Prognostic contribution of non-predominant solid and micropapillary components in lung adenocarcinomas

Suzuki, Masaki; Yokose, Tomoyuki; Nakayama, Haruhiko

doi:10.21037/jtd.2017.03.15

Cited by 9 publications

(5 citation statements)

References 16 publications

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“…22 A few studies have revealed that minor components of solid and/or MP subtypes are associated with nodal metastasis and poor prognosis. [23][24][25][26][27] In our study, there were only four MP predominant cases, but MP components were found in 97 cases. As reported in a previous study, 23 we found patients with lung adenocarcinomas harboring MP components had shorter RFS and OS.…”

Section: Discussioncontrasting

confidence: 56%

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Prognostic impact of micropapillary component in patients with node‐negative subcentimeter lung adenocarcinoma: A Chinese cohort study

Yao

Zhu

et al. 2020

Thoracic Cancer

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Background: In this study, we investigated the prognostic significance of a micropapillary (MP) component in patients with subcentimeter lung adenocarcinoma. Methods: A total of 311 patients with subcentimeter lung adenocarcinoma who underwent surgical resection between January 2009 to December 2012 from seven medical centers were included. Recurrence-free survival (RFS) and overall survival (OS) were analyzed. Results: The five-year RFS was 79.8% in 97 (97/311, 31%) cases of adenocarcinoma with a MP component and 93.5% in the 214 (214/311, 69%) cases without. In multivariate analysis, MP was an independent risk factor for worse RFS (hazard ratio [HR], 3.73; 95% confidence interval [CI]: 1.87-7.42; P < 0.001) and OS (HR, 5.84; 95% CI: 2.20-15.49; P < 0.001). There was no significant difference among wedge resection, segmentectomy and lobectomy on RFS (P = 0.256) and OS (P = 0.103) in patients without MP. Regarding patients with a MP component, lobectomy achieved equivalent prognosis than segmentectomy, and both were better than wedge resection (P = 0.001). Conclusions: A MP component still suggest a poor prognosis in subcentimeter lung adenocarcinoma. Patients with subcentimeter lung adenocarcinoma with a MP component of 5% or greater treated with wedge resection were at higher risk of recurrence than patients treated with anatomical resection.

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Section: Discussioncontrasting

confidence: 56%

“…Lung adenocarcinoma usually contains complex mixtures of different histological subtypes 22 . A few studies have revealed that minor components of solid and/or MP subtypes are associated with nodal metastasis and poor prognosis 23–27 . In our study, there were only four MP predominant cases, but MP components were found in 97 cases.…”

Section: Discussioncontrasting

confidence: 46%

Prognostic impact of micropapillary component in patients with node‐negative subcentimeter lung adenocarcinoma: A Chinese cohort study

Yao

Zhu

et al. 2020

Thoracic Cancer

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“…These results indicate that the presence of the fetal-type component, regardless of its proportion (if at least 5%), is an independent poor prognostic factor in lung adenocarcinomas. This is similar to the prognostic relevance of nonpredominant solid and micropapillary patterns in lung adenocarcinomas [15][16][17][18]. The current WHO classification of lung tumors describes that high-grade fetal adenocarcinoma is rendered as a diagnosis when this component is predominant [2].…”

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confidence: 60%

Pulmonary adenocarcinoma with high-grade fetal adenocarcinoma component has a poor prognosis, comparable to that of micropapillary adenocarcinoma

