Ovarian dysgerminoma in pregnancy: A case report and literature review

Chen, Yuanyuan; Luo, Ying; Han, Choong‐Hee; Tian, Wenyan; Yang, Wen; Wang, Yingmei; Xue, Fengxia

doi:10.1080/15384047.2018.1450118

Cited by 32 publications

(58 citation statements)

References 70 publications

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“…[29,30].These effects seem to be closely related to the type of drugs, dose and chemotherapy duration. [31] In our study there is no evidence on any reproductive outcome reduction following multiple chemotherapy cycles. Similar data are reported in several papers that showed that PEB versus PVC chemotherapy for MOCGTs does not appear to affect reproduction or menstrual cycle which normalized within 6 months in 90% of cases [32][33][34].Similarly, we reported that 78% of the patients had regular menstrual cycles during and after chemotherapy, on the other side 22% patients presented amenorrhea during chemotherapy but had regular cycles 5 months after treatment.…”

Section: Methodscontrasting

confidence: 62%

Germinal Ovarian Tumors In Reproductive Age Women: Fertility-Sparing And Outcome

Dellino

Silvestris

Loizzi

et al. 2020

Preprint

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Purpose MOGCTs (malignant ovarian germ cell tumours) is a rare tumour, which mainly affects patients in reproductive age. The aim of this study is evaluate the fertility and survival outcomes in young women with MOCGTs treated with fertility-sparing surgery (FFS).Methods From 2000 to 2018 twenty-eight patients with diagnosis of MOGCTs in reproductive age at the University of Bari were collected. Most received FFS and in patients treated conservatively, the reproductive outcome and survival were investigated. Data of patient demographics, clinical presentation, oncology markers dosage, staging, type of surgery histological examination, survival and reproductive outcome were collected from hospital and office charts. All informed consent was obtained from all patientsResults Twenty-eight patients with diagnosis of MOGCTs were collected. The median age was 24 (range: 9-45). The majority of the patients had stage IIIC. Twenty-four woman received fertility-sparing surgery consisting in unilateral ovariectomy and omentectomy whereas only 4 women based on their stage (IIIC) received a radical surgery (hysterectomy with bilateral adnexectomy, lymphadenectomy and omentectomy). Our study shows that FFS in MOGCTs can produce good results both on reproductive outcomes and on survival. Indeed, in our group there was only one case of exitus as result of recurrence. On the other side, patients after FFS maintained normal ovarian function and 5/5 women who have looked for pregnancy, obtained it spontaneously. The median follow-up was 90 moth (range 3-159).Conclusion Conservative surgery for MOGCTs should be considered for women in the reproductive age group who desire preservation of fertility.

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Section: Methodscontrasting

confidence: 62%

Germinal Ovarian Tumors In Reproductive Age Women: Fertility-Sparing And Outcome

Dellino

Silvestris

Loizzi

et al. 2020

Preprint

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“…OD can occur in women aged from 7 months to 70 years, [ 31 ] but predominantly in young pregnant women. [ 1 , 7 , 8 , 30 , 32 ] The majority of OD pregnant women usually have non-specific symptoms, [ 33 ] including the most common abdominal pain (35.3%), followed by abdominal distention (19.6%), a growing mass (19.6%), multiple symptoms (18.6%), and non-symptoms (21.6%). [ 2 ] In our study, abdominal pain was the main complaint of the patient and led to a cesarean section.…”

Section: Discussionmentioning

confidence: 99%

“…Malignant germ cell tumor (MGCT) is an extraordinary rare ovarian cancer, which occupies no >5% of all ovarian cancers [ 1 – 4 ] and 18% to 26% of all ovarian cancer with pregnancy. [ 5 , 6 ] MGCT mainly includes the following subtypes: ovary dysgerminoma (OD) (38.2%), yolk sac tumor (30.4%), and immature teratoma (15.7%).…”

Section: Introductionmentioning

confidence: 99%

“…[ 2 ] OD is the most common subtype of MGCT and often occurs in adolescence and early adulthood. [ 1 , 7 – 10 ] In pregnant women, OD patients only account for about 0.0002% to 0.001%, [ 11 ] and OD usually has a unilateral onset and is diagnosed at an early stage. It is difficult to achieve a large sample of OD due to its relatively low incidence.…”

Section: Introductionmentioning

confidence: 99%

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Pregnancy with giant ovarian dysgerminoma

