Neo-adjuvant chemotherapy for cervical cancer in pregnancy: a case report and literature review

How much platinum passes the placental barrier? Analysis of platinum applications in 21 patients with cervical cancer during pregnancy

“…40 However, 3 patients are described in the literature as having progressive disease despite neoadjuvant chemotherapy. 2,26 Fortunately, we did not observe any progressive disease in any of our patients.…”

“…2,26 Up to the end of 2012, 24 small studies and case reports had been published on this issue, and only a few have been added in subsequent months. 27,28 According to international recommendations, the prognosis in women with early cervical cancer does not seem to be worsened by either pregnancy itself or by delay to await fetal viability.…”

“…38,39 The dosage used for nearly all patients in the present study is exactly in this range, whereas the number of applied cycles mainly depends on the time of the cancer diagnosis. 26,27,40 Because of a lack of data, it is not decided yet whether neoadjuvant monotherapy using cisplatinum or carboplatinum is inferior to any combination with paclitaxel, 5-fluorouracil, or vincristine. 2 Platinum is an effective drug in the treatment of patients diagnosed with cervical cancer.…”

Ovarian dysgerminoma in pregnancy: A case report and literature review

“…34 There are more case reports showed that no abnormalities was observed in infant after the administration of cisplatin in women with cervical cancer. [45][46][47][48] Cisplatin therapy seems the most reliable form of chemotherapy, permitting a good outcome for most patients. It is reported that paclitaxel and carboplatin were used in pregnancy after organogenesis without apparent fetal effects, though the evidence was mainly based on case reports.…”

Pregnancy-associated-cancer in the French West Indies (Martinique): maternal and neonatal outcomes

“…As yet, there not appear to be a clear move towards a policy of considering the possibility of oncological treatments during pregnancy. According to Kirby [ 14 ], “the biggest challenge is educating the public that chemotherapy is possible in pregnancy without harm for the baby.” The literature contains various reports of women who received chemotherapy during pregnancy and who went on to give birth to healthy babies without congenital malformations [ 12 , 15 , 16 ]. In our study, chemotherapy was not the first choice treatment modality for PAC.…”