Necrotizing Primary Carcinoma of the Right Adrenal Causing Fever “Of Unknown Origin” in a 71‐year‐old Male: Clinico‐pathologic Study

Ansari, Farzana; Shafer, Rex B.

doi:10.1111/j.1532-5415.1971.tb05377.x

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…It is almost always found in patients who have nonfunc tioning endocrinal tumors and in most cases it is a sign of advanced stage disease. Only in 8 cases was pro longed fever mentioned [1,2,15,17,18] as the first sign of adrenal carcinoma. To this we add 4 more patients.…”

Section: Commentsmentioning

confidence: 99%

Prolonged Fever as a Presenting Symptom in Adrenal Tumors

Klausner¹,

Nakash²,

Inbar³

et al. 1988

Oncology

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Four patients with adrenal tumors in whom prolonged fever was the foremost symptom are presented. Two of the patients had nonfunctional adrenocortical carcinoma, one had a pheochromocytoma without adrenergic hyperactivity, and in the fourth, an aldosteronoma was found. Only in 1 case was the tumor (pheochromocytoma) resectable and this patient became afebrile post surgery. A review of the literature revealed that fever is encountered in 6 10% of cases with adrenal tumors, sometimes as the first manifestation of disease. However, a survey of the large series of fever of unknown origin revealed no mention of adrenal tumors in that group of solid tumors which many cause prolonged fever.

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Section: Commentsmentioning

confidence: 99%

Prolonged Fever as a Presenting Symptom in Adrenal Tumors

Klausner¹,

Nakash²,

Inbar³

et al. 1988

Oncology

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The clinical and pathologic featurfs of “non-hormonal” adrenocortical tumors.Report of twenty new cases and review of the literature

Lewinsky

Grigor

Symingtonw

et al. 1974

Cancer

115

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The clinicopathologic features of 178 patients with “non‐hormonal” or “nonfunctioning” adrenocortical tumors are presented. Such tumors usually affect patients in the 5th, 6th, and 7th decades and occur in males twice as often as females. The prognosis is poor, most patients succumbing during the 1st year after diagnosis. The most helpful radiographic diagnostic test is the intravenous pyelogram, although arteriography and pre‐sacral air insuffiation may also aid in the diagnosis. Lymphangiography was found to be of value in assessing the lymph nodes during treatment and at subsequent followup examination. No reliable, definite indication of the functional or metastatic potential of these tumors can be made from histopathologic examination; all should be viewed as malignant. The tumors are capable of forming precursor steroids without hormonal activity. Hence they are not in fact “non‐functioning.” Their treatment should be primarily surgical, but postoperative radiotherapy should be administered if there is residual tumor. All chemotherapeutic agents are relatively ineffective but some form of combination chemotherapy may be beneficial.

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Nonfunctioning Tumors of the Adrenal Gland

Anderson

1977

Urologic Clinics of North America

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Necrotizing Primary Carcinoma of the Right Adrenal Causing Fever “Of Unknown Origin” in a 71‐year‐old Male: Clinico‐pathologic Study

Cited by 3 publications

References 3 publications

Prolonged Fever as a Presenting Symptom in Adrenal Tumors

Prolonged Fever as a Presenting Symptom in Adrenal Tumors

The clinical and pathologic featurfs of “non-hormonal” adrenocortical tumors.Report of twenty new cases and review of the literature

Nonfunctioning Tumors of the Adrenal Gland

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