Negative Pressure Dressing in the Management of Pyoderma Gangrenosum Ulcer

Comparison of negative pressure wound therapy and secondary intention healing after excision of acral lentiginous melanoma on the foot

“…However, SIH requires an extended period of healing time, and has a risk of developing infection; accordingly, it requires regular and frequent dressing changes to prevent infection. Since the advantages of NPWT using negative pressure devices to accelerate secondary healing were reported in 1997, 17,18 NPWT has been used as a tool for treating chronic wounds 19 and for fixation of skin grafts, 20 and has been applied for treating infectious diseases such as necrotizing fasciitis 21 and intractable skin ulcers such as pyoderma gangrenosum 22 …”

“…Since the advantages of NPWT using negative pressure devices to accelerate secondary healing were reported in 1997, 17,18 NPWT has been used as a tool for treating chronic wounds 19 and for fixation of skin grafts, 20 and has been applied for treating infectious diseases such as necrotizing fasciitis 21 and intractable skin ulcers such as pyoderma gangrenosum. 22 The key feature of NPWT that accelerates wound healing is the application of subatmospheric pressure on the upper and central areas of the skin defect. The physical force on the area induces tissue contraction 23 and the negative pressure reduces local interstitial tissue oedema.…”

Management of Pathergy in Pyoderma Gangrenosum: A Case Report & Literature Review

“…The ulcer edge is often worn and the surrounding skin is erythematous and indurated. Ulcers with pathergic lesions develop at the site of minor trauma, so surgery or debridement is contraindicated [4]. The epidemiology of Pyoderma is estimated to have an incidence rate of 3-10 per million population per year [5,6].…”

“…Complicated by the underlying systemic disease and immunosuppressive treatment, wound healing may take up till six months for epithelialization. Surgery is avoided unless the wound is infected with active exudation to prevent pathergy associated worsening [4].…”

Gauze‐based negative pressure wound therapy: a valid method to manage pyoderma gangrenosum

“…The currently available adjuvant surgery (7) includes aggressive ulcer excision, recipient site preparation, grafting of autologous cultured keratinocytes with or without topical treatment with hyaluronic acid derivatives and skin graft or muscle flap coverage. Recently, some reports (6,11,15,16,17) described the usage of the VAC system (KCI International, San Antonio, TX) with polyurethane foam in association with debridements (6), skin grafts or in association with hyperbaric oxygen and skin grafts (17). It was found to be a well-tolerated treatment that can be used alone until complete wound closure (16).…”