Negative Pressure Wound Therapy for Burns

Kantak, Neel A.; Mistry, Riyam; Varon, David E.; Halvorson, Eric G.

doi:10.1016/j.cps.2017.02.023

Cited by 51 publications

(44 citation statements)

References 18 publications

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“…NPWT has been utilised as a ubiquitous wound management resource and is widely used for acute open wounds, burn wounds, and chronic wounds, as well as infected wounds (Stannard et al 2009; Kantak et al 2017; Chiang et al 2017; Lo Torto et al 2017). The goals of our study were to utilise an in vitro model and bacteria biofilm model to determine whether NPWT inhibits P. aeruginosa motility, reduces biofilm formation and virulence factors in wounds, and to assess if these effects counteract impaired wound healing.…”

Section: Discussionmentioning

confidence: 99%

Negative pressure wound therapy reduces the motility of Pseudomonas aeruginosa and enhances wound healing in a rabbit ear biofilm infection model

Wang

et al. 2018

Antonie van Leeuwenhoek

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Pseudomonas aeruginosa motility, virulence factors and biofilms are known to be detrimental to wound healing. The efficacy of negative pressure wound therapy (NPWT) against P. aeruginosa has been little studied, either in vitro or in vivo. The present study evaluated the effect of negative pressure (NP) on P. aeruginosa motility in vitro, and the effect of NPWT on virulence factors and biofilms in vivo. P. aeruginosa motility was quantified under different levels of NP (atmospheric pressure, − 75, − 125, − 200 mmHg) using an in vitro model. Swimming, swarming and twitching motility were significantly inhibited by NP (− 125 and − 200 mmHg) compared with atmospheric pressure (p = 0.05). Virulence factors and biofilm components were quantified in NPWT and gauze treated groups using a rabbit ear biofilm model. Biofilm structure was studied with fluorescence microscopy and scanning electron microscopy. Additionally, viable bacterial counts and histological wound healing parameters were measured. Compared with the control, NPWT treatment resulted in a significant reduction in expression of all virulence factors assayed including exotoxin A, rhamnolipid and elastase (p = 0.01). A significant reduction of biofilm components (eDNA) (p = 0.01) was also observed in the NPWT group. The reduction of biofilm matrix was verified by fluorescence- and scanning electron-microscopy. NPWT lead to better histologic parameters (p = 0.01) and decreased bacterial counts (p = 0.05) compared with the control. NPWT treatment was demonstrated to be an effective strategy to reduce virulence factors and biofilm components, which may explain the increased wound healing observed.

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Section: Discussionmentioning

confidence: 99%

Negative pressure wound therapy reduces the motility of Pseudomonas aeruginosa and enhances wound healing in a rabbit ear biofilm infection model

Wang

et al. 2018

Antonie van Leeuwenhoek

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“…Irrigation with HOCL should now be considered instrumental when the ROCF NPWT is used and irrigation is required to further treat the heavily exudative wounds or wounds that have heavy prokaryotic contamination before any attempt at closure. Other studies have also shown the benefit of HOCl solution using Vashe® wound therapy as the principal wound solution for dressings in non-healing and malodorous wounds [11-12].…”

Section: Discussionmentioning

confidence: 99%

The Use of V.A.C. VERAFLO CLEANSE CHOICE in the Burn Population

Matthews

Hechtman

Quan

et al. 2018

Cureus

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Negative pressure wound therapy (NPWT) is routinely used in the treatment of acute and chronic wounds. The technology continues to evolve with improved results NPWT is routinely used at the Arizona Burn Center and the addition of the V.A.C. VERAFLO CLEANSE CHOICETM with its reticulated open foam device has been used with promising results in a variety of complicated wounds. We present a case series involving the use of this negative pressure wound therapy device and irrigation in burn and necrotizing soft tissue patients treated at the Arizona Burn Center.

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“…[249][250][251] However, a more recent literature review of a modified form of TNP found it to be a safe and effective temporary covering following early excision, particularly patients with large burns, with benefits of valuable quantification of wound exudate, reduction of opioid requirements, and lower risk of bacterial contamination. 252 Regarding other topical therapies, some of which remain in use, there is clear evidence of a lack of effect for various types of honey 253,254 and aloe vera 255,256 as well as platelet-rich plasma, 257,258 curcurmin, 259 fibroblast growth factor (FGF)-10, dermatan sulfate, 260 ultraviolet C irradiation, 261 and chitosan. 262 Antibiotics.…”

Section: Perioperative Managementmentioning

confidence: 99%

A Critical Update of the Assessment and Acute Management of Patients with Severe Burns

Lang

Zhao²,

Kim

et al. 2019

Advances in Wound Care

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Burns are debilitating, life threatening, and difficult to assess and manage. Recent advances in assessment and management have occurred since a comprehensive review of the care of patients with severe burns was last published, which may influence research and clinical practice. Recent Advances: Recent advances have occurred in the understanding of burn pathophysiology, which has led to the identification of potential biomarkers of burn severity, such as protein C. There is new evidence about the potential superiority of natural colloids over crystalloids during fluid resuscitation, and new evidence about components of initial and perioperative management, including an improved understanding of pain following burns. Critical Issues: The limitations of the clinical examination highlight the need for imaging and biomarkers to assist in estimations of burn severity. Fluid resuscitation reduces mortality, although there is conjecture over the ideal method. The subsequent perioperative period is associated with significant morbidity and the evidence for preventing and treating pain, infection, and fluid overload while maximizing wound healing potential is described. Future Directions: Promising developments are ongoing in imaging technology, histopathology, biomarkers, and wound healing adjuncts such as hyperbaric oxygen therapy, topical negative pressure therapy, stem cell treatments, and skin substitutes. The greatest benefit from further research on management of patients with burns would most likely be derived from the elucidation of optimal fluid resuscitation protocols, pain management protocols, and surgical techniques from randomized controlled trials.

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Negative Pressure Wound Therapy for Burns

Cited by 51 publications

References 18 publications

Negative pressure wound therapy reduces the motility of Pseudomonas aeruginosa and enhances wound healing in a rabbit ear biofilm infection model

Negative pressure wound therapy reduces the motility of Pseudomonas aeruginosa and enhances wound healing in a rabbit ear biofilm infection model

The Use of V.A.C. VERAFLO CLEANSE CHOICE in the Burn Population

A Critical Update of the Assessment and Acute Management of Patients with Severe Burns

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