Negative pressure wound therapy for chronic venous ulcer: a randomized-controlled study

Alkhateep, Yahia; Zaid, Nehad; Fareed, Abdelmieniem

doi:10.4103/ejs.ejs_147_17

Cited by 5 publications

(5 citation statements)

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“…In addition, with the reduced period of therapy and early mobility, NPWT restricts the requirement for post-operative physiotherapy. [15][16][17]22 In the present study, only four patients in the NPWT Group experienced scar contracture who underwent skin grafting, while no complications such as worsening infection or severe bleeding which could be specifically related to NPWT use were observed. Scar contracture occurred in four patients in the NPWT Group.…”

Section: Discussionmentioning

confidence: 47%

“…The research by Jones et al, 16 revealed similar results; the meantime of NPWT was 22.5 days which is lesser than the use of conven- tional therapy for six weeks for infected wound. 3,17,18 In another study by Tarek Abulezz, also showed the meantime for granulation tissue in NPWT was significantly lesser than conventional therapy (18.5 days vs 28 days). 19 Blume et al in their study found a significant reduction in wound size in the NPWT Group as compared to Controls (43.2% vs 28.9%).…”

Section: Discussionmentioning

confidence: 96%

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Effect of Negative Pressure Wound Therapy for Soft Tissue Injuries of Foot and Ankle in Patients at a Tertiary Care Hospital

Khursheed

Khan

Hyder

et al. 2022

PAFMJ

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Objective: To determine the effect of Negative Pressure Wound Therapy (NPWT) in patients with foot and/or ankle injury compared with conventional dressing techniques. Study Design: Randomized controlled trial (Trial No: NCT04569305). Place and Duration of Study: Department of Plastic Surgery, Dr Ruth K.M. Pfau Civil Hospital, Karachi Pakistan, from Dec 2019 to Oct 2020. Methodology: All patients with foot and ankle injury resulting in soft tissue injury with or without bones and tendons exposed were included. Thirty-five patients were randomized into the NPTW-Group and 35 into the Conventional Treatment Group using the lottery method. NPTW was applied to an injured foot and ankle area after debridement and cleaning the necrosed tissue. The effect of the technique was assessed by measuring the wound surface area covered with healthy granulation tissue measured in a centimetre square on follow-up. Results: Mean wound grade at the start of treatment was estimated as 3.20±0.71 in the NPWT-Group and 3.14±0.73 in the Control-Group, and at the end of treatment as 1.20±0.53 in the NPWT-Group and 1.71±0.78 in the Control Group. The mean wound size at the start of treatment was estimated as 52.74±21.92 cm2 in the NPWT-Group and 54.08±23.28 cm2 in Controls.At the end of treatment, an average wound size was estimated as 21.61±13.46 in NPTW and 30.40±16.50 in controls. NPTW significantly reduced wound grade and size more effectively than the conventional technique (p<0.05). Conclusion: Negative pressure wound therapy was more effective for soft tissue injury of the foot and/or ankle injury than the conventional............

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Section: Discussionmentioning

confidence: 47%

Section: Discussionmentioning

confidence: 96%

Effect of Negative Pressure Wound Therapy for Soft Tissue Injuries of Foot and Ankle in Patients at a Tertiary Care Hospital

Khursheed

Khan

Hyder

et al. 2022

PAFMJ

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“…This is achieved through several mechanisms: reduction of local edema as well as reduction of the number of bacteria, inflammatory mediators and wound exudates. NPWT promotes angiogenesis, promotes tissue perfusion, stimulates tissue granulation, causes wound shrinking, and contraction of its edges [47,57]. Platelet-rich plasma (PRP) or autologous platelet-rich plasma is a suspension of platelets obtained from whole blood [58].…”

Section: Levels Of Compression Indicationsmentioning

confidence: 99%

Perspective Chapter: Diagnosis and Treatment of Venous Leg Ulcer

Karanikolić¹,

Karanikolić²

2023

Wound Healing - Recent Advances and Future Opportunities

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Venous leg ulcer (VLU) represent a pathological tissue change in the form of a defect in the lower leg which occurs as a complication of chronic venous insufficiency. The prevalence of VLUs varies between 1.5–3% in the total population and 4–5% in persons over the age of 80. Venous ulcer is usually localized on the inner side of the lower third of the leg, oval, circular or irregular in shape. It is usually fibrous or covered with fresh granules that bleed heavily to the touch. It is very important to have a comprehensive clinical examination at the very beginning. Subsequent non-invasive and sometimes invasive tests may be indicated for diagnosis and treatment planning. Inadequate diagnosis results in inadequate therapy. The goal of therapy is complete restitution of the tissue defect and prevention of recurrence. The three basic elements of VLUs therapy are: local therapy, compression therapy and surgical treatment. If VLUs do not heal despite the application of standard therapeutic modalities, there are opportunities to apply new treatment technologies. The modern approach to the treatment of VLUs is based on the application of various biophysical interventions and medical devices.

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“…Moreover, NPWT provides angiogenesis induction, promotes tissue perfusion, stimulates tissue granulation, causes wound shrinking, and contraction of its edges. These mechanisms improve topical wound state and facilitate the healing process [ 11 , 18 , 31 , 32 ]. Other names for this therapy found in the literature are: vacuum-assisted closure (VAC), vacuum sealing technique (VST), vacuum pack therapy, sealed surface wound suction (SSS), subatmospheric pressure dressing (SPD), foam suction dressing, or sealing aspirative therapy [ 33 ].…”

Section: Negative Pressure Wound Therapymentioning

confidence: 99%

Venous Leg Ulcers: Advanced Therapies and New Technologies

2021

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The prevalence of venous leg ulcers (VLUs) differs between 1.5% and 3% in the general population. The challenge in treating VLUs is common recurrence. Moreover, VLUs can be resistant to healing, despite appropriate treatment. In these cases, advanced wound therapies should be considered. The number of new technologies, applied in VLUs treatment, has increased in the last years. These therapies include biophysical interventions such as ultrasound therapy, electrical stimulations, electromagnetic therapy, or phototherapy. Furthermore, stem cell therapies, biologic skin equivalents, platelet-rich plasma therapy, oxygen therapies, anti-TNF therapy, or negative pressure wound therapy are advanced venous ulcer therapeutic methods that may support the standard of care. Medical devices, such as a muscle pump activator, or intermittent pneumatic compression device, may be especially useful for specific subgroups of patients suffering from VLUs. Some of the above-mentioned technologies require broader evidence of clinical efficacy and are still considered experimental therapies in dermatology.

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Negative pressure wound therapy for chronic venous ulcer: a randomized-controlled study

Cited by 5 publications

References 1 publication

Effect of Negative Pressure Wound Therapy for Soft Tissue Injuries of Foot and Ankle in Patients at a Tertiary Care Hospital

Effect of Negative Pressure Wound Therapy for Soft Tissue Injuries of Foot and Ankle in Patients at a Tertiary Care Hospital

Perspective Chapter: Diagnosis and Treatment of Venous Leg Ulcer

Venous Leg Ulcers: Advanced Therapies and New Technologies

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