Negative associations between folate and bacterial vaginosis in the NHANES 2001 to 2004

Abstract

Background Bacterial vaginosis (BV) is one of the most common infections among women of reproductive age and accounts for 15–50% of infections globally. The role played by folate in the pathogenesis and progression of BV is poorly understood. The aim of this study was to investigate the association between serum folate, red blood cell (RBC) folate, and BV in American women. Methods 1,954 participants from the 2001-2004 National Health and Nutrition Examination Survey (NHANES) program were included in this study. Multiple logistic regression was used to analyze the association between serum folate, RBC folate, and BV, and covariates including race, age, education level, and body mass index were used to construct adjusted models. Stratified analysis was used to explore the stability of the above associations in different populations. Results In the present cross-sectional study, we found that serum folate and RBC folate were inversely associated with the risk of BV. In the fully adjusted model, the risk of BV was reduced by 35% (OR=0.65, 95% CI: 0.51~0.83, p=0.0007) in the highest serum folate group and 32% (OR=0.68, 95% CI: 0.53~0.87, p=0.0023) in the highest RBC folate group compared to the lowest group. Conclusions The results of this study indicated that serum folate and RBC folate were inversely associated with the risk of BV folate supplementation may play an important role in the prevention and management of BV.

Biomarker Identification for Preterm Birth Susceptibility: Vaginal Microbiome Meta‐Analysis Using Systems Biology and Machine Learning Approaches

“…For example, lipopolysaccharide (LPS) is a microbiota endotoxin, which acts on maternal Toll like receptors, activates the inflammatory cascades and induces PTB [10]. Folates play a key role in maternal health and its levels are associated with bacterial vaginosis, a known cause of PTB [65]. Similarly, a study has shown that plasma retinol levels are significantly reduced in PTB, while retinal palmitate, all-transretinal, and 13-cis-retinoic acid (13cis-RA) are elevated [66].…”