Necropsy Findings in Rhesus Monkeys Experimentally Infected with Cultured Simian Immunodeficiency Virus (SIV)/Delta

Abstract

Abstract. Lesions induced in rhesus monkeys by different isolates of simian immunodeficiency virus (SIV)/ Delta were studied at necropsy. Four groups of monkeys were inoculated with SIV/Delta isolated from other experimentally infected rhesus monkeys, while one group was inoculated with SIV/Delta from an asymptomatic mangabey monkey. Three rhesus isolates and the mangabey isolate were virulent, killing 75-100% of infected monkeys. One rhesus isolate, which had been extensively passaged in vitro, was attenuated but was restored to virulence by single animal passage. Clinically, infected monkeys had lymphadenopathy, splenomegaly, diarrhea, and a rash. Most monkeys died of enteric disease. The following lesions were seen: weight loss, thymic atrophy, lymphoid atrophy, bone marrow hyperplasia, encephalitis, colitis, amyloidosis, hepatitis, glomerulosclerosis, and the presence of syncytial cells. One Rh Epstein-Barr virus (EBV)-related lymphoma occurred. Opportunistic agents were identified: cytomegalovirus, adenovirus, Cryptosporidia, and Pneumocystis. Shigella and Campylobacter often caused colitis.

Expression of Simian Immunodeficiency Virusnefin Immune Cells of Transgenic Mice Leads to a Severe AIDS-Like Disease

“…In contrast, wasting without diarrhea was frequent in CD4C/SHIV-nef SIV Tg mice, most likely because they were housed in an SPF facility. Kidney (5,7,25,65) and lung (25,51) diseases have also been described in SAIDS. Similarly, cardiac disease is found in SIV-infected primates (60).…”

“…Premature death is frequent in SAIDS (7,10,40). Wasting disease and failure to thrive, in the absence of detectable secondary pathogens, has also been described in SAIDS (35,66); such wasting is usually correlated with a high incidence of diarrhea (7,36), often caused by pathogenic bacteria or protozoa. In contrast, wasting without diarrhea was frequent in CD4C/SHIV-nef SIV Tg mice, most likely because they were housed in an SPF facility.…”

The SIV-infected rhesus monkey model for HIV-associated dementia and implications for neurological diseases

“…In the model described here, SIV B670 was selected for use because of its neuroinvasiveness and neurovirulence [34,39]. Neuroinvasiveness refers to the ability of the virus to penetrate and infect CNS tissues, and neurovirulence refers to the ability to yield neuropathological and functional abnormalities.…”

Early phenotypic and functional alterations in lymphocytes from simian immunodeficiency virus infected macaques

“…Thus, these two genetically closely related viruses (Chakrabarti et a1., 1987;Franchini et al, 1987) both use the CD4 moleeule as receptor (Kannagi et a1., 1985;SchnitÜnan et a1., 1989) and 'caiJse. an immunodeficiency syndrome inthelt respective bosts (Letviri etat, 1985;Baskin et al, 1988;Beneviste el a1. , 1988;Fultz ef a1., 1989).…”