Neglected tropical diseases in the genomics era: re-evaluating the impact of new drugs and mass drug administration

Croft, Simon L.

doi:10.1186/s13059-016-0916-1

Cited by 10 publications

(7 citation statements)

References 54 publications

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“…We have shown in this study that SCAMK s were very conserved both in structures and in numbers among Leishmania and Trypansosoma spp.. Considering its very conserved evolutionary pattern, we believed that SCAMKs are very promising candidate targets for treating diseases by Leishmania and Trypansosoma spp., as it has proved that genomics can lead to the development of treatments for these neglected tropical diseases today and in the future [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of a novel fused gene family implicates convergent evolution in eukaryotic calcium signaling

et al. 2018

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BackgroundBoth calcium signals and protein phosphorylation responses are universal signals in eukaryotic cell signaling. Currently three pathways have been characterized in different eukaryotes converting the Ca2+ signals to the protein phosphorylation responses. All these pathways have based mostly on studies in plants and animals.ResultsBased on the exploration of genomes and transcriptomes from all the six eukaryotic supergroups, we report here in Metakinetoplastina protists a novel gene family. This family, with a proposed name SCAMK, comprises SnRK3 fused calmodulin-like III kinase genes and was likely evolved through the insertion of a calmodulin-like3 gene into an SnRK3 gene by unequal crossover of homologous chromosomes in meiosis cell. Its origin dated back to the time intersection at least 450 million-year-ago when Excavata parasites, Vertebrata hosts, and Insecta vectors evolved. We also analyzed SCAMK’s unique expression pattern and structure, and proposed it as one of the leading calcium signal conversion pathways in Excavata parasite. These characters made SCAMK gene as a potential drug target for treating human African trypanosomiasis.ConclusionsThis report identified a novel gene fusion and dated its precise fusion time in Metakinetoplastina protists. This potential fourth eukaryotic calcium signal conversion pathway complements our current knowledge that convergent evolution occurs in eukaryotic calcium signaling.Electronic supplementary materialThe online version of this article (10.1186/s12864-018-4685-y) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Identification of a novel fused gene family implicates convergent evolution in eukaryotic calcium signaling

et al. 2018

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“…Moreover, in order to guarantee the success of drug discovery/repositioning in the fight against trypanosomatids, we have to generate high-quality data in many endemic countries (including field strains, drug-resistant strains, etc. ), and to do so, we have to effectively increase the engagement of endemic countries in the R&D process [ 159 ].…”

Section: Perspectives and Concluding Remarksmentioning

confidence: 99%

Of Drugs and Trypanosomatids: New Tools and Knowledge to Reduce Bottlenecks in Drug Discovery

Bhattacharya

Corbeil

Monte-Neto

et al. 2020

Genes

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Leishmaniasis (Leishmania species), sleeping sickness (Trypanosoma brucei), and Chagas disease (Trypanosoma cruzi) are devastating and globally spread diseases caused by trypanosomatid parasites. At present, drugs for treating trypanosomatid diseases are far from ideal due to host toxicity, elevated cost, limited access, and increasing rates of drug resistance. Technological advances in parasitology, chemistry, and genomics have unlocked new possibilities for novel drug concepts and compound screening technologies that were previously inaccessible. In this perspective, we discuss current models used in drug-discovery cascades targeting trypanosomatids (from in vitro to in vivo approaches), their use and limitations in a biological context, as well as different examples of recently discovered lead compounds.

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“…Un ejemplo que ilustra lo anterior es lograr investigaciones con equipos interdisciplinarios como se hizo para malaria y hepatitis C. La malaria cuenta en la actualidad con el desarrollo de nuevos fármacos (67), este adelanto ha sido posible gracias a la unión de la industria, las asociaciones público-privadas y la academia. Con respecto a la hepatitis C, el reciente desarrollo exitoso de una serie de nuevos fármacos y combinaciones de fármacos muestra que cuando el conocimiento, el esfuerzo, las habilidades, las instalaciones y la inversión se combinan entre la academia y la industria, los problemas pueden resolverse rápidamente (68,69).…”

Section: Investigaciónunclassified

Propuestas bioéticas frente a los problemas sociales y éticos que generan las enfermedades infecciosas desatendidas

Saenz

Ruggiero

2019

pers. bioet

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Este artículo de revisión se centra en el tema de las enfermedades infecciosas desatendidas (EID), grupo de 18 patologías de carácter incapacitante, a veces mortales y frecuentemente deformantes, que prevalecen en poblaciones de Asia, África y en las zonas tropicales de Sur América. Mediante una revisión bibliográfica se plantean los elementos que se relacionan con estas enfermedades, se categorizan y se analizan a la luz de la Declaración Universal sobre Bioética y Derechos Humanos de 2005, en cuanto a igualdad, justicia y equidad, el enfoque de no discriminación y estigmatización, responsabilidad social y salud. A lo largo de la revisión se concluye que la problemática alrededor de las EID es multifactorial y se presentan propuestas, desde una mirada de la bioética centrada en el respeto por la dignidad de la persona y de las poblaciones afectadas, para mitigar y solucionar la atención a partir de estrategias posibles que aborden determinantes sociales. Se propone incluir la bioética en el debate sobre la atención de las EID para analizar los problemas y examinar soluciones por medio de proyectos de investigación transdisciplinaria que impliquen un trabajo colaborativo y formativo entre las comunidades afectadas, entidades gubernamentales y profesionales de la salud y de las ciencias veterinarias.

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Neglected tropical diseases in the genomics era: re-evaluating the impact of new drugs and mass drug administration

Abstract: Simon Croft answers Genome Biology’s questions on ways to approach neglected tropical diseases in the genomics era, including re-evaluating the impact of new drugs and mass drug administration.

Cited by 10 publications

References 54 publications

Identification of a novel fused gene family implicates convergent evolution in eukaryotic calcium signaling

Identification of a novel fused gene family implicates convergent evolution in eukaryotic calcium signaling

Of Drugs and Trypanosomatids: New Tools and Knowledge to Reduce Bottlenecks in Drug Discovery

Propuestas bioéticas frente a los problemas sociales y éticos que generan las enfermedades infecciosas desatendidas

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