Negative Association between Acrylamide Exposure and Metabolic Syndrome Markers in Adult Population

Hung, Chun-Chi; Cheng, Yung-Wen; Chen, Wei‐Liang; Fang, Wen‐Hui

doi:10.3390/ijerph182211949

Cited by 9 publications

(10 citation statements)

References 41 publications

(51 reference statements)

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“…The first is far more common in humans and is based on the conjugation of AA with glutathione (GSH), which results in the formation of metabolites excreted by the urine [ 20 ]. The second metabolic pathway is the oxidative transformation of AA with cytochrome P450 2E1 (CYP2E1; EC 1.14.13) to epoxide 2,3-epoxypropane amide (glycidamide—GA), which is proven to have genotoxic properties [ 22 ]. Approximately 15% of internalized AA is epoxidated to GA, which, like AA, has electrophilic reactivity [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Acrylamide and Potential Risk of Diabetes Mellitus: Effects on Human Population, Glucose Metabolism and Beta-Cell Toxicity

Filipović

Karan

Ivelja

et al. 2022

IJMS

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Diabetes mellitus is a frequent endocrine disorder characterized by hyperglycemia. Acrylamide (AA) is food contaminant formed during the high-temperature processing of food rich in carbohydrates and low in proteins. Recent human epidemiological studies have shown a potential association between AA exposure and the prevalence of diabetes in the general population. In male rats, AA treatment promoted pancreatic islet remodeling, which was determined by alpha-cell expansion and beta-cell reduction, while in female rats AA caused hyperglycemia and histopathological changes in pancreatic islets. In vitro and in vivo rodent model systems have revealed that AA induces oxidative stress in beta cells and that AA impairs glucose metabolism and the insulin signaling pathway. Animal studies have shown that diabetic rodents are more sensitive to acrylamide and that AA aggravates the diabetic state. In this review, we provide an overview of human epidemiological studies that examined the relation between AA exposure and glucose disorders. In addition, the effects of AA treatment on pancreatic islet structure, beta-cell function and glucose metabolism in animal models are comprehensively analyzed with an emphasis on sex-related responses. Furthermore, oxidative stress as a putative mechanism of AA-induced toxicity in beta cells is explored. Finally, we discuss the effects of AA on diabetics in a rodent model system.

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Section: Introductionmentioning

confidence: 99%

Acrylamide and Potential Risk of Diabetes Mellitus: Effects on Human Population, Glucose Metabolism and Beta-Cell Toxicity

Filipović

Karan

Ivelja

et al. 2022

IJMS

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“…In histopathological observation, they clearly depicted that AA exposure induced neuronal degeneration and cerebral atrophy with the proliferation of microglia. A case study from Sweden has reported that tunnel workers are affected by neurological disorders as they are exposed to an intensive grouting agent (AA with N-methylol AA), which is used as waterproof leak in a tunnel wall (Hung et al, 2021). In another study by Chen et al (2021), a significant damage in the nervous system may be because AA toxicity leads to the inhibition of neuroblastoma and glioblastoma differentiation.…”

Section: Neurotoxicmentioning

confidence: 99%

Possible metabolic effect of acrylamide on biological system

Gupta,

Singh,

Soni

et al. 2023

Food Safety and Health

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Acrylamide (AA) is a chemical agent mostly used in the manufacture of polymers and copolymers. Recently, it has gained attention because of its production in food items prepared at high‐temperature (>120°C) processes, such as frying, toasting, cooking, roasting or baking of high carbohydrate food items. As per the higher exposure of AA, appropriate identification of its toxic effect is necessary. Hepatotoxicity, nephrotoxicity, neurotoxicity, reproductive toxicity, and immunotoxicity of AA have been observed in several studies. AA could also be considered as endocrine‐disrupting chemicals and its exposure leads to many hormonal abnormalities. Nearly one in every four couples of a developing nation suffers from infertility, and AA exposure may be one of the reasons. AA is proven as a potent reproductive toxicant, affecting both male and female reproductive organ functioning. This review summarizes research conducted on the toxicity of AA in various organs.

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“…Table 2 shows data from human epidemiological studies on acrylamide exposure with obesity-related biomarkers. 22 , 140 , 142 , 143 , 160–162 The exposure levels of humans to environmental chemicals are generally estimated by biomonitoring of these chemical’s essential compounds or metabolites in human urine or blood as exposure biomarkers. 163 DNA adducts of acrylamide might be used as biomarkers for monitoring chronic internal exposure to acrylamide.…”

Section: Acrylamide As a Controversial Obesogenic Compoundmentioning

confidence: 99%

From a toxin to an obesogen: a review of potential obesogenic roles of acrylamide with a mechanistic approach

Büyükdere

Akyol

2023

Nutrition Reviews

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Obesity and obesity-related disorders such as cancer, type 2 diabetes, and fatty liver have become a global health problem. It is well known that the primary cause of obesity is positive energy balance. In addition, obesity is the consequence of complex gene and environment interactions that result in excess calorie intake being stored as fat. However, it has been revealed that there are other factors contributing to the worsening of obesity. The presence of nontraditional risk factors, such as environmental endocrine-disrupting chemicals, has recently been associated with obesity and comorbidities caused by obesity. The aim of this review was to examine the evidence and potential mechanisms for acrylamide having endocrine-disrupting properties contributing to obesity and obesity-related comorbidities. Recent studies have suggested that exposure to environmental endocrine-disrupting obesogens may be a risk factor contributing to the current obesity epidemic, and that one of these obesogens is acrylamide, an environmental and industrial compound produced by food processing, particularly the processing of foods such as potato chips, and coffee. In addition to the known harmful effects of acrylamide in humans and experimental animals, such as neurotoxicity, genotoxicity, and carcinogenicity, acrylamide also has an obesogenic effect. It has been shown in the literature to a limited extent that acrylamide may disrupt energy metabolism, lipid metabolism, adipogenesis, adipocyte differentiation, and various signaling pathways, and may exacerbate the disturbances in metabolic and biochemical parameters observed as a result of obesity. Acrylamide exerts its main potential obesogenic effects through body weight increase, worsening of the levels of obesity-related blood biomarkers, and induction of adipocyte differentiation and adipogenesis. Additional mechanisms may be discovered. Further experimental studies and prospective cohorts are needed, both to supplement existing knowledge about acrylamide and its effects, and to clarify its established relationship with obesity and its comorbidities.

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Negative Association between Acrylamide Exposure and Metabolic Syndrome Markers in Adult Population

Cited by 9 publications

References 41 publications

Acrylamide and Potential Risk of Diabetes Mellitus: Effects on Human Population, Glucose Metabolism and Beta-Cell Toxicity

Acrylamide and Potential Risk of Diabetes Mellitus: Effects on Human Population, Glucose Metabolism and Beta-Cell Toxicity

Possible metabolic effect of acrylamide on biological system

From a toxin to an obesogen: a review of potential obesogenic roles of acrylamide with a mechanistic approach

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