Neglected and emerging fungal infections: review of hyalohyphomycosis by Paecilomyces lilacinus focusing in disease burden, in vitro antifungal susceptibility and management

Antas, Paulo Renato Zuquim; Brito, Marcelly M. S.; Peixoto, Edison Carvalho Sandoval; Ponte, Carlos G.G.; Borba, Cíntia M.

doi:10.1016/j.micinf.2011.08.004

Cited by 33 publications

(69 citation statements)

References 67 publications

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“…Mariana Lima Perazzini Peixoto [1] , Dilvani Oliveira Santos [2] , Ivy de Castro Campos de Souza [2] , Eloah Christina Lyrio Neri [2] , Danielly Correa Moreira de Sequeira [1] , Paula Mello De Luca [3] and Cíntia de Moraes Borba [1] [1]. Laboratório de Taxonomia, Bioquímica e Bioprospecção de Fungos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ.…”

Section: Interaction Of An Opportunistic Fungus Purpureocillium Lilacunclassified

“…Laboratório de Taxonomia, Bioquímica e Bioprospecção de Fungos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ. [2]. Laboratório de Biopatógenos e Ativação Celular, Universidade Federal Fluminense, Niterói, RJ.…”

Section: Interaction Of An Opportunistic Fungus Purpureocillium Lilacunclassified

“…Currently, it is considered an important opportunistic pathogen in both immunocompromised and immunocompetent hosts 2,3 . It has been found parasitizing insects and nematodes, and hence, some researchers have described a potential use of this fungus as a biocontrol agent 4 .…”

Section: Interaction Of An Opportunistic Fungus Purpureocillium Lilacmentioning

confidence: 99%

“…In this condition, the fungi are observed in the affected tissues as septate hyphae with pigmentless cell walls 6,7 . Most clinical manifestations of P. lilacinum hyalohyphomycosis are associated with ocular, cutaneous, or subcutaneous infections and the major risk factors are organ transplantations, corticosteroid therapy, primary immunodeficiency, diabetes mellitus, acquired immunodefi ciency syndrome, intraocular lens implantation, and ophthalmic surgery 2,3,8,9 . No effective treatment has been established for this infection, and antifungal agents, including amphotericin B, fl ucytosine, and fl uconazole, have often provided unsatisfactory results 3 .…”

Section: Interaction Of An Opportunistic Fungus Purpureocillium Lilacmentioning

confidence: 99%

“…However, some of the so-called new azoles, such as posaconazole, ravuconazole, and voriconazole, have recently demonstrated good activity against P. lilacinum in vitro 10 . In many cases, a combination of P. lilacinum conidia developed the infection: fungal structures were observed and fungal cells were recovered from different organs 2,11 . These data indicate the need of additional studies to better comprehend the real invasive capability of P. lilacinum.…”

Section: Interaction Of An Opportunistic Fungus Purpureocillium Lilacmentioning

confidence: 99%

See 4 more Smart Citations

Interaction of an opportunistic fungus Purpureocillium lilacinum with human macrophages and dendritic cells

Peixoto

Santos

Souza

et al. 2014

Rev. Soc. Bras. Med. Trop.

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Section: Interaction Of An Opportunistic Fungus Purpureocillium Lilacunclassified

Section: Interaction Of An Opportunistic Fungus Purpureocillium Lilacmentioning

confidence: 99%

Section: Interaction Of An Opportunistic Fungus Purpureocillium Lilacmentioning

confidence: 99%

Section: Interaction Of An Opportunistic Fungus Purpureocillium Lilacmentioning

confidence: 99%

See 3 more Smart Citations

Interaction of an opportunistic fungus Purpureocillium lilacinum with human macrophages and dendritic cells

Peixoto

Santos

Souza

et al. 2014

Rev. Soc. Bras. Med. Trop.

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Assessment of multi-contaminant exposure in a cancer treatment center: a 2-year monitoring of molds, mycotoxins, endotoxins, and glucans in bioaerosols

Heutte¹,

André²,

Arvis³

et al. 2016

Environ Monit Assess

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Indoor air quality in health care facilities is a major public health concern, particularly for immunocompromised patients who may be exposed to microbiological contaminants such as molds, mycotoxins, endotoxins, and (1,3)-ß-D-glucans. Over 2 years, bioaerosols were collected on a monthly basis in a cancer treatment center (Centre F. Baclesse, Normandy, France), characterized from areas where there was no any particular air treatment. Results showed the complexity of mycoflora in bioaerosols with more than 100 fungal species identified. A list of major strains in hospital environments could be put forward due to the frequency, the concentration level, and/or the capacity to produce mycotoxins in vitro: Aspergillus fumigatus, Aspergillus melleus, Aspergillus niger, Aspergillus versicolor, Cladosporium herbarum, Purpureocillium lilacinum, and Penicillium brevicompactum. The mean levels of viable airborne fungal particles were less than 30.530 CFU per m of air and were correlated to the total number of 0.30 to 20 μm particles. Seasonal variations were observed with fungal particle peaks during the summer and autumn. Statistical analysis showed that airborne fungal particle levels depended on the relative humidity level which could be a useful indicator of fungal contamination. Finally, the exposure to airborne mycotoxins was very low (only 3 positive samples), and no mutagenic activity was found in bioaerosols. Nevertheless, some fungal strains such as Aspergillus versicolor or Penicillium brevicompactum showed toxigenic potential in vitro.

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Use of Voriconazole for the Treatment of Paecilomyces lilacinus Cutaneous Infections: Case Presentation and Review of Published Literature

et al. 2013

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The fungus Paecilomyces lilacinus is a rare but emerging pathogen that causes severe human infections, especially in immunocompromised hosts. It is an important organism to identify due to its poor susceptibility to conventional antifungal drugs, including amphotericin B, itraconazole, and fluconazole. Oculomycosis and cutaneous infections are the two most common manifestations of P. lilacinus infections. Voriconazole has been used successfully to treat P. lilacinus endophthalmitis, but reports of skin and soft tissue infections treated with voriconazole are limited to six prior publications. Our immunocompromised patient had a subcutaneous P. lilacinus infection successfully treated with 3 months of voriconazole therapy.

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Neglected and emerging fungal infections: review of hyalohyphomycosis by Paecilomyces lilacinus focusing in disease burden, in vitro antifungal susceptibility and management

Cited by 33 publications

References 67 publications

Interaction of an opportunistic fungus Purpureocillium lilacinum with human macrophages and dendritic cells

Interaction of an opportunistic fungus Purpureocillium lilacinum with human macrophages and dendritic cells

Assessment of multi-contaminant exposure in a cancer treatment center: a 2-year monitoring of molds, mycotoxins, endotoxins, and glucans in bioaerosols

Use of Voriconazole for the Treatment of Paecilomyces lilacinus Cutaneous Infections: Case Presentation and Review of Published Literature

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