Neck Sonography and Suppressed Thyroglobulin Have High Sensitivity for Identifying Recurrent/Persistent Disease in Patients With Low‐risk Thyroid Cancer Treated With Total Thyroidectomy and Radioactive Iodine Ablation, Making Stimulated Thyroglobulin Unnecessary

Domínguez, José Miguel; Nilo, Flavia; Contreras, Tania; Carmona, Rocı́o; Droppelmann, Nicolás; González, Hernán; Iturrieta, Virginia; Tuttle, R. Michael

doi:10.1002/jum.14260

Cited by 9 publications

(4 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, in an era, formerly of ''affordable care,'' does one really expect that the USA and its insurance providers can continue to justify funding the present obsession of clinical endocrinologists with ''super-sensitive'' serum thyroglobulin levels and tiny neck nodal targets seen only by high-resolution sonography [35]? Perhaps only the next 4 or 8 years of ever-changing health policies [34] in the USA will provide the final answer to this relevant and timely question for patients with this most common endocrine malignancy and their physicians.…”

Section: Discussionmentioning

confidence: 99%

Papillary Thyroid Carcinoma (PTC) in Children and Adults: Comparison of Initial Presentation and Long‐Term Postoperative Outcome in 4432 Patients Consecutively Treated at the Mayo Clinic During Eight Decades (1936–2015)

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Papillary Thyroid Carcinoma (PTC) in Children and Adults: Comparison of Initial Presentation and Long‐Term Postoperative Outcome in 4432 Patients Consecutively Treated at the Mayo Clinic During Eight Decades (1936–2015)

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Thyroid hormones are also monitored annually because 29% of patients can develop hypothyroidism after hemithyroidectomy . Following total thyroidectomy, annual thyroid ultrasonography, thyroglobulin levels, thyroglobulin antibody levels, and thyrotropin levels are used to detect persistent/recurrent disease in patients with low-risk thyroid cancer (Table 1). Thyrotropin suppression is not recommended for patients with low-risk thyroid cancer due to its excellent prognosis, and less frequent thyroid ultrasounds (approximately yearly or every 2 years depending on response to therapy) are encouraged .…”

Section: Methodsmentioning

confidence: 99%

Thyroid Cancer

Boucai,

Zafereo,

Cabanillas

2024

JAMA

View full text Add to dashboard Cite

ImportanceApproximately 43 720 new cases of thyroid carcinoma are expected to be diagnosed in 2023 in the US. Five-year relative survival is approximately 98.5%. This review summarizes current evidence regarding pathophysiology, diagnosis, and management of early-stage and advanced thyroid cancer.ObservationsPapillary thyroid cancer accounts for approximately 84% of all thyroid cancers. Papillary, follicular (≈4%), and oncocytic (≈2%) forms arise from thyroid follicular cells and are termed well-differentiated thyroid cancer. Aggressive forms of follicular cell-derived thyroid cancer are poorly differentiated thyroid cancer (≈5%) and anaplastic thyroid cancer (≈1%). Medullary thyroid cancer (≈4%) arises from parafollicular C cells. Most cases of well-differentiated thyroid cancer are asymptomatic and detected during physical examination or incidentally found on diagnostic imaging studies. For microcarcinomas (≤1 cm), observation without surgical resection can be considered. For tumors larger than 1 cm with or without lymph node metastases, surgery with or without radioactive iodine is curative in most cases. Surgical resection is the preferred approach for patients with recurrent locoregional disease. For metastatic disease, surgical resection or stereotactic body irradiation is favored over systemic therapy (eg, lenvatinib, dabrafenib). Antiangiogenic multikinase inhibitors (eg, sorafenib, lenvatinib, cabozantinib) are approved for thyroid cancer that does not respond to radioactive iodine, with response rates 12% to 65%. Targeted therapies such as dabrafenib and selpercatinib are directed to genetic mutations (BRAF, RET, NTRK, MEK) that give rise to thyroid cancer and are used in patients with advanced thyroid carcinoma.ConclusionsApproximately 44 000 new cases of thyroid cancer are diagnosed each year in the US, with a 5-year relative survival of 98.5%. Surgery is curative in most cases of well-differentiated thyroid cancer. Radioactive iodine treatment after surgery improves overall survival in patients at high risk of recurrence. Antiangiogenic multikinase inhibitors and targeted therapies to genetic mutations that give rise to thyroid cancer are increasingly used in the treatment of metastatic disease.

show abstract

“…The ATA and NCCN guidelines recommend repeated Tg measurement with rhTSH stimulation when the initial Tg value is undetectable. Some researchers showed that rhTSH-stimulated Tg value did not change the postoperative management if suppressed Tg was <1 ng/ml and neck ultrasound was negative ( 68 , 69 ). Castagna et al.…”

Section: The Role Of Tg In Postoperative Patients With Dtcmentioning

confidence: 99%

The Role of Thyroglobulin in Preoperative and Postoperative Evaluation of Patients With Differentiated Thyroid Cancer

Ren

Gong

et al. 2022

Front. Endocrinol.

View full text Add to dashboard Cite

Thyroglobulin (Tg) is secreted by thyroid follicular cells and stored in the thyroid follicular lumen as a component of thyroid hormone. It is known that both benign and well-differentiated malignant thyroid tissue can secrete Tg. In recent years, growing lines of evidence have shown that Tg plays an important role in the diagnosis and metastasis of preoperative differentiated thyroid carcinoma (DTC). The levels of Tg, whether in the serum or in a fine-needle aspiration washout fluid, are usually viewed as an excellent indicator in the monitoring of postoperative DTC, including the guidance and evaluation of radioactive iodine ablation. Nevertheless, some factors limit the application of Tg, such as the method used to measure Tg and the presence of Tg antibodies. This review aimed to summarize the role of Tg in the preoperative and postoperative evaluation of patients with DTC, and the factors influencing Tg. This review could provide a reference for a more accurate application of Tg in patients with DTC.

show abstract

Neck Sonography and Suppressed Thyroglobulin Have High Sensitivity for Identifying Recurrent/Persistent Disease in Patients With Low‐risk Thyroid Cancer Treated With Total Thyroidectomy and Radioactive Iodine Ablation, Making Stimulated Thyroglobulin Unnecessary

Cited by 9 publications

References 32 publications

Papillary Thyroid Carcinoma (PTC) in Children and Adults: Comparison of Initial Presentation and Long‐Term Postoperative Outcome in 4432 Patients Consecutively Treated at the Mayo Clinic During Eight Decades (1936–2015)

Papillary Thyroid Carcinoma (PTC) in Children and Adults: Comparison of Initial Presentation and Long‐Term Postoperative Outcome in 4432 Patients Consecutively Treated at the Mayo Clinic During Eight Decades (1936–2015)

Thyroid Cancer

The Role of Thyroglobulin in Preoperative and Postoperative Evaluation of Patients With Differentiated Thyroid Cancer

Contact Info

Product

Resources

About