A Systematic Overview of Radiation Therapy Effects in Head and Neck Cancer

Zackrisson, Björn; Mercke, Claes; Strander, Hans; Wennerberg, Johan; Cavallin‐Ståhl, Eva

doi:10.1080/02841860310014886

Cited by 113 publications

(70 citation statements)

References 46 publications

(38 reference statements)

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“…Various radiosensitizers have been developed in the past, which were designed to sensitize hypoxic tumor cells to radiation. However, their clinical use was hampered because of their neurotoxicity and low efficacy (Rowinsky, 1999;Zackrisson et al, 2003;Overgaard et al, 2005;Rischin et al, 2005). Recently, Sobhanifar et al (2005) examined human tumor biopsies and human cancer xenografts with expression of HIF-1a and distribution of a chemical hypoxia marker, pimonidazole, which become reactive at less than 10 mm Hg oxygen tension.…”

Section: Discussionmentioning

confidence: 99%

Significance of HIF-1-active cells in angiogenesis and radioresistance

et al. 2007

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Human solid tumors contain hypoxic regions that have considerably lower oxygen tension than the normal tissues. Hypoxia offers resistance to radiotherapy and anticancer chemotherapy, as well as predispose to increased tumor metastases. Furthermore, hypoxia induces hypoxia-inducible factor-1 (HIF-1), which in turn increases tumor angiogenesis. Thus, eradication of HIF-1-active/hypoxic tumor cells is very important for cancer therapy. We have previously reported that procaspase-3 fused with a von Hippel-Lindau (VHL)-mediated protein destruction motif of alpha subunit of HIF-1 (HIF-1a) containing Pro564, named TAT-ODDprocaspase-3 (TOP3), specifically induced cell death to hypoxic cells in vivo as well as in vitro. We now report that TOP3 also eradicates the radiation-induced HIF-1-active tumor cells. HIF-1 activity in the xenografts of human tumor cells, which express luciferase under the transcriptional control of HIF-1, were monitored and quantified daily with an in vivo bioluminescence photon-counting device. HIF-1 activity in tumors was more rapidly increased by ionizing radiation (IR) compared to untreated tumors. TOP3 efficiently decreased the HIF-1-activity in irradiated tumors as well as unirradiated ones, indicating TOP3 eradicated tumor cells with HIF-1-activity induced by IR as well as hypoxia. Eradication of HIF-1-active/hypoxic cells in the xenografts during irradiation exhibited significant suppression in angiogenesis and strong enhancement in a long-term growth suppression of tumor xenografts. These results further strengthen the argument that HIF-1-active/ hypoxic cells play crucial roles in angiogenesis and radioresistance.

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Section: Discussionmentioning

confidence: 99%

Significance of HIF-1-active cells in angiogenesis and radioresistance

et al. 2007

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“…Radiotherapy of the head and neck region may cause patients irreversible and distressing side effects (28). More conformal dose distributions than in 3-D CRT can reduce the risk of xerostomia (6).…”

Section: Discussionmentioning

confidence: 99%

Can Photon IMRT be improved by combination with mixed electron and photon techniques?

Mu¹,

Olofsson²,

Karlsson³

et al. 2004

Acta Oncologica

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“…One explanation could be the positive effect of accelerated RT. Randomized trials on mostly intermediate-stage and advanced head-and-neck cancer, not focusing on laryngeal cancer exclusively, have shown that hyperfractionation and acceleration can improve the results of RT [15,16]. In the CHART trial for head and neck cancers there was no significant improvement in LRC with CHART, possibly because of the lower total doses.…”

Section: Discussionmentioning

confidence: 89%