Negative pressure wound therapy as an adjunct in healing of chronic wounds

Langer, Vijay; Bhandari, PS; Rajagopalan, S; Mukherjee, M. K.

doi:10.1111/iwj.12132

Cited by 23 publications

(14 citation statements)

References 30 publications

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“…Langer et al performed a prospective study on the adjunctive role of NPWT (Negative-pressure wound therapy) in the healing of chronic wounds. 44 A significant observation from this study is that, in their study group of 60 patients, they identified that coverage in the form of a flap was required at presentation in 63.33% of patients with chronic wounds. Hence, we can infer that where available, early referral to reconstructive services may shorten the course and improve the outcome in chronic wounds.…”

Section: Discussionmentioning

confidence: 77%

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<p>A Current Overview of Chronic Wounds Presenting to a Plastic Surgery Unit in Central India</p>

Khan¹,

Cheruvu²,

Krishna³

et al. 2020

CWCMR

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Purpose: To analyze the demographic, clinical, and microbiological profile of patients presenting to our unit with chronic wounds of various etiologies with an intent to give a current overview of chronic wounds. Patients and Methods: We performed a prospective observational study of patients presenting with chronic wounds from October 2018 to September 2019. The study was conducted at the Department of Burns and Plastic Surgery of a tertiary care institute in a nonmetropolitan city in Central India. A total of 103 patients were included in the study. Data collected from the patients included demographic details, history, clinical features, and relevant laboratory reports. Wound swabs obtained by Levine's technique were sent for culture and sensitivity studies. Treatment was instituted according to the clinical picture and modified if necessary. Progress was monitored until the wound healed, either by conservative management or by surgical intervention. Patients were followed up for six months thereafter. Results: Most of the patients presented with lower limb wounds (n=81, 78.64%). Swab specimens from 103 wounds were cultured. Among the isolates, gram-negative organisms were more common than gram-positive organisms. Staphylococcus aureus was the most common species isolated, followed by Pseudomonas aeruginosa. The frequency of infections caused by other gram-negative organisms like Klebsiella pneumoniae, Escherichia coli, and Proteus mirabilis was on the rise. There were significant differences in the patterns of antimicrobial resistance in our patients. Sharp debridements were required in almost all cases for wound preparation. Most of the patients (n=74, 71.84%) underwent surgical intervention for achieving wound closure. Split-thickness skin grafting (STSG) was the most common surgical intervention performed (n=45, 43.68% patients), followed by local and distant flaps. Conclusion: Our study gives a current overview of the causes, clinical presentation, prevalent microbial flora, and their antibiotic susceptibilities prevalent in chronic wounds presenting to our unit. Treatments administered are discussed with emphasis on the different reconstructions performed.

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Section: Discussionmentioning

confidence: 77%

“…Further, in this study, after the institution of NPWT, 60% of the patients had wound healing by secondary intention, and 40% of patients required split-thickness skin grafts. 44 In our study, STSG was performed in 43.68% of the patients.…”

Section: Discussionmentioning

confidence: 94%

<p>A Current Overview of Chronic Wounds Presenting to a Plastic Surgery Unit in Central India</p>

Khan¹,

Cheruvu²,

Krishna³

et al. 2020

CWCMR

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“…Since the introduction of NPWT in 1997, its use has been extended for managing many types of wounds including diabetic foot, pressure ulcers, open abdomen, chest wounds, skin grafts and traumatic lower extremity wounds . It is now considered to be one of the major advanced treatments for healing complicated wounds.…”

Section: Discussionmentioning

confidence: 99%

Cyclic negative pressure wound therapy: an alternative mode to intermittent system

Lee

Ben-Nakhi

Park

et al. 2013

International Wound Journal

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The purpose of this study was to develop and test a novel mode of negative pressure wound therapy (NPWT) that minimises pain while preserving the efficacy in wound healing. A porcine model was used in this study. Wounds were generated in animals and treated with either simple dressing or various treatment modes of NPWT. The wound volume, perfusion level and vasculature status were analysed and compared among different groups. Clinical application was performed to evaluate the level of pain occurring when negative pressure is applied. Among the NPWT groups, the Cyclic-50 group showed most decrement in wound volume, even though statistical relevance was not found (P = 0·302). The perfusion level was significantly increased in the Cyclic-50 group compared with the Intermittent group (P < 0·001) and the Cyclic-100 group (P = 0·004). Evaluation of blood vessel formation revealed that the Cyclic-50 group showed the highest number of vasculature with statistical significance (P < 0·001). In clinical application, the cyclic group showed significant decrease in pain compared with the intermittent group (P = 0·001). The cyclic NPWT mode decreased patient discomfort while maintaining superior wound healing effects as the intermittent mode.

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“…Novel therapies include the use of platelet-rich plasma, negative pressure wound therapy (NPWT), and artificial dermis, among others. [ 11 – 13 ] These require surgical debridement and are minimally invasive with much better healing efficacy than conventional therapies. Plastic operations, such as skin and flap grafting, are invasive and require the sacrifice of healthy skin tissue, which has strict indications.…”

Section: Introductionmentioning

confidence: 99%

Treatment of human chronic wounds with autologous extracellular matrix/stromal vascular fraction gel

et al. 2018

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Stem cell therapy is considered as the most promising treatment for chronic wounds. Extracellular matrix/stromal vascular fraction gel (ECM/SVF gel), an adipose-derived stem cell-based cytotherapy, has shown healing potential in experimental wounds in animal models. However, the effects of ECM/SVF gel on human chronic wounds have not been investigated. The aim of the present study is to investigate the therapeutic effect of ECM/SVF gel on human chronic wounds.Autologous ECM/SVF gel was prepared and used to treat patients with chronic wounds in clinics, with negative pressure wound therapy as the positive control. Wound healing rate per week and histological changes were performed.The average wound healing rate per week in the ECM/SVF gel group was 34.55 ± 11.18% compared with 10.16 ± 2.67% in the negative pressure wound therapy group (P < .001). Histological analysis with hematoxylin and eosin, Masson's trichrome staining, and CD31 immunohistochemistry showed less lymphocyte infiltration, more collagen accumulation, and more newly formed vessels in the ECM/SVF gel group treated skins compared to the control.ECM/SVF gel is an effective therapeutic option for chronic wound healing in clinics.

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Negative pressure wound therapy as an adjunct in healing of chronic wounds

Cited by 23 publications

References 30 publications

<p>A Current Overview of Chronic Wounds Presenting to a Plastic Surgery Unit in Central India</p>

<p>A Current Overview of Chronic Wounds Presenting to a Plastic Surgery Unit in Central India</p>

Cyclic negative pressure wound therapy: an alternative mode to intermittent system

Treatment of human chronic wounds with autologous extracellular matrix/stromal vascular fraction gel

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