Neoadjuvant chemotherapy followed by post-partum chemoradiotherapy and chemoconsolidation for stage IIIB glassy cell cervical carcinoma during pregnancy

Platinum Derivatives During Pregnancy in Cervical Cancer

“…In 78.6% of women in the case group (33/42), a diagnosis of squamous cell carcinoma was established, [11][12][13][14][15][16][17]19,[21][22][23][24][25][26][27]29,31,34 whereas in 14.3% of women in the case group (6/42), adenocarcinoma was diagnosed 11,14,15,18,19,34 ; additionally, one woman each in the case groups of clear cell, of small cell, and of glossy cell carcinoma was identified. 17,20,30 The stage at diagnosis during pregnancy was early (stages I and II) in 93.5% of women in the case group and advanced in 6.5% of women in the case group. The mean gestational age at cervical cancer diagnosis was 19.5 weeks (SD 4.7, median 20 weeks, range 8-29 weeks), whereas the mean gestational age at chemotherapy administration was 23.9 weeks (SD 4.2, median 24 weeks, range 17-33 weeks).…”

“…The administration of platinum derivatives resulted in 97.9% of women in the case group (47/48) in the birth of live neonates [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][32][33][34] and in 2.1% of women in the case group (1/48) in miscarriage. 31 In relation to cisplatin, 47 pregnancies (47 newborns) were identified ; regarding carboplatin administration, only one pregnancy (one newborn) was retrieved.…”

“…31 In relation to cisplatin, 47 pregnancies (47 newborns) were identified ; regarding carboplatin administration, only one pregnancy (one newborn) was retrieved. 17 Specifically, cisplatin was administered either as monotherapy 11,[14][15][16][18][19][20][21][22]24,25,27,[31][32][33][34] or combined with bleomycin, 26 5-fluorouracil, 33 paclitaxel, 11,12,17 vincristine, 11,13,23,[29][30][31][32] or vincristine and bleomycin 28 ; carboplatin was given in combination with paclitaxel. 17 The mean age of patients with cervical cancer at diagnosis was 32.5 years (standard deviation [SD] 4.3, median 32.5 years, range 25-42 years).…”

Glassy Cell Carcinoma of the Cervix and Metastasis in Episiotomy Scar

“…20,21 Some authors have made an association between this tumor and pregnancy; however, others did not find any association between them. 20,21 Some authors have made an association between this tumor and pregnancy; however, others did not find any association between them.…”

“…20,21 Some authors have made an association between this tumor and pregnancy; however, others did not find any association between them. 20 The prognosis of patients with glassy cell carcinoma is considered to be poor because of its rapid progression, its frequent distant metastasis, and its relative resistance to conventional treatment modalities (surgery, radiotherapy, and chemotherapy). 20 The prognosis of patients with glassy cell carcinoma is considered to be poor because of its rapid progression, its frequent distant metastasis, and its relative resistance to conventional treatment modalities (surgery, radiotherapy, and chemotherapy).…”