Neoadjuvant and adjuvant alpha-blockade improves early results of high-energy transurethral microwave thermotherapy for lower urinary tract symptoms of benign prostatic hyperplasia: a randomized, prospective clinical trial

A Meta-Analysis on the Efficacy and Tolerability of α₁-Adrenoceptor Antagonists in Patients with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Obstruction

“…A major drawback was the fact that this study used the α 1 -adrenoceptor antagonist terazosin that was associated with quite some side effects. Therefore, α 1 -adrenoceptor antagonists with a more acceptable side effect profile such as alfuzosin and tamsulosin are an important improvement in the medical management of LUTS suggestive of BPO [57]. …”

Invasive and Minimally Invasive Treatment Modalities for Lower Urinary Tract Symptoms: What Are the Relevant Differences in Randomised Controlled Trials?

“…The most frequently reported complications at 1 year of follow-up were urinary tract infections (16%) and irritative voiding symptoms (29%); both complications occurred more frequently in the TUMT group than after TURP (4% and 19% respectively) [87]. Other studies reported a lower complication rate, but patient follow-up was usually shorter [31, 60, 88, 89, 90, 91]. Patients treated with high-energy TUMT need no hospitalisation, but catheterisation time is long, varying between 6 and 35 days (mean 14.5) [87].…”

Effect of Heat Exposure on Viability and Contractility of Cultured Prostatic Stromal Cells

“…Under in vivo conditions, thermotherapies might induce apoptotic rather than necrotic changes in some smooth muscle cells leading to delayed cell death. This could explain delayed improvement in lower urinary tract symptoms after microwave therapy, which is accelerated by neoadjuvant and adjuvant α–blockade [23]. Furthermore, heat application by TUMT or TUNA might provide additional specific effects as compared to heating in an incubation chamber.…”