Negative affective responses to a speech task predict changes in interleukin (IL)-6☆

Carroll, Judith; Low, Carissa A.; Prather, Aric A.; Cohen, Sheldon; Fury, Jacqueline M.; Ross, Diana; Marsland, Anna L.

doi:10.1016/j.bbi.2010.09.024

Cited by 115 publications

(106 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our patients were homogeneous in age and had not received any previous treatment. This is quite important because it is reported in the literature that sE-cad and/or IL-6 values can be affected by age, treatment or circadian rhythm (25)(26)(27), even if there is no agreement among all authors particularly regarding sE-cad (25,28). Moreover, as described in Patients and methods, blood samples were taken at least three days after i.v.…”

Section: Discussionmentioning

confidence: 99%

Soluble E-cadherin and IL-6 serum levels in patients affected by prostate cancer before and after prostatectomy

Sica¹

2012

Oncol Rep

View full text Add to dashboard Cite

Abstract. Prostate specific antigen (PSA) is still the best available tumour marker in prostate cancer (PCa), but presents some limits. Therefore, there is a need for novel markers in the detection and management of PCa. The 80-kDa soluble form of E-cadherin (sE-cad) and the cytokine IL-6 are being discussed as supplemental serum markers for PCa. In this study, sE-cad and IL-6 serum levels were determined in patients with pathological localized or locally advanced PCa without any previous treatment. These patients underwent radical retropubic prostatectomy (RRP) in accordance with the EAU Guidelines on Prostate Cancer. The molecules were determined via immunoenzymatic assays in samples collected before and after surgery. Statistical analysis was performed by Student's t-test and Pearson's correlation test. sE-cad levels were 6.0±2.7 and 4.6±2.3 µg/ml, before and after RRP, respectively. A highly statistically significant decrease in sE-cad concentrations after RRP was observed (P<0.0001), in 50/61 patients (82%). sE-cad levels before and after surgery were correlated (Pearson's correlation coefficient, r=0.6993, P<0.0001). sE-cad values detected after surgery were higher in patients with PSA levels >10 ng/ml (P<0.05). sE-cad levels before RRP were significantly higher in patients with G3 tumours compared to those with G2 tumours (P<0.02). Finally, sE-cad concentrations both before and after surgery were higher in tumours with Gleason score =7 compared to those with Gleason score <7 (P<0.002 and P<0.05, respectively). Preliminary data from 20 patients indicated a statistically significant increase in IL-6 levels after RRP (11.2 vs. 7.2 pg/ml, P<0.001). This is the first study on the reduction in sE-cad levels after RRP in PCa patients. Moreover, it shows that preoperative sE-cad concentrations are higher in patients with less differentiated PCa. Promising findings of this pilot study may lead to investigation of sE-cad in a larger study with follow-up.

show abstract

Section: Discussionmentioning

confidence: 99%

Soluble E-cadherin and IL-6 serum levels in patients affected by prostate cancer before and after prostatectomy

Sica¹

2012

Oncol Rep

View full text Add to dashboard Cite

show abstract

“…As not all studies addressing this relationship have reported a positive association between increased inflammation and these anxiety disorders, the importance of factors such as population assessed (community vs clinical), clinician-administered vs self-reported measures of anxiety disorder diagnosis, sociodemographic factors of individuals studied (eg, sex), and co-morbid mental and physical health problems must be considered. Looking more generally at anxiety and associations with proinflammatory markers in non-patient populations, researchers have found evidence that anxiety is related to higher concentrations of CRP and peripheral cytokines (Brennan et al, 2009;O'Donovan et al, 2010;Pitsavos et al, 2006) and predicts increased inflammatory response following acute stress (Carroll et al, 2011;Moons et al, 2010;Moons and Shields, 2015), demonstrating that anxiety and fear even at non-clinical levels impacts the immune response in important ways. There remains a great deal to understand about the association between anxiety disorders and inflammation, and more research is needed before any clear conclusions can be made.…”

Section: Fear-and Anxiety-based Disorders and Inflammationmentioning

confidence: 99%

Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond

Michopoulos

Powers

Gillespie

et al. 2016

Neuropsychopharmacol

525

376

View full text Add to dashboard Cite

The study of inflammation in fear-and anxiety-based disorders has gained interest as growing literature indicates that proinflammatory markers can directly modulate affective behavior. Indeed, heightened concentrations of inflammatory signals, including cytokines and C-reactive protein, have been described in posttraumatic stress disorder (PTSD), generalized anxiety disorder (GAD), panic disorder (PD), and phobias (agoraphobia, social phobia, etc.). However, not all reports indicate a positive association between inflammation and fear-and anxiety-based symptoms, suggesting that other factors are important in future assessments of inflammation's role in the maintenance of these disorders (ie, sex, co-morbid conditions, types of trauma exposure, and behavioral sources of inflammation). The most parsimonious explanation of increased inflammation in PTSD, GAD, PD, and phobias is via the activation of the stress response and central and peripheral immune cells to release cytokines. Dysregulation of the stress axis in the face of increased sympathetic tone and decreased parasympathetic activity characteristic of anxiety disorders could further augment inflammation and contribute to increased symptoms by having direct effects on brain regions critical for the regulation of fear and anxiety (such as the prefrontal cortex, insula, amygdala, and hippocampus). Taken together, the available data suggest that targeting inflammation may serve as a potential therapeutic target for treating these fear-and anxiety-based disorders in the future. However, the field must continue to characterize the specific role pro-inflammatory signaling in the maintenance of these unique psychiatric conditions.

