Negative chronotropic effect of proton pump inhibitors on frog-heart preparation

Gautam, CS; Utreja, Amita; Goel, Divya; Sandhu, Gurpreet S.; Gogia, Nidhi

doi:10.1007/s12664-009-0052-x

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…A study evaluating animal model of frog by Gautam et al [ 28 ] , showed interesting results. They found that PPI in minimal used dose did not change heart rate, but when they increased doses twice, they noticed bradycardia.…”

Section: Discussionmentioning

confidence: 99%

Effects of ischemia and omeprazole preconditioning on functional recovery of isolated rat heart

Jeremić¹,

Petkovic²,

Srejović³

et al. 2015

Revista Brasileira De Cirurgia Cardiovascular

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ObjectiveThe aim of this study was to compare protective effects of ischemic and potential protective effects of pharmacological preconditioning with omeprazole on isolated rat heart subjected to ischemia/reperfusion.MethodsThe hearts of male Wistar albino rats were excised and perfused on a Langendorff apparatus. In control group (CG) after stabilization period, hearts were subjected to global ischemia (perfusion was totally stopped) for 20 minutes and 30 minutes of reperfusion. Hearts of group II (IPC) were submitted to ischemic preconditioning lasting 5 minutes before 20 minutes of ischemia and 30 minutes of reperfusion. In third group (OPC) hearts first underwent preconditioning lasting 5 minutes with 100μM omeprazole, and then submitted 20 minutes of ischemia and 30 minutes of reperfusion.ResultsAdministration of omeprazole before ischemia induction had protective effect on myocardium function recovery especially regarding to values of systolic left ventricular pressure and dp/dt max. Also our findings are that values of coronary flow did not change between OPC and IPC groups in last point of reperfusion.ConclusionBased on our results it seems that ischemic preconditioning could be used as first window of protection after ischemic injury especially because all investigated parameters showed continuous trend of recovery of myocardial function. On the other hand, preconditioning with omeprazole induced sudden trend of recovery with positive myocardium protection, although less effective than results obtained with ischemic preconditioning not withstand, we must consider that omeprazole may be used in many clinical circumstances where direct coronary clamping for ischemic preconditioning is not possible.

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Section: Discussionmentioning

confidence: 99%

Effects of ischemia and omeprazole preconditioning on functional recovery of isolated rat heart

Jeremić¹,

Petkovic²,

Srejović³

et al. 2015

Revista Brasileira De Cirurgia Cardiovascular

View full text Add to dashboard Cite

show abstract

“…Regarding the heart, it has been shown previously that PPIs exert a strong negative inotropic effect on isolated ventricular myocytes as well as on isolated muscle strips of healthy rabbits , atrial muscle strips of patients undergoing cardiac surgery , and ventricular muscle strips of end‐stage failing human hearts . A negative chronotropic effect of PPIs has been demonstrated in isolated rat atrium and an in vitro preparation of a beating frog heart .…”

Section: Discussionmentioning

confidence: 97%

“…In vitro experiments have demonstrated a negative chronotropic effect in an isolated frog heart preparation and rat atrium . In addition, a negative inotropic effect of pantoprazole has been found in human and rabbit ventricular myocardium as well as human atrial myocardium .…”

Section: Introductionmentioning

confidence: 97%

Negative Hemodynamic Effects of Pantoprazole at High Infusion Rates in Mice

Unsöld

Teucher

Didié

et al. 2015

Cardiovascular Therapeutics

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SUMMARYBackground: Pantoprazole has been shown to exert a negative inotropic effect in isolated myocardium. The purpose of this study was to evaluate the hemodynamic effects of pantoprazole in vivo in healthy myocardium and in the setting of heart failure. Methods and Results: Healthy mice and mice with heart failure 4 weeks after myocardial infarction induced by permanent LAD ligation were instrumented with a Millar Mikrotip conductance catheter to record pressure-volume loops. Pantoprazole was infused at rates of 3 and 10 mg/kg/min intravenously, and hemodynamic parameters were recorded. Infusion of pantoprazole at increasing rates lead to a significant decline of end systolic LV pressure by decreasing heart rate, myocardial contractility and arterial elastance. These effects were quick, beginning immediately with the infusion and usually reaching a plateau after 2 or 3 min of infusion. The effects on blood pressure and heart rate were of comparable size in healthy mice and mice with MI. However, in sham-operated mice, there was a compensatory increase in stroke volume that sufficed to maintain cardiac output at a constant level, which was missing in mice with MI. In 4 of 13 mice with MI infusion of 10 mg/kg/min pantoprazole lead to pump failure, which was lethal in 2 of these animals. Conclusion: At higher infusion rates, pantoprazole is able to induce negative hemodynamic responses. In particular, in the setting of heart failure, these effects can lead to significant impairment of cardiac function. Therefore, high infusion rates of pantoprazole should be avoided especially in heart failure patients.

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Negative chronotropic effect of proton pump inhibitors on frog-heart preparation

Cited by 2 publications

References 9 publications

Effects of ischemia and omeprazole preconditioning on functional recovery of isolated rat heart

Effects of ischemia and omeprazole preconditioning on functional recovery of isolated rat heart

Negative Hemodynamic Effects of Pantoprazole at High Infusion Rates in Mice

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