Neoadjuvant bleomycin, etoposide, and cisplatin in adult neuroblastoma arising from the broad ligament of the uterus

Milam, Michael R.; Gabel, Stephanie; Milam, R. Ashley; Liu, Jinsong; Ramírez, Pedro T.

doi:10.1016/j.ygyno.2007.06.027

Cited by 3 publications

(4 citation statements)

References 9 publications

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“…[16] Adult regimens have been similar with additional reported success with agents include topotecan, bleomycin, and ifosfamide. [17][18][19][20][21][22] Although adults are reported to have significantly worse survival rates than children, this may be related to a more advanced stage of disease at diagnosis. When matched for stage and other prognostic factors, recent reports suggest the prognosis for adult and pediatric patients may be similar.…”

Section: Discussionmentioning

confidence: 99%

Ganglioneuroblastoma in an adult patient

Monsma

Wright

Chung

2015

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Neuroblastoma (NB) is a common tumor in children but is extremely rare in adults. Sparse literature exists on adult NB or the subtype ganglioneuroblastoma (GNB). We present a 40-year-old male complaining of decreased strength and pain in his left hand. Imaging studies showed a paraspinal tumor at T1 and an abdominal mass while laboratory tests were significant for high plasma and urine metanephrines suggesting a diagnosis of pheochromocytoma. Percutaneous core needle biopsy was performed and a diagnosis of GNB was made based on immunohistochemical staining. The patient underwent debulking surgery and final pathology confirmed the diagnosis. The patient demonstrates no signs of local recurrence but developed diffuse bony metastasis after the debulking procedure. Systemic therapy regimens for GNB are largely extrapolated from pediatric regimens and efficacy is unknown. Differentiation between adult and pediatric NB remains unclear.

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Section: Discussionmentioning

confidence: 99%

Ganglioneuroblastoma in an adult patient

Monsma

Wright

Chung

2015

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“…Etoposide binds to a complex of DNA and topoisomerase II, which is cytotoxic. Teniposide functions similarly to etoposide Bleomycin was used in conjunction with etoposide and cisplatin in the treatment of adult neuroblastoma arising from the broad ligament of the uterus (Milam et al, 2007). The patient died 20 months after diagnosis (Milam et al, 2007).…”

Section: Iobenguanementioning

confidence: 99%

“…Teniposide functions similarly to etoposide Bleomycin was used in conjunction with etoposide and cisplatin in the treatment of adult neuroblastoma arising from the broad ligament of the uterus (Milam et al, 2007). The patient died 20 months after diagnosis (Milam et al, 2007). Cisplatin, vinblastine, and bleomycin (CVB) have been used in the treatment of relapsed, disseminated neuroblastoma (Bostrom et al, 1984).…”

Section: Iobenguanementioning

confidence: 99%

The Cell Biology of Neuroblastoma

Denny¹

2012

Neuroblastoma - Present and Future

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“…It most frequently originates in one of the adrenal glands but can also develop in the abdomen or pelvis. As far as we are aware, there have been only three cases of neuroblastoma arising from genital reproductive organs; the sites of which were the broad ligament of the uterus, uterine cervix, and ovaries . There are no reports of cases in which neuroblastoma developed in the uterine corpus.…”

Section: Introductionmentioning

confidence: 99%

Central type primitive neuroectodermal tumor/neuroblastoma of the uterus: A case report

Shimada

Todo

Okamoto

et al. 2014

J of Obstet and Gynaecol

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We encountered a 63-year-old woman who had a uterine tumor with peritoneal dissemination and para-aortic lymph node metastasis. Microscopic specimens of the tumor showed a small blue round-cell tumor. Immunohistochemistry showed cells to be negative for cytokeratin AE1/3, desmin, myogenin, CD10, CD34, and CD99, focal positive for vimentin, and positive for muscle-specific actin (HHF-35), neurofilament, synaptophysin and CD56. Fluorescence in situ hybridization revealed no split signal showing Ewing sarcoma breakpoint region 1 gene translocation. Deletion of 1p36 was identified in 30% of the tumor cells. These findings are thought to be equivalent to central type primitive neuroectodermal tumors/neuroblastoma. Cytoreductive debulking surgery followed by chemotherapy, including cyclophosphamide, vincristine and adriamycin, resulted in complete remission. She has no evidence of disease at 24 months after surgery.

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Neoadjuvant bleomycin, etoposide, and cisplatin in adult neuroblastoma arising from the broad ligament of the uterus

Cited by 3 publications

References 9 publications

Ganglioneuroblastoma in an adult patient

Ganglioneuroblastoma in an adult patient

The Cell Biology of Neuroblastoma

Central type primitive neuroectodermal tumor/neuroblastoma of the uterus: A case report

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