show abstract

“…should remain low to avoid emotional and systemic disturbances (MEYER; DA SILVA, 1999;CARROLL et al, 2011;DE ALMEIDA et al, 2013;GOMES DA SILVA et al, 2013). Sheltered dogs present behavior pattern similar to that of owned dogs, although interaction with the environment and other dogs were greater.…”

Section: Task Different Authors Consider Different Cortisol Values Amentioning

confidence: 99%

“…It has been reported that cortisol influences learning in dogs under stress (HAUBENHOFER; KIRCHENGAST, 2007;HAVERBEKE et al, 2008). IL6 participates in the first general inflammatory response to any injury (BLACK, 2002), including psychic and immediate source as acute stress (HEINRICH et al, 2003;NAS et al, 2011;IZAWA et al, 2013a), and can interfere with cognitive performance, since it stimulates aggression when acting in the limbic system and amygdala (ARHANT et al, 2010;CARROLL et al, 2011;DE ALMEIDA et al, 2013). However, we should question if these newly housed animals are not even more stressed during training.…”

Section: Introductionmentioning

confidence: 99%

“…Two factors are related to stress: interleukin 6 (IL6) to acute stress (HEINRICH et al, 2003;KUNZ-EBRECHT et al, 2003;CARROLL et al, 2011;CAMPISI et al, 2012;IZAWA et al, 2013b), and cortisol to chronic stress (BEERDA et al, 1997;BEERDA et al, 1999b;BEERDA et al, 2000;ACCORSI, 2008;AGUILERA, 2011). It has been reported that cortisol influences learning in dogs under stress (HAUBENHOFER; KIRCHENGAST, 2007;HAVERBEKE et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Correlação dos parâmetros endócrinos e comportamentais em cadelas abandonadas em programa de ressocialização

Lesnau¹

View full text Add to dashboard Cite

Á DEUS, que no silêncio das madrugadas, permitiu-me conhecê-Lo, entendê-Lo e me ensinou a conversar com Ele. Volto para casa com minha fé descoberta e com uma experiência íntima muito forte estabelecendo esta aliança. Graças dou! À minha mãe Otilia Wisniewski Lesnau pelas vezes em que cruzou o Brasil para socorrer minha família na minha ausência e o apoio que sempre ofereceu. A todos vocês, muito obrigado! Epígrafe "Dizem que a oportunidade é uma deusa que tem cabelo na testa, portanto você tem de apanhá-la quando ela vem de frente porque depois que ela passa, a única coisa a fazer é se lamentar". The mechanism of stress is already known and can be divided in two stages: acute stress, which releases thermogenic factors and inflammatory -mediated interleukin 6 (IL6) and chronic stress, which suppresses the inflammatory response and is mediated by the presence of cortisol. When stray dogs are housed in shelters, they undergo a period of adaptation; however, until now there is not a ressocialization program at the governmental level aiming to improve their welfare along with their new owners. The ressocialization program beginning when dogs arrive to the shelter and the correlation of dogs´ behavior with physiological and endocrine parameters related to stress have not yet been described , which raises the hypothesis that it can decrease the traumatic impact of abandonment. Twenty seven healthy bitches were divided into 3 groups: with owners, abandoned not trained and abandoned trained.The trained and abandoned dogs were later adopted. The training lasted 15 min / day for 21 days. The behavioral assessment (ethogram and ethotest) was performed every 7 days and physiological parameters assessment (heart rate, respiratory rate, blood oxygenation rate, pulse) as well as saliva collection, daily. After the adoption, the bitches were evaluated for 7 additional days. Data were analyzed by ANOVA, after testing the results for normality. The correlation between parameters was analyzed using the Pearson correlation test. Values were considered different at p < 0.05. The most surprisingly result was the maintenance of low levels of IL6 in trained dogs after neutering, whereas the other two groups showed a significant increase of IL6. The consequences of training were evident in ethograms after adoption: there was an improvement of the interaction of dogs with the new family, attitudes of playing were more numerous, and dogs showed a greater receptivity to the new owners. The tail wagging, as communication behavior, appeared much more frequently in trained dogs after adoption. Abandoned dogs after adoption manifested more idleness, discouragement and depression behaviors and reduced alertness.These results suggest that the training reassures bitches in the stressful shelter environment, improves their physiological parameters, controls fear behaviors making them more able to adapt to the new environment after adoption. There were no differences in cortisol among the groups (p > 0.05). However, IL-6 concentration was lower in ...

show abstract

Negative affective responses to a speech task predict changes in interleukin (IL)-6☆

Cited by 115 publications

References 38 publications

Soluble E-cadherin and IL-6 serum levels in patients affected by prostate cancer before and after prostatectomy

Soluble E-cadherin and IL-6 serum levels in patients affected by prostate cancer before and after prostatectomy

Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond

Correlação dos parâmetros endócrinos e comportamentais em cadelas abandonadas em programa de ressocialização

Contact Info

Product

Resources

About