Zhang¹,

Zhai

Huang³

et al. 2020

Medicine

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Rationale: Dysgerminoma is an extraordinarily rare neoplasm arising from the malignant germ cells of the ovary. Early antenatal diagnosis and proper management of the neoplasm to improve maternal-neonatal results are the considerable challenges facing the gyne-oncologist. We summarize the clinical features and discuss treatment strategies of the ovary dysgerminoma (OD). Besides, we also review the literature on OD in PubMed, Web of Science Core Collection, Library of Congress, and LISTA from 1939 to 2019 to evaluate its clinical characteristics, feto-maternal compromise, management, and fertility outcome. Patient concerns: A 25-year-old pregnant woman reported lower abdominal pain and vomiting. Diagnosis: The patient was diagnosed as right OD. Interventions: She received a cesarean section due to severe abdominal pain, delivered a healthy girl at 38 C 4 weeks of gestation, and accepted fertility-preserving surgery. However, the patient refused chemotherapy postoperatively. Outcomes: The patient was followed up 42 days, 3 months, and 6 months after surgery, and no tumor recurrence was observed. Lessons: OD has non-specificity characteristics, including age, symptoms, image date, and tumor marks. However, these abnormal indicators may provide some evidence for accurate antenatal diagnosis. The management strategies should be considered comprehensively on an individual basis, and fertility-preserving surgery should be carried out in the second trimester if further pregnancy is desired. Adjuvant chemotherapy needs to be applied to the treatment of OD patients with The International Federation of Gynecology and Obstetrics (FIGO) stages II, III, and IV and timely chemotherapy is suggested if there are several weeks before the expected date of delivery. The overall prognosis of OD patients is excellent.

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“…Keimzelltumoren können extrem selten auch primär extraovariell entstehen. Fälle mit mediastinaler oder retroperitonealer Primärlokalisation sind in Fallberichten beschrieben worden [8][9][10][11][12]. Findet sich ein primär extragonadales Dysgerminom in der Schwangerschaft, handelt es sich um eine absolute Rarität.…”

Section: Introductionunclassified

Management Unterbauchraumforderungen in der Schwangerschaft – Fallbeschreibung eines extraovariell-intraabdominalen Dysgerminoms mit Überblick über die Literatur

Litzka

Leebmann

Wiesinger

et al. 2020

Z Geburtshilfe Neonatol

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Zusammenfassung Einleitung Dysgerminome sind seltene maligne Keimzelltumoren des Ovars und in der Schwangerschaft eine Rarität. Neben ovariellen sind außerhalb der Schwangerschaft auch primär extraovarielle Dysgerminome des Mediastinums und Retroperitoneums beschrieben. Nach adäquater chirurgischer und systemischer Therapie besteht eine gute Prognose. Methodik Bericht eines primär extraovariell-intraabdominalen Dysgerminoms in der Schwangerschaft, systematische Literaturrecherche. Fallbericht Bei einer 35-jährigen II Gravida wird in der 20. Schwangerschaftswoche ein suspekter intraabdominaler Tumor festgestellt. Bei der folgenden Explorativlaparotomie wird bei unauffälligen Ovarien ein Tumorkonglomerat mit Darminfiltration reseziert und ein Dysgerminom diagnostiziert. In der 34. SSW wird eine primäre Sectio Caesarea durchgeführt, erneuter Tumorbefall komplett reseziert und folgend systemisch Bleomycin, Etoposid und Cisplatin appliziert. Nach 12 Monaten erfolgt bei zystischen Adnexen eine erneute Exploration mit Hysterektomie und Adnexektomie beidseits ohne Nachweis von Malignität. Nach nun 16 Monaten besteht weiter eine Komplettremission. Zusammenfassung Präsentiert wird die Erstbeschreibung eines primär extraovariell-intraabdominalen Dysgerminoms in der Schwangerschaft. Durch die Entscheidung, die zytoreduktive Operation während und die Systemtherapie erst nach Prolongation der Schwangerschaft durchzuführen, konnte größtmöglicher Benefit für das Kind mit der günstigen Prognose der Mutter vereint werden. Angesichts limitierter Datenlage müssen bei Dysgerminomen in der Schwangerschaft individuelle, interdisziplinäre Konzepte erstellt werden.

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Ovarian dysgerminoma in pregnancy: A case report and literature review

Cited by 32 publications

References 70 publications

Germinal Ovarian Tumors In Reproductive Age Women: Fertility-Sparing And Outcome

Germinal Ovarian Tumors In Reproductive Age Women: Fertility-Sparing And Outcome

Pregnancy with giant ovarian dysgerminoma

Management Unterbauchraumforderungen in der Schwangerschaft – Fallbeschreibung eines extraovariell-intraabdominalen Dysgerminoms mit Überblick über die Literatur

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