Negative prognostic influence of micropapillary pattern in stage IA lung adenocarcinoma

Tsubokawa, Norifumi; Mimae, Takahiro; Sasada, Shinsuke; Yoshiya, Tomoharu; Mimura, Takashi; Murakami, Shuji; Ito, Hiroyuki; Miyata, Yoshihiro; Nakayama, Haruhiko; Okada, Morihito

doi:10.1093/ejcts/ezv058

Cited by 43 publications

(32 citation statements)

References 25 publications

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“…recently reported the proportion of MPC‐positive tumours to be 14%, the population of their study was confined to clinical stage IA lung ADCs. Furthermore, lymph node metastasis was reported to be significantly more frequent in MPC‐positive tumours, which is similar to the findings reported here.…”

Section: Discussionsupporting

confidence: 91%

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Mucinous micropapillary pattern in lung adenocarcinomas: a unique histology with genetic correlates

et al. 2015

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Section: Discussionsupporting

confidence: 91%

“…Therefore, our incidence of MPC does not indicate over‐representation. Although Tsubokawa et al . recently reported the proportion of MPC‐positive tumours to be 14%, the population of their study was confined to clinical stage IA lung ADCs.…”

Section: Discussionmentioning

confidence: 99%

Mucinous micropapillary pattern in lung adenocarcinomas: a unique histology with genetic correlates

et al. 2015

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“…Nitadori et al (14) investigated surgically resected cases of small lung adenocarcinomas (≤2 cm) and indicated that a micropapillary component ≥5% was associated with an increased risk of recurrence, compared with a micropapillary component <5%. Tsubokawa et al (15) found that in stage IA patients with papillary and acinar predominant tumors, a micropapillary component ≥5% of the entire tumor negatively influenced survival. However, there was no difference in the prognosis of patients with micropapillary-positive and negative tumors with lepidic or solid predominant patterns.…”

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confidence: 99%

Prognostic contribution of non-predominant solid and micropapillary components in lung adenocarcinomas

2017

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“…On the basis of our and others' previous publications that demonstrated worse prognosis in patients with micropapillary (MIP) subtype tumors who had undergone limited resection compared with those who had undergone lobectomy [19, 21], we investigated the utility of mPS in this cohort of patients (Figure 4). Within each setting, patients with high mPS had significantly lower survival estimates ( P < 0.001).…”

Section: Resultsmentioning

confidence: 99%

Cell cycle progression score is a marker for five-year lung cancer-specific mortality risk in patients with resected stage I lung adenocarcinoma

et al. 2016

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Purpose: The goals of our study were (a) to validate a molecular expression signature (cell cycle progression [CCP] score and molecular prognostic score [mPS; combination of CCP and pathological stage {IA or IB}]) that identifies stage I lung adenocarcinoma (ADC) patients with a higher risk of cancer-specific death following curative-intent surgical resection, and (b) to determine whether mPS stratifies prognosis within stage I lung ADC histological subtypes.Methods: Formalin-fixed, paraffin-embedded stage I lung ADC tumor samples from 1200 patients were analyzed for 31 proliferation genes by quantitative RT-PCR. Prognostic discrimination of CCP score and mPS was assessed by Cox proportional hazards regression, using 5-year lung cancer-specific mortality as the primary outcome.Results: In multivariable analysis, CCP score was a prognostic marker for 5-year lung cancer-specific mortality (HR=1.6 per interquartile range; 95% CI, 1.14-2.24; P=0.006). In a multivariable model that included mPS instead of CCP, mPS was a significant prognostic marker for 5-year lung cancer-specific mortality (HR=1.77; 95% CI, 1.18-2.66; P=0.006). Five-year lung cancer-specific survival differed between low-risk and high-risk mPS groups (96% vs 81%; P<0.001). In patients with intermediate-grade lung ADC of acinar and papillary subtypes, high mPS was associated with worse 5-year lung cancer-specific survival (P<0.001 and 0.015, respectively), compared with low mPS.Conclusion: This study validates CCP score and mPS as independent prognostic markers for lung cancer-specific mortality and provides quantitative risk assessment, independent of known high-risk features, for stage I lung ADC patients treated with surgery alone.Oncotarget 35242 www.impactjournals.com/oncotarget

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Negative prognostic influence of micropapillary pattern in stage IA lung adenocarcinoma

Abstract: MPP has an effect on tumour malignancy and patients with tumours harbouring a higher ratio of MPP or papillary predominant subtypes have worse survival.

Cited by 43 publications

References 25 publications

Mucinous micropapillary pattern in lung adenocarcinomas: a unique histology with genetic correlates

Mucinous micropapillary pattern in lung adenocarcinomas: a unique histology with genetic correlates

Prognostic contribution of non-predominant solid and micropapillary components in lung adenocarcinomas

Cell cycle progression score is a marker for five-year lung cancer-specific mortality risk in patients with resected stage I lung adenocarcinoma

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