Nectrianolins A, B, and C, new metabolites produced by endophytic fungus Nectria pseudotrichia 120-1NP

Ariefta, Nanang Rudianto; Kristiana, Priska; Nurjanto, Handojo Hadi; Momma, Hiroyuki; Kwon, Eunsang; Ashitani, Tatsuya; Tawaraya, Keitaro; Murayama, Tetsuya; Koseki, Takuya; Furuno, Hiroshi; Usukhbayar, Narandulam; Kimura, Ken; Shiono, Yoshihito

doi:10.1016/j.tetlet.2017.09.032

Cited by 15 publications

(9 citation statements)

References 22 publications

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“…The structures of the sesquiterpenoids isolated from Clonostachys fungi are shown in Figure 10 . Nectrianolin C ( 174 ) from Nectria pseudotrichia 120-1NP exhibited cytotoxic activity against HL60 and HeLa cells [ 73 ].…”

Section: Terpenoids and Their Biological Activitiesmentioning

confidence: 99%

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Metabolites from Clonostachys Fungi and Their Biological Activities

Han

Zhang

et al. 2020

JoF

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Clonostachys (teleomorph: Bionectria) fungi are well known to produce a variety of secondary metabolites with various biological activities to show their pharmaceutical and agrochemical applications. Up to now, at least 229 secondary metabolites, mainly including 84 nitrogen-containing metabolites, 85 polyketides, 40 terpenoids, and 20 other metabolites, have been reported. Many of these compounds exhibit biological activities, such as cytotoxic, antimicrobial, antileishmanial, antimalarial activities. This mini-review aims to summarize the diversity of the secondary metabolites as well as their occurrences in Clonostachys fungi and biological activities.

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Section: Terpenoids and Their Biological Activitiesmentioning

confidence: 99%

“…Both nectrianolins A ( 199 ) and B ( 200 ) were sesquiterpene-epoxyclohexenone conjugates isolated from Nectria pseudotrichia 120-1NP [ 73 ].…”

Section: Terpenoids and Their Biological Activitiesmentioning

confidence: 99%

Metabolites from Clonostachys Fungi and Their Biological Activities

Han

Zhang

et al. 2020

JoF

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“…Two new sesquiterpene-epoxycyclohexenone conjugates, nectrianolins A 11 ( Figure 2 ) and nectrianolins B 12 ( Figure 2 ), together with a sesquiterpene, nectrianolin C 13 ( Figure 2 ), were isolated from the brown rice culture of Nectria pseudotrichia 120-1NP, an endophytic fungus isolated from Gliricidia sepium . It is of particular interest that 11 and 12 have a rearranged monocyclofarnesyl skeleton (which is uncommon to sesquiterpene-epoxycyclohexane conjugates) instead of a bicyclofarnesyl skeleton which is present in macrophorins, neomacrophorins, myrothecols, and craterellins [ 13 ]. It was found that endophytic Nigrospora oryzae stimulated the production of a new tremulane sesquiterpene nigrosirpexin A 14 ( Figure 2 ) from Irpex lacteus [ 14 ].…”

Section: New Metabolites Isolated From Plant Endophytesmentioning

confidence: 99%

“…Compounds 11 , 12 , and 13 exhibited cytotoxic activity against the HL60 cell line with IC 50 values of 1.7 µM, 1.5 µM and 10.1 µM, respectively. Additionally, compounds 11 , 12 , and 13 exhibited cytotoxicity against the HeLa cell line with IC 50 values of 34.7 µM, 16.6 µM and 52.1 µM, respectively [ 13 ].…”

Section: Biological Activitymentioning

confidence: 99%

Biological Activities of Some New Secondary Metabolites Isolated from Endophytic Fungi: A Review Study

Zheng

Zhang

et al. 2021

IJMS

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Secondary metabolites isolated from plant endophytic fungi have been getting more and more attention. Some secondary metabolites exhibit high biological activities, hence, they have potential to be used for promising lead compounds in drug discovery. In this review, a total of 134 journal articles (from 2017 to 2019) were reviewed and the chemical structures of 449 new metabolites, including polyketides, terpenoids, steroids and so on, were summarized. Besides, various biological activities and structure-activity relationship of some compounds were aslo described.

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“…10,[13][14][15][16][17][18] While Nectria pseudotrichia, usually considered as a plant pathogen, has been reported to produce naphthoquinones, isocoumarins, and terpenoids. [19][20][21] During our continuous search for new cytotoxic metabolites from the plant endophytic fungi, [22][23][24][25][26][27][28][29] a strain of Nectria pseudotrichia, isolated from the twigs of an identied tree on Tiantangzhai Mountain, Anhui, People's Republic of China, was grown in a solid-substrate fermentation culture. An ethyl acetate (EtOAc) extract of the culture showed cytotoxic effects towards a small panel of four human tumor cell lines.…”

Section: Introductionmentioning

confidence: 99%