Negative impact of leakage on survival of patients undergoing curative resection for advanced gastric cancer

Abstract

Postoperative inflammation due to leakage is a negative prognostic factor for patients with advanced gastric cancer.

The prognostic nutritional index is a predictive indicator of prognosis and postoperative complications in gastric cancer: A meta-analysis

“…On the other hand, some studies reported that postoperative complications were associated with poor prognosis in patients with GC. 3,4,33 However, herein we could not conclude that the PNI affected the prognosis of GC patients by affecting the occurrence of postoperative complications. Therefore, further studies are needed to elucidate this issue.…”

“…On the other hand, some studies reported that postoperative complications, such as anastomotic leakage, can lead to poor prognosis in patients with GC. 3,4 It is valuable to identify patients who are likely to have unfavorable postoperative outcomes. Therefore, a method for the accurate prediction of postoperative complications and prognosis is needed to guide clinical decisions and improve the survival of patients.…”

Association between tumor response and postoperative morbidity after neoadjuvant chemotherapy for gastroesophageal adenocarcinoma?

“…For both esophagectomies and gastrectomies, it has been shown that anastomotic leakage is a predictor of early recurrence and shorter survival. [26][27][28] Surgeons should therefore be well aware that non-responders have a higher risk of suffering anastomotic leakage, and should make all efforts to avoid it. Such efforts might include a more meticulous anastomotic technique, an intensified rehabilitation, a more conservative surgical approach, and intensified postoperative surveillance and supportive care in nonresponders.…”

Managing Early and Late Postoperative Complications Following Gastric Surgery

“…The duodenal stump is a relatively infrequent site of leakage after subtotal or total gastrectomy, with reported frequency rates of 2-3 % [3,14,15]. Leakage from the duodenal stump with resultant inflammation has also been reported as a negative prognostic factor for overall survival after surgery for gastric cancer [14].…”

“…Leakage from the duodenal stump with resultant inflammation has also been reported as a negative prognostic factor for overall survival after surgery for gastric cancer [14]. Management may be nonoperative with percutaneous drain placement or may require reoperation with drain placement, although further attempts at duodenal stump closure are rarely successful.…”