Needle-Free Jet Injectors’ Geometry Design and Drug Diffusion Process Analysis

Abstract

In order to study the injection and diffusion process of the drug in the subcutaneous tissue of a needle-free jet injectors (NFJIs) in detail and understand the influence of different nozzle geometry on the diffusion process of the drug, in this paper, numerical simulations were performed to study the diffusion process of the drug in the subcutaneous tissue of NFJIs with cylindrical nozzle. On this basis, the differences of the drug diffusion process with different nozzle geometries were analyzed. The results show that the drug diffused in the shape of ellipsoid in the subcutaneous tissue. The penetration of the drug into the subcutaneous tissue is deeper under the condition of conical nozzle and conical cylindrical nozzle at the same time. However, it takes longer to spread to the interface between skin and subcutaneous tissue in reverse.

High-Pressure Delivery of Oncolytic Viruses via Needle-Free Injection Preserves Therapeutic Activity

“…Other oncolytic viruses with limited therapeutic efficacy due to poor viral spread, and additional hard-to-treat cancer models, could ultimately exhibit elevated benefits from administration by NFI. One potential improvement could be achieved via altering the nozzle geometry to optimize diffusion of OV-containing liquid inside solid tumour [40]. In addition, the injection volume and density of OV-containing vehicle could also be modified to adjust the penetration and diffusion of viruses inside tumour [41].…”