et al. 2018

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Fetal adenocarcinoma is a rare variant of lung adenocarcinoma, which is subcategorized into low-grade and high-grade forms. High-grade fetal adenocarcinoma confers worse prognosis than low-grade fetal adenocarcinoma, but the prognostic differences between high-grade fetal adenocarcinoma and conventional lung adenocarcinoma are unknown. We reviewed tissue sections of 3719 cases of surgically resected primary lung cancers and found 53 lung cancers with a high-grade fetal adenocarcinoma component. We analyzed their clinicopathological and immunohistochemical features, and performed a prognostic analysis of adenocarcinomas with the fetal-type component. We further analyzed the prognostic differences between adenocarcinomas with the fetal-type component and conventional adenocarcinomas without the fetal-type component. Lung cancers with the fetal-type component predominantly occurred in elderly men with a smoking history. Twenty-nine patients had stage I disease, 13 patients had stage II, and 11 patients had stage III. The fetal-type histology was combined with conventional-type adenocarcinoma (41 cases), squamous cell carcinoma (5 cases), large cell neuroendocrine carcinoma (5 cases), enteric adenocarcinoma (2 cases), and small cell carcinoma (1 case). The fetal-type component showed immunopositivity for α-fetoprotein (39%), glypican-3 (37%), and SALL4 (17%). The 5-year overall survivals of fetal-type-predominant and fetal-type-nonpredominant patients were 44 and 56%, respectively (P = 0.962). The 5-year overall survivals of lepidic-, acinar-, papillary-, solid-, and micropapillary-predominant adenocarcinomas, invasive mucinous adenocarcinomas, and adenocarcinomas with the fetal-type component were 94, 82, 77, 69, 57, 83, and 41%, respectively (P < 0.001). Univariate and multivariate analyses showed that adenocarcinomas with the fetal-type component had a significantly lower overall survival rate than the other histological subtypes, except for the micropapillary-predominant subtype. Our study demonstrated that adenocarcinomas with the fetal-type component had a poor prognosis that was comparable to that of micropapillary adenocarcinoma. The presence of the high-grade fetal adenocarcinoma component in lung adenocarcinomas is an important prognostic marker.

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“…Combining low-dose CT and potential biomarkers with optimal discriminating power in high risk populations for lung cancer may optimize the effectiveness for the early detection of lung cancer [ 42 ].Lung adenocarcinoma with micropapillary and/or solid patterns has been reported to have the worst prognosis, and in our study, the samples from patients with this type of LC showed higher levels of hsa_circ_0000190 ( p = 0.0028) ( Figure 5 B). This result indicates that a higher level of hsa_circ_0000190 is positively correlated with histological types associated with a worse prognosis [ 43 ]. The average copy numbers of hsa_circ_0000190 gradually decreased after patients received effective therapy ( Figure 6 D–F).…”

Section: Discussionmentioning

confidence: 99%

Plasma Level of Circular RNA hsa_circ_0000190 Correlates with Tumor Progression and Poor Treatment Response in Advanced Lung Cancers

Luo

Yang

Chien

et al. 2020

Cancers

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Lung cancer (LC) causes the majority of cancer-related deaths. Circular RNAs (circRNAs) were reported to play roles in cancers by targeting pro- and anti-oncogenic miRNAs. However, the mechanisms of circRNAs in LC progression and their prognostic value of treatment response remain unclear. By using next generation sequencing (NGS) of LC cell lines’ transcriptomes, we identified highly overexpressed hsa_circ_0000190 and hsa_circ_000164 as potential biomarkers. By using the highly sensitive RT-ddPCR method, these circRNAs were shown to be secreted by cell lines and were detected in human blood. Clinical validation by RT-ddPCR was carried out on 272 (231 LC patients and 41 controls) blood samples. Higher hsa_circ_0000190 levels were associated with larger tumor size (p < 0.0001), worse histological type of adenocarcinoma (p = 0.0028), later stage (p < 0.0001), more distant metastatic organs (p = 0.0039), extrathoracic metastasis (p = 0.0004), and poor survival (p = 0.047) and prognosis. Using liquid biopsy-based RT-ddPCR, we discovered the correlation between increased hsa_circ_0000190 plasma level (p < 0.0001) and higher programmed death-ligand 1 (PD-L1) level in tumor (p = 0.0283). Notably, long-term follow-up of the immunotherapy treated cases showed that upregulated plasma hsa_circ_0000190 level correlated with poor response to systemic therapy and immunotherapy (p = 0.0002, 0.0058, respectively). Secretory circRNAs are detectable in blood by LB-based RT-ddPCR and may serve as blood-based biomarkers to monitor disease progression and treatment efficacy.

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Prognostic contribution of non-predominant solid and micropapillary components in lung adenocarcinomas

Cited by 9 publications

References 16 publications

Prognostic impact of micropapillary component in patients with node‐negative subcentimeter lung adenocarcinoma: A Chinese cohort study

Prognostic impact of micropapillary component in patients with node‐negative subcentimeter lung adenocarcinoma: A Chinese cohort study

Pulmonary adenocarcinoma with high-grade fetal adenocarcinoma component has a poor prognosis, comparable to that of micropapillary adenocarcinoma

Plasma Level of Circular RNA hsa_circ_0000190 Correlates with Tumor Progression and Poor Treatment Response in Advanced Lung Cancers

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