Necrectomy Time Justification in Treatment of Frostbite in Experiment

Abstract

Background. One of the main methods that determine the outcome of treatment of victims with deep frostbite is the surgical excision of dead tissue. However, the question of the timeliness of performing necrectomy remains the subject of scientific discussions. Purpose of the study. To establish optimal time of necrectomy in treatment of deep frostbite in an experiment on laboratory rats. Material and methods. Standardized deep contact frostbite was modeled in 45 rats. The laboratory animals were divided into three series, in which frostbite zone necrectomy was performed on the 3rd, 5th and 7th days, respectively. In the postoperative period, daily dressings were performed, followed by a morphological and histological assessment of the dynamics of cold wound healing. Results. Morphodynamic and histological characteristics of the healing of deep frostbite the treatment of which included necrectomy at various time are presented. Conclusions. Surgical intervention on the 5th day after the modeling of deep frostbite is optimal, as it leads to earlier healing of the wound defect in comparison with necrectomy performed on the 3rd or 7th day of the experiment.