Necrobiosis Lipoidica: A Descriptive Study of 35 Cases

Marcoval, Joaquim; Gómez-Armayones, S.; Valentí-Medina, F.; Bonfill-Ortí, Montserrat; Martínez-Molina, L.

doi:10.1016/j.adengl.2015.04.008

Cited by 7 publications

(10 citation statements)

References 17 publications

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“…Necrobiosis lipoidica is a chronic granulomatous dermatitis, and the peak age for presentation has been reported to be in the third and fourth decades . It is very rare in the pediatric population, and only a few isolated cases have been reported in individuals below the age of 10 years, all of which were patients with diabetes .…”

Section: Discussionmentioning

confidence: 99%

“…Lesions on the face, scalp, trunk, groin, and upper extremities have also been reported . In a study of 35 patients by Marcoval et al, the authors found only 1 patient who had lesions in areas other than tibial region . There are few case reports of NL affecting the back, and none were in children .…”

Section: Discussionmentioning

confidence: 99%

“…wileyonlinelibrary.com/journal/pde fourth decades. 4 It is very rare in the pediatric population, and only a few isolated cases have been reported in individuals below the age of 10 years, all of which were patients with diabetes. 3 The sex distribution of cohort studies showed a woman predominance.…”

Section: Discussionmentioning

confidence: 99%

“…5 In a study of 35 patients by Marcoval et al, the authors found only 1 patient who had lesions in areas other than tibial region. 4 There are few case reports of NL affecting the back, and none were in children. 6 In addition, our patient had a single large plaque, which is very rare, because NL lesions typically present as 1 to 3 asymptomatic, well-circumscribed papules and nodules.…”

Section: Discussionmentioning

confidence: 99%

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Atypical presentation of necrobiosis lipoidica in a pediatric patient

Özkur

Hasçiçek

Altunay

2018

Pediatric Dermatology

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Necrobiosis lipoidica (NL) is a rare chronic granulomatous inflammatory skin disease characterized by brownish‐red papules and yellowish plaques with atrophic centers, which usually affect the legs, bilaterally. The average age of onset is 30‐40 years, and there are very few reported cases of necrobiosis lipoidica in children. A nondiabetic girl aged 14 years presented to our clinic with a history of an asymptomatic, 7 × 5‐cm single red plaque over her back in the interscapular area, which had started 5 years ago. Her laboratory tests were normal. A histopathologic evaluation confirmed the diagnosis of NL, and local treatment with clobetasol propionate twice daily was administrated. The patient will be followed up to monitor plasma glucose levels and evaluation of the lesion. Herein, we report a pediatric patient without diabetes mellitus who had NL in an atypical location and review the literature in view of the clinical features, complications, and treatment regimens for NL in children.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Atypical presentation of necrobiosis lipoidica in a pediatric patient

Özkur

Hasçiçek

Altunay

2018

Pediatric Dermatology

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“…Estudios posteriores han disminuido esta cifra hasta situarla en el 11%, si bien, en el seguimiento posterior a cinco años, hasta un 5 % más de los pacientes estudiados desarrollaron DM o intolerancia a la glucosa 5 . En un reciente estudio publicado por un grupo español donde se incluyen 35 pacientes con NL, se calcula una prevalencia de DM del 65 % 6 .…”

