Neem: a magical herb in endodontics

Singh, Harpreet; Kaur, Mandeep; Dhillon, Jaidev Singh; Batra, Munish; Khurana, Jyotsna

doi:10.20517/2573-0002.2016.10

Cited by 10 publications

(7 citation statements)

References 6 publications

(6 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neem (Azadirachta indica) has gained research interest in endodontics worldwide due to its wide range of medicinal properties as antibacterial, antifungal, antipyretic, analgesic, antioxidant and anti‐inflammatory (Singh et al . 2017, Islas et al . 2020).…”

Section: Discussionmentioning

confidence: 99%

Effect of Neem (Azadirachta indica) versus 2.5% sodium hypochlorite as root canal irrigants on the intensity of post‐operative pain and the amount of endotoxins in mandibular molars with necrotic pulps: a randomized controlled trial

et al. 2021

View full text Add to dashboard Cite

Aim To assess the effect of Neem versus 2.5% NaOCl as root canal irrigants on the intensity of post‐operative pain and amount of endotoxins following root canal treatment of mandibular molars with necrotic pulps. Methodology This parallel, prospective, double‐blinded, randomized controlled trial with allocation ratio 1:1 was conducted in the out‐patient clinic of the Endodontic Department, Faculty of Dentistry, Cairo University, Egypt. Fifty healthy patients with mandibular molars with necrotic pulps were randomly assigned into two equal groups using computer software. In the intervention group, root canals were irrigated using Neem; whilst 2.5% NaOCl was used in the control group. A standard root canal treatment was performed in two visits using ProTaper Next rotary files, with no intracanal medication. Pain intensity was assessed using a numerical rating scale (NRS) 6, 12, 24 and 48 h following instrumentation and canal filling. Endotoxin samples were collected using three paper points before and after canal instrumentation and a sandwich ELISA method was used to quantify the level of endotoxins. Demographic, baseline, and outcome data were collected and analysed using chi‐square tests (for the comparisons of categorical variables), Mann–Whitney tests (for non‐normally distributed variables) and Student’s t tests (for normally distributed variables), A P‐value < 0.05 was considered to be statistically significant. Results The mean pain scores within the two groups decreased continually over time. The mean pain scores in the Neem group were lower than those in the 2.5% NaOCl group at 6, 12, 24 and 48 h following instrumentation and canal filling with no significant difference between them except at 24 h following instrumentation (P = 0.012). Both irrigants significantly reduced endotoxin levels compared to the pre‐instrumentation samples (P < 0.001) by 8% for the NaOCL group and 18% for the Neem group. Conclusion Neem and 2.5% NaOCl were not significantly different in terms of reducing the intensity of post‐operative pain during all follow‐up periods except at 24 h following instrumentation where Neem was associated with lower pain intensity. Both irrigants significantly reduced endotoxin levels but were not effective in eliminating endotoxins completely from root canals of mandibular molars with necrotic pulps.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Neem (Azadirachta indica) versus 2.5% sodium hypochlorite as root canal irrigants on the intensity of post‐operative pain and the amount of endotoxins in mandibular molars with necrotic pulps: a randomized controlled trial

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Recently, the use of neem as an endodontic irrigant was proven to be helpful due to its excellent antioxidant effects, in addition to the fact that it is highly biocompatible, with no risk of tissue toxicity during use. It has been proven that neem is biocompatible with the human periodontal ligament fibroblasts, and this is an essential factor contributing to its clinical application in endodontics (37).…”

Section: Discussionmentioning

confidence: 99%

In vitro assessment of the antifungal effects of neem powder added to polymethyl methacrylate denture base material

et al. 2019

View full text Add to dashboard Cite

BackgroundDenture with antimicrobial activities is desirable to prevent Candida albican adhesion subsequently decreasing the susceptibility of denture stomatitis incidence. Azadirachta Indica, commonly known as Neem powder has antimicrobial effect but the effect of its addition to acrylic denture base on C. albicans adhesion has not been investigated. The aim of this study was determine whether adding neem powder to acrylic denture base materials could reduce Candida albicansadhesion.Material and MethodsOne hundred and twenty acrylic resin denture specimens were fabricated and divided into heat-polymerized (n=60) and auto-polymerized (n=60) groups. Each group was further divided into 6 groups (n=10) based on the neem concentration: 0, 0.5, 1, 1.5, 2 and 2.5 wt% of the polymer. After polymerization, the specimens were polished, stored in distilled water, sonicated, sterilized, submerged in artificial saliva containing C. albicans, and finally, placed in an incubator at 37°C. Slide counting and direct culture methods were used to assess the antifungal effects of the neem addition. An analysis of variance and post hoc Tukey’s test were performed for the data analysis (p≤0.05 was statistically significant).ResultsBased on the results, the neem addition significantly decreased the C. albicans count when compared to the control group (p≤0.05). Moreover, the count decreased as the neem concentration increased (lowest count with 2.5 wt%).ConclusionsThe results suggest that adding neem powder to acrylic resin denture base materials reduces the adhesion of C. albicans; therefore, the incorporation of neem could be a possible denture stomatitis prevention method. Key words:Denture stomatitis, Candida albicans, Azadirachta indica, neem powder, denture base.

show abstract

“…They concluded in their study that the neem leaf extract showed the highest zone of inhibition against E. faecalis and C. albicans. 21 Green tea extracts (GTEs) contain catechin, which is one of the polyphenols from green tea. It has been reported that GTEs have remarkable anti-inflammatory, antioxidant and anti-cariogenic effects in a number of animal tumors, cell culture system, and epidemiological studies.…”

Section: Discussion:-mentioning

confidence: 99%

Comparative Evaluation of Antimicrobial Efficacy of Sodium Hypochlorite, Chlorhexidine, Neem and Green Tea Against E. Faecalis - An in Vitro Study.

Shrigondekar¹,

ijar²,

Pawar³

et al. 2019

IJAR

View full text Add to dashboard Cite

To check the antimicrobial efficacy of sodium hypochlorite (NaOCl), chlorhexidine (CHX), neem and green tea against E. faecalis. Materials and Methods: The irrigants were divided into four groups, Group I-NaOCl, Group II-CHX, Group III-Neem, Group IV-Green tea. Agar well diffusion test was used to study the antimicrobial efficacy against E. faecalis. The plate was incubated at 37°C for 24hrs in an incubator. The zone of inhibition was recorded, tabulated, and analyzed statistically using analysis of variance. Results: All four irrigants showed well-defined and comparable zones of inhibition around their respective wells. There was significant difference between zone diameters of CHX, neem, and NaOCl against E. faecalis(p < 0.05). Conclusion: From the present study, it can be concluded that neem leaf extract shows comparable zones of inhibition with that of chlorhexidine and sodium hypochlorite.

show abstract

Neem: a magical herb in endodontics

Cited by 10 publications

References 6 publications

Effect of Neem (Azadirachta indica) versus 2.5% sodium hypochlorite as root canal irrigants on the intensity of post‐operative pain and the amount of endotoxins in mandibular molars with necrotic pulps: a randomized controlled trial

Effect of Neem (Azadirachta indica) versus 2.5% sodium hypochlorite as root canal irrigants on the intensity of post‐operative pain and the amount of endotoxins in mandibular molars with necrotic pulps: a randomized controlled trial

In vitro assessment of the antifungal effects of neem powder added to polymethyl methacrylate denture base material

Comparative Evaluation of Antimicrobial Efficacy of Sodium Hypochlorite, Chlorhexidine, Neem and Green Tea Against E. Faecalis - An in Vitro Study.

Contact Info

Product

Resources

About