Negative correlation between IL‐1β, IL‐12 and TNF‐γ, and cortisol levels in patients with panic disorder

Fernández-Serrano, Ana Belén; Moya-Faz, Francisco J.; Alegría, César Augusto Giner; Rodríguez, Juan Carlos Fernández

doi:10.1002/brb3.2624

Cited by 3 publications

(1 citation statement)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Quagliato and Nardi [ 123 ], in a systematic review, concluded that serum levels of the proinflammatory cytokines interleukin-6 (IL-6) and IL-1β were increased in PD patients. In a study on 41 PD patients (11 men and 30 women), in which levels of proinflammatory cytokines and cortisol were measured in saliva, it was found that levels of IL-1β, IL-12 and tumor necrosis factor-α (TNF-α) were negatively correlated with cortisol levels [ 124 ]; the authors concluded that in PD patients the inflammatory response related to the altered microbiome-gut-brain axis is associated with HPA axis reactivity and may influence the maintenance of anxiety. Although there is a paucity of information on the gut microbiota in PD, alterations in oral microbiota have been reported [ 125 ].…”

Section: Panic Disorder and Social Anxiety Disordermentioning

confidence: 99%

The Gut-Brain Axis and the Microbiome in Anxiety Disorders, Post-Traumatic Stress Disorder and Obsessive-Compulsive Disorder

MacKay

Yang

Dursun

et al. 2024

View full text Add to dashboard Cite

A large body of research supports the role of stress in several psychiatric disorders in which anxiety is a prominent symptom. Other research has indicated that the gut microbiome-immune system brain axis is involved in a large number of disorders and that this axis is affected by various stressors. The focus of the current review is on the following stress-related disorders: generalized anxiety disorder, panic disorder, social anxiety disorder, post-traumatic stress disorder and obsessive-compulsive disorder. Descriptions of systems interacting in the gut-brain axis, microbiome-derived molecules and of pro- and prebiotics are given. Preclinical and clinical studies on the relationship of the gut microbiome to the psychiatric disorders mentioned above are reviewed. Many studies support the role of the gut microbiome in the production of symptoms in these disorders and suggest the potential for pro- and prebiotics for their treatment, but there are also contradictory findings and concerns about the limitations of some of the research that has been done. Matters to be considered in future research include longer-term studies with factors such as sex of the subjects, drug use, comorbidity, ethnicity/race, environmental effects, diet, and exercise taken into account; appropriate compositions of pro- and prebiotics; the translatability of studies on animal models to clinical situations; and the effects on the gut microbiome of drugs currently used to treat these disorders. Despite these challenges, this is a very active area of research that holds promise for more effective, precision treatment of these stress.

show abstract

Section: Panic Disorder and Social Anxiety Disordermentioning

confidence: 99%

The Gut-Brain Axis and the Microbiome in Anxiety Disorders, Post-Traumatic Stress Disorder and Obsessive-Compulsive Disorder

MacKay

Yang

Dursun

et al. 2024

View full text Add to dashboard Cite

show abstract

Negative correlation between IL‐1β, IL‐12 and TNF‐γ, and cortisol levels in patients with panic disorder

et al. 2022

Self Cite

View full text Add to dashboard Cite

Introduction Chronic exposure to stress is a major risk factor in anxiety disorders (ADs) and can be accompanied by an altered microbiome–gut–brain axis and a compromised immune system. In recent years, the study of inflammatory processes in AD has gained special attention. Continued stress causes the reactivity of the hypothalamic–pituitary–adrenal (HPA) axis, the alteration of the intestinal microbiota and the consequent release of pro‐inflammatory cytokines, affecting the sensitivity to stress and the similar behavior of anxiety. Method The aim of the present study was to evaluate the interrelationships between measures of proinflammatory cytokines and cortisol in patients with panic disorder (PD). Results The main results of the correlation analysis revealed that the levels of pro‐inflammatory cytokines interleukin (IL)‐1β, IL‐12, and tumor necrosis factor gamma were negatively correlated with cortisol scores (area under the curve with respect to the ground). Conclusions These results suggest that the inflammatory response is associated with the reactivity of the HPA axis in patients with PD and may influence the maintenance of anxiety behavior.

show abstract

T cell senescence: a new perspective on immunotherapy in lung cancer

Huang,

Wang,

Fang

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

T cell senescence is an indication of T cell dysfunction. The ability of senescent T cells to respond to cognate antigens is reduced and they are in the late stage of differentiation and proliferation; therefore, they cannot recognize and eliminate tumor cells in a timely and effective manner, leading to the formation of the suppressive tumor microenvironment. Establishing methods to reverse T cell senescence is particularly important for immunotherapy. Aging exacerbates profound changes in the immune system, leading to increased susceptibility to chronic, infectious, and autoimmune diseases. Patients with malignant lung tumors have impaired immune function with a high risk of recurrence, metastasis, and mortality. Immunotherapy based on PD-1, PD-L1, CTLA-4, and other immune checkpoints is promising for treating lung malignancies. However, T cell senescence can lead to low efficacy or unsuccessful treatment results in some immunotherapies. Efficiently blocking and reversing T cell senescence is a key goal of the enhancement of tumor immunotherapy. This study discusses the characteristics, mechanism, and expression of T cell senescence in malignant lung tumors and the treatment strategies.

show abstract

Negative correlation between IL‐1β, IL‐12 and TNF‐γ, and cortisol levels in patients with panic disorder

Cited by 3 publications

References 83 publications

The Gut-Brain Axis and the Microbiome in Anxiety Disorders, Post-Traumatic Stress Disorder and Obsessive-Compulsive Disorder

The Gut-Brain Axis and the Microbiome in Anxiety Disorders, Post-Traumatic Stress Disorder and Obsessive-Compulsive Disorder

Negative correlation between IL‐1β, IL‐12 and TNF‐γ, and cortisol levels in patients with panic disorder

T cell senescence: a new perspective on immunotherapy in lung cancer

Contact Info

Product

Resources

About