Central type primitive neuroectodermal tumor/neuroblastoma of the uterus: A case report

Abstract

We encountered a 63-year-old woman who had a uterine tumor with peritoneal dissemination and para-aortic lymph node metastasis. Microscopic specimens of the tumor showed a small blue round-cell tumor. Immunohistochemistry showed cells to be negative for cytokeratin AE1/3, desmin, myogenin, CD10, CD34, and CD99, focal positive for vimentin, and positive for muscle-specific actin (HHF-35), neurofilament, synaptophysin and CD56. Fluorescence in situ hybridization revealed no split signal showing Ewing sarcoma breakpoint region 1 gene translocation. Deletion of 1p36 was identified in 30% of the tumor cells. These findings are thought to be equivalent to central type primitive neuroectodermal tumors/neuroblastoma. Cytoreductive debulking surgery followed by chemotherapy, including cyclophosphamide, vincristine and adriamycin, resulted in complete remission. She has no evidence of disease at 24 months after surgery.

Adjuvant chemotherapy for a primitive neuroectodermal tumor of the uterine corpus: A case report and literature review

“…Reports with incomplete information about chemotherapy were also excluded. Of a total of 178 papers identified from the search terms in the MEDLINE database, 49 cases fulfilled the mentioned criteria (Table ). We analyzed the choice of chemotherapy regimen in relation to the patients’ ages and divided patients into the following groups: adolescence (<20 years), reproductive (20–40 years), premenopausal (40–60 years) and elderly (>60 years).…”