Negative Pressure Dressing in the Management of Pyoderma Gangrenosum Ulcer

Fluorescent Imaging as a Component of Diagnosing Pyoderma Gangrenosum: A Case Report

“…Several case studies and series have demonstrated success in treating PG ulcers using NPWT. [9][10][11] The negative pressure provided by vacuum-assisted closure devices counters natural tension on the wound from surrounding skin, bringing the edges of the wound closer together. 12 In addition, the subatmospheric pressure "pulls" fluid and stagnant material from the wound bed, keeping the area clean and reducing the risk of colonization and wound infection while maintaining a moist wound environment.…”

“…Several case studies and series have demonstrated success in treating PG ulcers using NPWT 9–11 . The negative pressure provided by vacuum-assisted closure devices counters natural tension on the wound from surrounding skin, bringing the edges of the wound closer together 12 .…”

Negative-pressure wound therapy as an adjunct to treating pyoderma gangrenosum

“…Negative-pressure wound therapy has been shown to be effective in re-epithelialisation in recalcitrant pyoderma gangrenosum. [5][6][7][8][9][10] This proposed to be due to granulation tissue formation and reduction of exudate resulting in control of bacterial load in ulcers. 10 In addition to standard negative-pressure systems, the use of portable negative-pressure wound systems has been shown to be effective for wound management in promoting healing.…”

The role of negative pressure wound therapy (NPWT) on the treatment of pyoderma gangrenosum: A systematic review and personal experience

“…According to our systematic review, few cases have a good evolution with the use of NPWT before starting immunosuppressive therapy or without association with immunosuppressive therapy. 8,15,[20][21][22][23][24][25][26][27] On the other hand, the absence of wound improvement after using the NPWT has also been described in the literature (Table 2). In most cases, this outcome occurred when NPWT was performed without association with systemic immunosuppressive therapy, which increases the likelihood of active disease, with an exacerbated inflammatory response.…”

“…Among the cases in which it was described, pressure levels greater than 125 mmHg were related to pain, while levels of 125 mmHg or less were not related to pain. 20,24,30,43,64,68,69 In Table 1, we summarized the studies including patients with PG treated with NPWT, but more detailed data can be accessed in Table S3. [70][71][72][73][74][75][76][77][78][79] As limitations of our review, we mention the publication bias and selective report that may have influenced the results.…”