Necrotizing Pancreatitis Associated With Severe Preeclampsia

Swank, Morgan; Nageotte, Michael P.; Hatfield, Tamera

doi:10.1097/aog.0b013e31824fc617

Cited by 16 publications

(11 citation statements)

References 4 publications

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“…20 Although the exact causal and temporal relationship of pancreatitis and preeclampsia has not been established, increasingly, case reports and small studies in the literature have attempted to demonstrate an association. [10][11][12][13][14][15][16][17] Our findings of an association between hypertensive disease and pancreatitis during pregnancy corroborate these publications.…”

Section: Hacker Et Alsupporting

confidence: 94%

Maternal and fetal outcomes of pancreatitis in pregnancy

Hacker

Whalen

Lee

et al. 2015

American Journal of Obstetrics and Gynecology

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Section: Hacker Et Alsupporting

confidence: 94%

Maternal and fetal outcomes of pancreatitis in pregnancy

Hacker

Whalen

Lee

et al. 2015

American Journal of Obstetrics and Gynecology

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“…The main impact of preeclampsia on the fetus is malnourishment, resulting from uteroplacental vascular insufficiency hypoxia, which restricts nutrient supplies and oxygen flow from the placenta to the fetus [18, 19], which affects approximately 30% of preeclampsia cases. This leads to various perinatal and neonatal problems, including intrauterine growth restriction (IUGR, defined as birth weight less than the 10th percentile) [6, 18, 20–25], emergency C-section [6], preterm delivery [24, 26, 27], reduced birth weight [6, 28, 29], lower APGAR scores [30], more frequent and prolonged neonatal intensive care unit (NICU) stays [6, 20, 31], and increased acute respiratory distress syndromes after birth [32]. In some cases, fetal damage is so severe that it results in fetal demise, such as stillbirth and neonatal death [32, 33].…”

Section: Preeclampsia Genomic Imprinting and Child Neurobehavioral mentioning

confidence: 99%

“…In some cases, fetal damage is so severe that it results in fetal demise, such as stillbirth and neonatal death [32, 33]. Beyond birth, while the long-term health and developmental consequences of exposure to maternal preeclampsia for the surviving child are relatively unexplored, there is some evidence for suboptimal neurocognitive development among infants with IUGR [34, 35], which is one of the major fetal/child consequences of preeclampsia [6, 20–25]. Recently, with the leadership of the NICHD, growing efforts have been made to find associations between preeclampsia and health consequences in offspring, including IUGR [34–36], preterm birth [37–40], LBW [41–43], and child neurobehavioral development [44–46].…”

Section: Preeclampsia Genomic Imprinting and Child Neurobehavioral mentioning

confidence: 99%

Neurodevelopmental consequences in offspring of mothers with preeclampsia during pregnancy: underlying biological mechanism via imprinting genes

Nomura

Roshan

Janssen

et al. 2017

Arch Gynecol Obstet

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Purpose Preeclampsia is known to be a leading cause of mortality and morbidity among mothers and their infants. Approximately 3–8% of all pregnancies in the US are complicated by preeclampsia and another 5–7% by hypertensive symptoms. However, less is known about its long-term influence on infant neurobehavioral development. The current review attempts to demonstrate new evidence for imprinting gene dysregulation caused by hypertension, which may explain the link between maternal preeclampsia and neurocognitive dysregulation in offspring. Method Pub Med and Web of Science databases were searched using the terms “preeclampsia,” “gestational hypertension,” “imprinting genes,” “imprinting dysregulation,” and “epigenetic modification,” in order to review the evidence demonstrating associations between preeclampsia and suboptimal child neurodevelopment, and suggest dysregulation of placental genomic imprinting as a potential underlying mechanism. Results The high mortality and morbidity among mothers and fetuses due to preeclampsia is well known, but there is little research on the long-term biological consequences of preeclampsia and resulting hypoxia on the fetal/child neurodevelopment. In the past decade, accumulating evidence from studies that transcend disciplinary boundaries have begun to show that imprinted genes expressed in the placenta might hold clues for a link between preeclampsia and impaired cognitive neurodevelopment. A sudden onset of maternal hypertension detected by the placenta may result in misguided biological programming of the fetus via changes in the epigenome, resulting in suboptimal infant development. Conclusion Furthering our understanding of the molecular and cellular mechanisms through which neurodevelopmental trajectories of the fetus/infant are affected by preeclampsia and hypertension will represent an important first step toward preventing adverse neurodevelopment in infants.

