“…Nevertheless, the 2-year and 5-year DFS rates remain modest at approximately 40%–50% and 30%–40%, respectively ( Supplementary Table S1 ). 12 , 13 , 14 , 15 Within the cohort subjected to chemotherapy, only 30%–40% achieved complete resection, with a major pathological response (MPR) of 7%–20% and a complete pathological response (pCR) of 2.2% at the time of surgery. 12 , 16 Notably, recent research involving the combination of neoadjuvant chemotherapy with PD-1 and PD-L1 inhibitors for resectable stage III NSCLC reported an 80% downstaging rate and 78%–89% complete resection rate.…”