Neoadjuvant therapy

Wang, Peng-Hui; Yang, Szu‐Ting; Liu, Chia-Hao

doi:10.1097/jcma.0000000000000855

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…MIBC is typically treated with RC following neoadjuvant chemotherapy (NAC), which has been shown to improve survival rates by reducing the chances of local recurrence and distant metastasis [ 24 , 25 ]. Neoadjuvant therapy is conducted before surgery to reduce the size of the tumor and lower the pathological stage, so as to extend patient survival and increase the success rate of radical resection [ 26 , 27 ]. However, about 50% of MIBC patients cannot tolerate chemotherapy due to adverse effects of the drugs and/or non-responsiveness [ 28 ].…”

Section: Current Status Of Immunotherapy For Bladder Cancermentioning

confidence: 99%

Bladder Cancer: Immunotherapy and Pelvic Lymph Node Dissection

Fan,

Deng,

Wang

et al. 2024

Vaccines

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Bladder cancer, a common malignancy of the urinary system, is routinely treated with radiation, chemotherapy, and surgical excision. However, these strategies have inherent limitations and may also result in various side effects. Immunotherapy has garnered considerable attention in recent years as a novel therapeutic approach. It harnesses and activates the patient’s immune system to recognize and eliminate cancer cells, which not only prolongs therapeutic efficacy but also minimizes the toxic side effects. Several immune checkpoint inhibitors and cancer vaccines have been developed for the treatment of bladder cancer. Whereas blocking immune checkpoints on the surface of tumor cells augments the effect of immune cells, immunization with tumor-specific antigens can elicit the production of anti-tumor immune effector cells. However, there are several challenges in applying immunotherapy against bladder cancer. For instance, the efficacy of immunotherapy varies considerably across individual patients, and only a small percentage of cancer patients are responsive. Therefore, it is crucial to identify biomarkers that can predict the efficacy of immunotherapy. Pelvic lymph nodes are routinely dissected from bladder cancer patients during surgical intervention in order to remove any metastatic tumor cells. However, some studies indicate that pelvic lymph node dissection may reduce the efficacy of immunotherapy by damaging the immune cells. Therefore, the decision to undertake pelvic lymph node removal should be incumbent on the clinical characteristics of individual patients. Thus, although immunotherapy has the advantages of lower toxic side effects and long-lasting efficacy, its application in bladder cancer still faces challenges, such as the lack of predictive biomarkers and the effects of pelvic lymph node dissection. Further research is needed to explore these issues in order to improve the efficacy of immunotherapy for bladder cancer.

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Section: Current Status Of Immunotherapy For Bladder Cancermentioning

confidence: 99%

Bladder Cancer: Immunotherapy and Pelvic Lymph Node Dissection

Fan,

Deng,

Wang

et al. 2024

Vaccines

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“…Como delineado na Apesar de o modelo ter exibido competência satisfatória em tarefas de múltipla escolha e raciocínio lógico, não obteve sucesso no exame, apontando a necessidade urgente de otimizações e treinamento suplementar. As taxas de precisão foram notavelmente superiores nas perguntas em inglês, destacando a importância do idioma na compreensão e resolução das questões (Wang, et al, 2023).…”

Section: Performance Ofunclassified

Aplicações E Implicações Da Inteligência Artificial Na Otimização De Farmacoterapias E Processos Farmacêuticos

Soares,

Santos,

Pontes Neto

2024

Rev. Contemp.

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Este estudo tem como objetivo é salientar a crescente importância da inteligência artificial (IA) no âmbito farmacêutico e de saúde, destacando sua capacidade de impulsionar transformações significativas em diversas esferas, abrangendo desde a pesquisa e fabricação de medicamentos até o diagnóstico e o envolvimento com os pacientes. Ademais, pretende-se explorar as considerações éticas e os obstáculos relacionados à integração da IA na indústria farmacêutica, enquanto ressalta os benefícios em potencial dessa tecnologia, como a melhoria dos procedimentos e a adaptação da terapia medicamentosa. Além disso, a IA tem sido aplicada no varejo farmacêutico para otimizar a gestão de inventário e antecipar as necessidades dos pacientes. No entanto, sua implementação enfrenta desafios, como a falta de estudos abrangentes sobre sua eficácia e a dificuldade de acesso a algoritmos atualizados. Esta pesquisa revisa a literatura sobre o emprego da inteligência artificial em farmacoterapias e processos farmacêuticos nos últimos cinco anos. Utilizando abordagem qualitativa, foram pesquisados artigos nas plataformas PubMed e BVS, com descritores específicos como Artificial Intelligence, Pharmaceutical, Chatbot in Pharmacy e Hospital Pharmacy. Após a exclusão de artigos fora do escopo temático, foram selecionadas 10 publicações relevantes.

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“…Recently, due to significantly improved technology with a better understanding of tumorigenesis and the continuous innovation of targeted therapy and chemotherapy regimens, the multidisciplinary decision-making and multimodality approach has directed patient-tailored therapy. [6][7][8] Therefore, any new identified biomarker may be at a highest chance for developing a brand-new and precisely targeted agent and offering the best benefit-risk ratio between the therapeutic efficacy and therapyrelated toxicity. 9,10 We applause the great work of the authors; however, our concern is still looking forward to seeing the kind response by authors.…”

Section: Dear Editormentioning

confidence: 99%

The statistical significance may be mis-interpretated

Chang

2023

Journal of the Chinese Medical Association

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Neoadjuvant therapy

Cited by 6 publications

References 20 publications

Bladder Cancer: Immunotherapy and Pelvic Lymph Node Dissection

Bladder Cancer: Immunotherapy and Pelvic Lymph Node Dissection

Aplicações E Implicações Da Inteligência Artificial Na Otimização De Farmacoterapias E Processos Farmacêuticos

The statistical significance may be mis-interpretated

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