to transitions from the excited state 4 F 3/2 to different 4 I J states (J = 9/2, 11/2, 13/2).…”

mentioning

confidence: 99%

Near-infrared luminescence from double-perovskite Sr3Sn2O7:Nd3+: A new class of probe for in vivo imaging in the second optical window of biological tissue

Kamimura

Yamada

et al. 2017

J. Ceram. Soc. Japan

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Inorganic phosphors that emit near-infrared (NIR) light are highly valued as fluorescent probes for in vivo imaging of biological tissue. NIR-imaging, however, is limited by the paucity of probes that emit over the NIR-II window (10001400 nm). We are interested in exploring the potential of double-layered perovskite structures harboring lanthanide ions as NIR-II fluorescent probes. In this report, we describe the synthesis, and characterization of the photoluminescence, afterglow and thermoluminescence of Nd 3+-doped Sr 3 Sn 2 O 7 together with an analysis of its structural properties. Sr 3 Sn 2 O 7 :Nd 3+ has a double-layered perovskite structure with oxygen octahedral tilt and rotation, which leads to an intense NIR-II luminescence from 4f4f transition in Nd 3+ ions; the intensity of NIR-II photoluminescence of Sr 3 Sn 2 O 7 :Nd 3+ is 10 2 times higher than that of an ordinary perovskite structure, namely SrSnO 3 :Nd 3+. Moreover, we show the intra-layer planar defect in Sr 3 Sn 2 O 7 :Nd 3+ contributes to the long-lived NIR-II afterglow. Finally, we show time-resolved imaging of the long-lived NIR-II fluorescence of Sr 3 Sn 2 O 7 :Nd 3+ generate highcontrast images of probes embedded within a model tissue.

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confidence: 99%

Near-infrared luminescence from double-perovskite Sr3Sn2O7:Nd3+: A new class of probe for in vivo imaging in the second optical window of biological tissue

Kamimura

Yamada

et al. 2017

J. Ceram. Soc. Japan

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“…and 695 nm ( 5 D 0 → 7 F 4 transitions). Nd is a typical NIR emitter for subtissue imaging, when excited by 730 nm the NdL 3 @BPQDs emit at 903 nm ( 4 F 3/2 → 4 I 9/2 transitions) and 1061 nm ( 4 F 3/2 → 4 I 11/2 transitions). Because the coordination between lanthanide and BP is attributed to the orbit hybrid of Ln 5d and P 2p, luminescence of LnL 3 @BP induced by the 4f transition of Ln does not change the original characteristics of the corresponding lanthanide ions (Figure S9, Supporting Information).…”

Section: Methodsmentioning

confidence: 99%

Lanthanide‐Coordinated Black Phosphorus

Wang

et al. 2018

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Black phosphorus (BP) possesses unique physical properties and, owing to its intrinsic instability, the proper surface and chemical coordination is the key point in many applications. Herein, a facile and efficient surface lanthanide-coordination strategy based on lanthanide (Ln) sulfonate complexes is designed to passivate and functionalize different BP-based nanostructures including quantum dots, nanosheets, and microflakes. By means of Ln-P coordination, the lone-pair electrons of phosphorus are occupied, thus preventing oxidation of BP, and the LnL @BP exhibits excellent stability in both air and water. Furthermore, accompanied by the original photothermal performance of BP nanostructures, the Gd-coordinated BP has high R relativities in magnetic resonance (MR) imaging, and other Ln (Tb, Eu, and Nd) coordinated BP structures exhibit fluorescence spanning the visible to near-infrared regions. Not only is LnL surface passivation an efficient method to enhance the stability of BP, but also the MR or fluorescence derived from lanthanide ions extends the application of BP to optoelectronics and biomedical engineering.

