Nematodes as Models for the Study of the Regulation of Activity of Pglycoproteins in Multidrug Resistance (MDR)

Abstract

Alterations in drug transport are a major cause of chemotherapy failures due to nonspecific resistance mechanisms. These mechanisms involve several ABC transporter proteins among which the P-glycoproteins have been the most extensively studied in vertebrates. Increased Pgp expression and/or activity in organisms leads to resistance to many chemically unrelated compounds and therapeutic agents. Such resistance has been observed in cancer and in other diseases due to infectious and parasitic pathogens. Most of the available information on these transporters has been obtained from genetic analyses, although useful data for understanding the cellular mechanisms of such resistance remains limited. As resistance affects several types of organism comparative information on the function and activity of these cellular pumps in various biological environments would be welcome. As such, nematodes represent a possible model. Recent data have been obtained for efflux function and modulation by different molecules in these invertebrates. The observed data are summarized here and the future of these studies is discussed.

Bioterr Labitech, un nuevo fitonematicida a base de benzimidazol

“…El benzimidazol, una vez en contacto con el nemátodo, sea afuera, en el suelo o dentro en la raíz, probablemente es absorbido al sistema muscular del parásito, provocando contracciones y relajaciones seguidas de parálisis debido a la inhibición enzimática del ácido fumárico o succínico con incapacidad para metabolizar la glucosa muscular. Interacciones del benzimidazol o inclusive del excipiente úrea amoniacal, con las glicoproteínas o con los esteroles de las membranas del parásito (16), podría anular sus resistencias y causar parálisis neuromuscular (17). Estos posibles efectos biomoleculares podrían convertirse en herramientas para estudiar expresiones genéticas neuronales en sistemas conservativos parasitarios relativamente menos complicados (3).…”

Control de nemátodos en maracuyá usando benzimidazoles en ácidos húmicos

“…Sin tratamiento Tratados desencadenar en catástrofes metabólicas suficientes como para causar su mortalidad (16). La poca mortalidad observada en los saprófitos después del tratamiento, también resulta interesante (Tabla 1).…”