Section: Etiopatogenia Y Asociación a Otros Procesosunclassified

Necrobiosis lipoídica

Morales-Raya¹,

Postigo‐Llorente²

2017

Más Dermatol

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artículo de revisión INTRODUCCIÓNLa necrobiosis lipoídica (NL) es un proceso cutáneo crónico granulomatoso y de etiología desconocida. Se caracteriza por una degeneración del colágeno de la dermis, con formación de granulomas y acumulación histiocitaria.Tradicionalmente, la NL se ha asociado epidemiológicamente de forma muy estrecha a la diabetes mellitus (DM), sin embargo, no se ha podido establecer una asociación causal firme.Clínicamente, se caracteriza por la formación de placas amarillentas de piel atrófica y bordes de aspecto inflamatorio de localización preferentemente pretibial. Ocasionalmente, estas placas pueden ser dolorosas y ulcerarse, suponiendo un reto terapéutico para el dermatólogo.Existen multitud de referencias en la literatura en cuanto al tratamiento de la NL, si bien, no se dispone de un protocolo estandarizado de tratamiento, siendo muchas de estas terapias mediocres en cuanto a eficacia y evidencia, y necesitándose estudios serios que avalen su uso. EPIDEMIOLOGÍALa NL se considera una enfermedad rara, que afecta de forma más frecuente a adultos jóvenes y de media- REsUMENLa necrobiosis lipoídica es una rara enfermedad cutánea granulomatosa y crónica, estrechamente relacionada con la diabetes mellitus, de etiopatogenia desconocida. Complicaciones como la ulceración ocurren hasta en un tercio de los pacientes y pueden llegar a suponer un gran reto terapéutico. Se han ensayado multitud de posibles terapias; la mayoría de ellas con resultados mediocres. Con esta revisión, se pretende una puesta al día en la etiopatogenia, los tratamientos disponibles y las nuevas posibles armas terapéuticas.Palabras clave: necrobiosis lipoídica, diabetes mellitus, granulomas, úlceras. AbsTRACTNecrobiosis lipoidica is a rare chronic inflammatory granulomatous skin disorder closely related to diabetes mellitus with an unknown pathogenesis. Complications such as ulceration are common and can be challenging to treat. Many treatments have been tried, most of them with poor results. Our aim with this review is an update in the pathogenesis, available therapies and new possible therapeutic approach.

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Cutaneous Granulomatosis: a Comprehensive Review

Beretta‐Piccoli

Mainetti

Peeters³

et al. 2018

Clinic Rev Allerg Immunol

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Cutaneous granulomatosis is a heterogeneous group of diseases, characterized by a skin inflammatory reaction triggered by a wide variety of stimuli, including infections, foreign bodies, malignancy, metabolites, and chemicals. From a pathogenic point of view, they are divided into non-infectious and infectious granulomas. Pathophysiological mechanisms are still poorly understood. Non-infectious granulomatous skin diseases include granuloma annulare, necrobiosis lipoidica, rheumatic nodules, foreign body granulomas, cutaneous sarcoidosis, and interstitial granulomatous dermatitis. Necrobiosis lipoidica is more frequent in diabetic patients. Infectious granulomas of the skin are caused by mycobacteria, in particular Mycobacterium tuberculosis or atypical mycobacteria; parasites, such as Leishmania; or fungi. Pathogenic mechanisms of M. tuberculosis-related granuloma are discussed. From a clinical point of view, it is useful to divide cutaneous granulomatosis into localized and more disseminated forms, although this distinction can be sometimes artificial. Three types of localized granulomatous lesions can be distinguished: palisaded granulomas (granuloma annulare, necrobiosis lipoidica, and rheumatoid nodules), foreign body granulomas, and infectious granulomas, which are generally associated with localized infections. Disseminated cutaneous granulomas can be divided into infectious, in particular tuberculosis, and non-infectious forms, among which sarcoidosis and interstitial granulomatous dermatitis. From a histological point of view, the common denominator is the presence of a granulomatous inflammatory infiltrate in the dermis and/or hypodermis; this infiltrate is mainly composed of macrophages grouped into nodules having a nodular, palisaded or interstitial architecture. Finally, we propose which diagnostic procedure should be performed when facing a patient with a suspected cutaneous granulomatosis.

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Necrobiosis Lipoidica: A Descriptive Study of 35 Cases

Abstract: NL is frequently associated with type 1 and 2 diabetes. Although diabetes tends to develop before NL, it can occur simultaneously.

Cited by 7 publications

References 17 publications

Atypical presentation of necrobiosis lipoidica in a pediatric patient

Atypical presentation of necrobiosis lipoidica in a pediatric patient

Necrobiosis lipoídica

Cutaneous Granulomatosis: a Comprehensive Review

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