Neoadjuvant chemotherapy with cisplatin and 5-fluorouracil in advanced squamous cell carcinoma of the head and neck: a randomized Phase III study

Lewin, Freddi; Damber, Lena; Jonsson, Håkan; Andersson, Tobias; Berthelsen, A; Biörklund, Anders; Blomqvist, Erik; Evensen, Jan F.; Hansen, Hanne Sand; Hansen, Olfred; Jetlund, Olav; Mercke, Claes; Modig, Hans; Overgaard, Marie; Rosengren, Bengt; Tausjø, Johan; Ringborg, Ulrik

doi:10.1016/s0167-8140(97)01922-1

Cited by 51 publications

(32 citation statements)

References 16 publications

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“…Five trials concerning radiotherapy with/without neoadjuvant chemotherapy were included in this report (2,5,7,8,10). All of them were included in the meta-analysis (1).…”

Section: All Sites Except Nasopharynxmentioning

confidence: 99%

A Systematic Overview of Radiation Therapy Effects in Head and Neck Cancer

et al. 2003

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“…Five trials concerning radiotherapy with/without neoadjuvant chemotherapy were included in this report (2,5,7,8,10). All of them were included in the meta-analysis (1).…”

Section: All Sites Except Nasopharynxmentioning

confidence: 99%

A Systematic Overview of Radiation Therapy Effects in Head and Neck Cancer

et al. 2003

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“…Radiotherapy alone, or combined with neo-adjuvant chemotherapy, was for several years the preferred treatment in advanced disease, especially for the group 65 years [4]. There was no difference in peri-and postoperative deaths or in serious complications between the two age-groups.…”

Section: Resultsmentioning

confidence: 92%

“…The neck has, as a rule, been treated together with the primary tumour. Neo-adjuvant chemotherapy with cisplatin and 5-fluorouracil, according to a Nordic protocol [4] was administered to 53 patients. Tumours of advanced stage were otherwise treated by radiotherapy alone.…”

Section: Methodsmentioning

confidence: 99%

Squamous Cell Carcinoma of the Head and Neck in the Elderly

Boysen¹

2009

TOOTORJ

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Abstract:Background: Increasing life expectancy and incidence of head and neck carcinomas, including some types of head and neck malignancies, lead to a constantly higher proportion of old oncologic patients. Previous reports regarding the outcome for elderly patients with head and neck carcinomas squamous cell carcinoma (HNSCC) are controversial. For further insight, a large single-institution material has been analysed.Material: Prospective recording of demographic details, continuous follow-up and determining exact cause of deaths of patients with carcinoma of the head and neck have been in progress over a period of 14 years. Having excluded 154 patients (7.3%), who did not follow-up, who had distant metastases at diagnosis, or who had received extensive treatment for a previous head and neck carcinoma or who refused treatment, or for medical or mental reasons, were unable to receive curative treatments. The material includes 1944 patients, of whom 37% received combined treatment, 58% radiotherapy alone and 6% surgery alone. The mean age was 65 years with a mean follow-up of 3.8 years. The material was divided into two groups; 65 and >65 years of age and analysed by means of X 2 tests and log-rank X 2 tests.Results: Early stage primary tumours and a more advantageous N-classification were more conspicuous among the older patients (p = 0.2406 and p<0.0002). The group of patients 65 years had a significantly better disease-specific survival rate compared to the older patients (p = 0.145). However, 40 % of the older patients were alive with no evidence of disease. By comparing 65-74 patients with patients' 76 years of age, a p-value of 0.0105 was obtained in favour of the younger group, but still an appreciable number of the older patients escaped their HNSCC. Conclusion:Given a satisfactory mental and physical condition, patients older than 65 years had a reasonable diseasespecific survival. It is therefore no reason to withhold appropriate treatment for the elderly, fit patients which could prevent or delay the misery and devastating situation, as well as a reduction in the heavy expenditures that patients with persistent or recurrent head and neck tumours represent.

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“…Induction chemotherapy has been evaluated in numerous studies, including several prospective randomized trials [11][12][13][14][15]. No clear survival benefit has ever been demonstrated.…”

Section: Discussionmentioning

confidence: 99%

“…However, these studies usually included a variety of primary sites, including oral cavity, oropharynx, hypopharynx, and larynx [12,14,15]. Tumors arising from these sites have different natural histories and different responses to therapy and should probably be evaluated separately.…”

Section: Discussionmentioning

confidence: 99%