Negative effects of serum p,p′-DDE on sperm parameters and modification by genetic polymorphisms

M, Messaros, Bridget; Rossano, M.G.; Liu, Guanghui; Diamond, Michael P.; Friderici, Karen; Nummy-Jernigan, Katherine; Daly, Douglas C.; Puscheck, Elizabeth E.; Paneth, Nigel; Wirth, Julia J.

doi:10.1016/j.envres.2009.02.009

Cited by 37 publications

(29 citation statements)

References 35 publications

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“…This reduction may be due to genetic differences, environmental factors, or both [35]. Some studies found genetic polymorphisms which might influence semen quality after exposure to environmental pesticides, suggesting that changes in genes related to pesticide metabolism could affect susceptibility to sperm abnormalities as a result of exposure [9,36]. The results of our study are particularly interesting in light of these findings, as they could suggest the existence of subjects who are genetically predisposed and thus more sensitive to endocrine disruptors, with a higher risk of impaired semen quality and higher incidence of testicular cancer.…”

Section: Discussionmentioning

confidence: 95%

Exposure to polychlorinated biphenyls and hexachlorobenzene, semen quality and testicular cancer risk

Paoli

Giannandrea

Gallo

et al. 2015

J Endocrinol Invest

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The International Agency for Research on Cancer recently included dioxin-like polychlorinated biphenyls (PCBs) in Group 1 of known human carcinogens. Our study confirmed and identified various risk factors for testicular cancer: cryptorchidism, consumption of milk and dairy products, parents' occupation and serum concentration of hexachlorobenzene and PCBs and, for the first time, we showed the correlation between semen quality and the serum concentration of these pollutants.

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Section: Discussionmentioning

confidence: 95%

Exposure to polychlorinated biphenyls and hexachlorobenzene, semen quality and testicular cancer risk

Paoli

Giannandrea

Gallo

et al. 2015

J Endocrinol Invest

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“…The decrease in ATP content could impair spermatogenesis, and spermiogenesis in particular, causing increased levels of morphologically abnormal sperm and altered sperm chromatin integrity/condensation. Indeed several reports have shown correlations between DDT and DDE concentrations and these parameters [30][31][32].…”

Section: Discussionmentioning

confidence: 99%

Differential effects of p,p′-DDE on testis and liver mitochondria:Implications for reproductive toxicology

Mota

Cordeiro

Pereira

et al. 2011

Reproductive Toxicology

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a b s t r a c tThe release of environmental contaminants can contribute to impaired male fertility. The bioenergetics of isolated liver mitochondria have been used as a toxicological indicator, an inexpensive first line model to screen possible effects of several substances. Here we report the effects of 2,2-bis(4-chlorophenyl)-1,1-dichloro-ethylene (DDE) on the bioenergetical parameters of testicular mitochondria. A significant decrease in repolarization potential (after a phosphorylative cycle), state 3 respiration and uncoupled respiration, with a concomitant increase in lag phase was found, demonstrating a decrease in mitochondrial function. Importantly, there was also a clear increase in maximum potential in DDE-treated testis mitochondria, which was not mirrored by more commonly used liver mitochondria. Indeed, comparative studies showed that testis and liver mitochondria have strikingly different sensitivities and patterns of response to DDE, indicating that testis mitochondria should be used as a primary toxicological model for a proper evaluation of putative effects of environmental toxicants on the bioenergetics of spermatogenesis and male fertility.

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“…Of the 17 included studies, two also investigated the effect modification specific genetic polymorphisms may have on the associations between pesticide exposures and sperm parameters (Messaros et al, 2009, Perez-Herrera et al, 2008). …”

Section: Resultsmentioning

confidence: 99%

Environmental and occupational pesticide exposure and human sperm parameters: A systematic review

2013

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Of continuing concern are the associations between environmental or occupational exposures to pesticides and semen quality parameters. Prior research has indicated that there may be associations between exposure to pesticides of a variety of classes and decreased sperm health. The intent of this review was to summarize the most recent evidence related to pesticide exposures and commonly used semen quality parameters, including concentration, motility and morphology. The recent literature was searched for studies published between January, 2007 and August, 2012 that focused on environmental or occupational pesticide exposures. Included in the review are 17 studies, 15 of which reported significant associations between exposure to pesticides and semen quality indicators. Two studies also investigated the roles genetic polymorphisms may play in the strength or directions of these associations. Specific pesticides targeted for study included dichlorodiphenyltrichloroethane (DDT), hexachlorocyclohexane (HCH), and abamectin. Pyrethroids and organophosphates were analyzed as classes of pesticides rather than as individual compounds, primarily due to the limitations of exposure assessment techniques. Overall, a majority of the studies reported significant associations between pesticide exposure and sperm parameters. A decrease in sperm concentration was the most commonly reported finding among all of the pesticide classes investigated. Decreased motility was also associated with exposures to each of the pesticide classes, although these findings were less frequent across studies. An association between pesticide exposure and sperm morphology was less clear, with only two studies reporting an association. The evidence presented in this review continues to support the hypothesis that exposures to pesticides at environmentally or occupationally relevant levels may be associated with decreased sperm health. Future work in this area should focus on associations between specific pesticides or metabolic products and sperm quality parameters. Analysis of effects of varying genetic characteristics, especially in genes related to pesticide metabolism, also needs further attention.

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Negative effects of serum p,p′-DDE on sperm parameters and modification by genetic polymorphisms

Cited by 37 publications

References 35 publications

Exposure to polychlorinated biphenyls and hexachlorobenzene, semen quality and testicular cancer risk

Exposure to polychlorinated biphenyls and hexachlorobenzene, semen quality and testicular cancer risk

Differential effects of p,p′-DDE on testis and liver mitochondria:Implications for reproductive toxicology

Environmental and occupational pesticide exposure and human sperm parameters: A systematic review

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