Prolonged Fever as a Presenting Symptom in Adrenal Tumors

Abstract

Four patients with adrenal tumors in whom prolonged fever was the foremost symptom are presented. Two of the patients had nonfunctional adrenocortical carcinoma, one had a pheochromocytoma without adrenergic hyperactivity, and in the fourth, an aldosteronoma was found. Only in 1 case was the tumor (pheochromocytoma) resectable and this patient became afebrile post surgery. A review of the literature revealed that fever is encountered in 6 10% of cases with adrenal tumors, sometimes as the first manifestation of disease. However, a survey of the large series of fever of unknown origin revealed no mention of adrenal tumors in that group of solid tumors which many cause prolonged fever.

Large Nonfunctional Adreno Cortical Carcinoma Masquerading as Renal Cell Carcinoma: A Case Report With Review of Literatures

“…4 Klausner et al reviewed the literature and found that fever is encountered in 6-10% of cases with adrenal tumors sometimes as first manifestation of disease. 5 Flammingo et al reported a case of large nonfunctioning adrenal cortical carcinoma with a 24x 18 cm mass. 6 The patient had pre-operative fine needle biopsy suggestive of RCC without any clinical sign of adrenal carcinoma.…”

Giant non-functioning adrenocortical carcinoma: A rare childhood tumor

“…[4,5] Adrenocortical tumors are associated with fever for unknown reasons, as seen in our case. [7] Primary adrenocortical tumors are large tumors usually measuring more than 5 cm at presentation. The larger the tumor, more is the chance of it being malignant.…”

Feocromocitoma: punción y drenaje percutáneo precirugía en un caso que se presentó como absceso retroperitoneal

“…sumado a la terapia antimicrobiana, que permitió posponer la cirugía definitiva, dando tiempo a la recuperación nutricional suficiente para enfrentar una intervención quirúrgica compleja en condiciones de razonable seguridad. Finalmente, otros tumores adrenales, en especial el carcinoma suprarrenal, pueden también expresarse con fiebre 14 . El uso creciente del TAC y de la resonancia nuclear magnética ha hecho del hallazgo incidental de un tumor suprarrenal una situación más frecuente, llevando a que 10% de los diagnósticos En nuestro caso, pese a que se solicitó precozmente el estudio de catecolaminas urinarias, su evolución inicial fue alejando nuestra sospecha clínica de un feocromocitoma y apremiados por su cuadro séptico, ya habíamos sometido a la paciente a una punción percutánea y a un drenaje quirúrgico de su tumor abscedado, cuando recibimos la confirmación diagnóstica bioquímica.…”