Neoadjuvant Intracarotid Chemotherapy for Treatment of Advanced Adenocystic Carcinoma of the Lacrimal Gland

Adenoid Cystic Carcinoma of the Cavernous Region-Case Report-

“…1,[3][4][5][6] Perineural invasion was found in 52.6% of primary resection specimens with local invasion, perineural extension, and a tendency toward local recurrence and distant metastasis. 1,6) The present case showed similar characteristics.…”

“…1,3,5,7) However, total resection is almost impossible because of the invasive character, 5) and most ACCs (42%) recur within the first 3 years. [3][4][5] Radiation therapy is effective and has been used successfully to reduce the tumor mass. 3,5,7) Even if local control is achieved, distant metastasis 1,7) occurs in as many as 39% of cases, 5) most often in the liver, bone, and lung.…”

“…3,5,7) Even if local control is achieved, distant metastasis 1,7) occurs in as many as 39% of cases, 5) most often in the liver, bone, and lung. 2,4) The prognosis remains poor, with a survival of less than 50% at 5 years and 20% at 10 years. 4) Therefore, resection of ACC should be as complete as possible.…”

“…2,4) The prognosis remains poor, with a survival of less than 50% at 5 years and 20% at 10 years. 4) Therefore, resection of ACC should be as complete as possible.…”

“…1,6) Most ACCs arise in the major and minor salivary glands, nasopharynx, and lacrimal glands, but also arise from the upper respiratory tract, the lungs, the mammary gland, the skin, the mastoid air cell, and the genital tract. [1][2][3][5][6][7] ACCs account for 11% 5) or 25-30% 4) of epithelial neoplasms in the lacrimal gland. The incidence of intracranial invasion varies from 4% [1][2][3]5,6) to 22%.…”