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“…Neodymium‐doped (Nd 3+ ) FAp (Nd:FAp) was first examined in the 1960s, when Czochralski grown Nd:FAp rods were investigated regarding their lasing properties induced by the efficient 1.06 μm laser transition of Nd 3+ ions . Nowadays, Nd 3+ ‐doping of diverse nanoparticle (NP) host materials is used to exploit the unique photoluminescence (PL) properties of Nd 3+ for biomedical imaging . The PL excitation and emission of Nd 3+ ‐doped NPs is achieved in the first and second biological window (I‐BW 650‐950 nm, II‐BW 1000‐1350 nm), a favorable spectral region for in vivo imaging, in which the irradiation penetrates through biological tissue .…”

Section: Introductionmentioning

confidence: 99%

“…Nowadays, Nd 3+ ‐doping of diverse nanoparticle (NP) host materials is used to exploit the unique photoluminescence (PL) properties of Nd 3+ for biomedical imaging . The PL excitation and emission of Nd 3+ ‐doped NPs is achieved in the first and second biological window (I‐BW 650‐950 nm, II‐BW 1000‐1350 nm), a favorable spectral region for in vivo imaging, in which the irradiation penetrates through biological tissue . Besides the optical properties, also the magnetic properties of FAp can be tailored at will.…”

Section: Introductionmentioning

confidence: 99%

Paramagnetic, NIR‐luminescent Nd³⁺‐ and Gd³⁺‐doped fluorapatite as contrast agent for multimodal biomedical imaging

et al. 2018

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Combining near infrared (NIR) luminescence and magnetic resonance (MR) contrasts in a crystal host is highly desirable for contrast agents in biomedical imaging technology, as it will enable multimodal imaging processes. In the present work, biocompatible luminescent and paramagnetic fluorapatite (FAp) nanoparticles were prepared via doping with neodymium (Nd3+) and gadolinium (Gd3+), respectively. While Nd3+‐doped FAp (Nd:FAp) exhibits dopant concentration‐dependent photoluminescence (PL) in the NIR spectral region, Gd3+‐doped FAp (Gd:FAp) shows paramagnetic behavior and strong transverse relaxation effects resulting in MR contrastive properties. Remarkably, multimodal co‐doped FAp (Nd:Gd:FAp) nanoparticles combine both properties in 1 single crystal enabling luminescence as well as MR contrast.

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Nd 3+ ions in nanomedicine: Perspectives and applications

Cited by 66 publications

References 84 publications

Near-infrared luminescence from double-perovskite Sr<sub>3</sub>Sn<sub>2</sub>O<sub>7</sub>:Nd<sup>3+</sup>: A new class of probe for in vivo imaging in the second optical window of biological tissue

Near-infrared luminescence from double-perovskite Sr<sub>3</sub>Sn<sub>2</sub>O<sub>7</sub>:Nd<sup>3+</sup>: A new class of probe for in vivo imaging in the second optical window of biological tissue

Lanthanide‐Coordinated Black Phosphorus

Paramagnetic, NIR‐luminescent Nd³⁺‐ and Gd³⁺‐doped fluorapatite as contrast agent for multimodal biomedical imaging

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Nd 3+ ions in nanomedicine: Perspectives and applications

Cited by 66 publications

References 84 publications

Near-infrared luminescence from double-perovskite Sr<sub>3</sub>Sn<sub>2</sub>O<sub>7</sub>:Nd<sup>3+</sup>: A new class of probe for in vivo imaging in the second optical window of biological tissue

Near-infrared luminescence from double-perovskite Sr<sub>3</sub>Sn<sub>2</sub>O<sub>7</sub>:Nd<sup>3+</sup>: A new class of probe for in vivo imaging in the second optical window of biological tissue

Lanthanide‐Coordinated Black Phosphorus

Paramagnetic, NIR‐luminescent Nd3+‐ and Gd3+‐doped fluorapatite as contrast agent for multimodal biomedical imaging

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Paramagnetic, NIR‐luminescent Nd³⁺‐ and Gd³⁺‐doped fluorapatite as contrast agent for multimodal biomedical imaging