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“…For mother’s health, severe preeclampsia may cause symptoms such as hypertension, proteinuria, eclampsia, cerebral edema, cerebral hemorrhage, long-term neuro-cognitive dysfunction, blindness, liver swelling, and other liver damage leading to elevated serum transaminase, oliguria, thrombocytopenia, pulmonary edema necrotizing pancreatitis, all of which could be fatal to mothers and their unborn child in-utero, as well as causing various degree of child morbidity after birth (Williams et al, 2010; Swank, Nageotte, & Hatfield, 2012). The main impact of preeclampsia to the fetus is under-nutrition, resulting from utero-placental vascular insufficiency hypoxia, which restricts nutrient supplies and oxygen flow from the placenta to the fetus (Kajantie, Thornburg, Eriksson, Osmond, & Barker, 2010).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Preeclampsia on Perinatal Risks and Infant Temperaments Among Mothers With Antenatal Depression

Nomura

Finik

Salzbank

et al. 2014

JPR

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Importance Preeclampsia and depression are two most prevalent disorders known to affect pregnant women and unborn infant. However, few studies have prospectively examined the adverse influence of the in-utero exposures to the two disorders on the optimal development in their offspring, including mortality, adverse birth outcomes, and infant temperament styles. Objectives (1) To examine whether exposures to preeclampsia and antenatal depression were associated with developmental indices of offspring at birth and temperament at 3 months; and (2) To evaluate how preeclampsia and antenatal depression associated with offspring temperamental style. Design Prospective cohort study with regular assessment of mother’s blood pressure at each prenatal visit: offspring were followed till 3 months. Setting Two prenatal clinics, New York City, USA. Participants A cohort of 233 pregnant women was followed throughout pregnancy. Of those, 141 provided ratings of infant temperament at three months. Exposures Diagnostic outcome of maternal depression by clinical interviewers blind to preeclampsia status, were ascertained using the Structured Clinical Interview for DSM-IV Axis I Disorders. The development of preeclampsia, defined by the onset of hypertension (> 140/90 mm HG) after 20 weeks’ gestation, accompanied by 300 mg of protein, monitored via electronic medical records. Main Outcome Measures Birth outcomes were assessed via standardized ratings at delivery. Infant temperament was reported by the mother at three months, using 91-item IBQ-R (Infant Behavioral Questionnaire-Revised). Results Preeclampsia was associated with an over 5-fold increased risk for fetal/infant mortality, a 3- to 7-fold increased risk for poorer birth outcomes, and flatter affect and distress in infants. Furthermore, infants born to preeclamptic mothers with co-occurring depression displayed lower levels of smile/laughter, high-intensity pleasure seeking behavior, perceptual sensitivity, and approach behavior. Conclusion Preeclampsia was associated with a few difficult temperament styles in the first three months after birth. Moreover, its negative impact was amplified by mother’s antenatal depression. Our findings regarding additive risk for negative infant outcomes in babies exposed to preeclampsia and antenatal depression suggests that the development of early detection programs to identify and monitor women who are at heightened risk for these conditions can potentially have a positive influence on long-term infant neurobehavioral development.

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Necrotizing Pancreatitis Associated With Severe Preeclampsia

Abstract: Severe preeclampsia may cause widespread end-organ damage and may affect the gastrointestinal system, resulting in fatal necrotizing pancreatitis.

Cited by 16 publications

References 4 publications

Maternal and fetal outcomes of pancreatitis in pregnancy

Maternal and fetal outcomes of pancreatitis in pregnancy

Neurodevelopmental consequences in offspring of mothers with preeclampsia during pregnancy: underlying biological mechanism via imprinting genes

The Effects of Preeclampsia on Perinatal Risks and Infant Temperaments Among Mothers With Antenatal Depression

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