Neck mass as the first presentation of testicular choriocarcinoma

Ahmadi, Sayed Ali; Tavakoli, Hassan; Samadi, Nasrin

doi:10.1007/s00405-005-0982-6

Cited by 9 publications

(11 citation statements)

References 4 publications

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“…2 The most common sites of metastasis of testicular germ cell tumors are the retroperitoneal lymph nodes, lungs, and liver. 2,3 • In 1973, Flocks and Boatman categorized genitourinary malignancies according to the incidence of head and neck metastasis. 15 They found that 13% of testicular malignancies metastasized to the head and neck region.…”

Section: Discussionmentioning

confidence: 99%

“…1 Choriocarcinoma is a rare, highly malignant tumor of the testes, and it usually occurs as a component of mixed germ cell tumor. 3 The incidence of testicular carcinoma metastatic to the neck has been reported to be 5%. 3 Even more uncommon is a finding of choriocarcinoma as a neck mass without any sign of a primary testicular tumor, as only a few such cases have been published in the literature.…”

Section: Introductionmentioning

confidence: 99%

“…3 The incidence of testicular carcinoma metastatic to the neck has been reported to be 5%. 3 Even more uncommon is a finding of choriocarcinoma as a neck mass without any sign of a primary testicular tumor, as only a few such cases have been published in the literature. 3 In this article, we report a new case.…”

Section: Introductionmentioning

confidence: 99%

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Metastatic Choriocarcinoma: A Rare Presentation as a Neck Mass

Şenkal

Yılmaz

Sözeri

2013

Ear, Nose & Throat Journal

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Testicular carcinoma metastatic to the neck is rare. Even more rare is a finding of choriocarcinoma as a neck mass without any sign of a primary testicular tumor, as only a few cases have been reported in the literature. We describe a new case that occurred in a 29-year-old man who presented with a neck mass. Fine-needle aspiration biopsy identified the tumor as a malignant epithelial neoplasm. Radiologic findings indicated the presence of a systemic metastasis of a tumor to the chest and abdomen, as well as the neck. Findings on an incisional biopsy of the neck mass were consistent with a choriocarcinoma. The testicles were normal on palpation and ultrasonography. The patient was diagnosed with metastatic choriocarcinoma with an unknown primary, and he was started on chemotherapy. On the second day of treatment, which was 25 days after his referral to our clinic, he died of respiratory insufficiency.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Metastatic Choriocarcinoma: A Rare Presentation as a Neck Mass

Şenkal

Yılmaz

Sözeri

2013

Ear, Nose & Throat Journal

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“…While the second case from Zangana et al 5 reported a pure teratoma with a smaller mass size. There are few reports of subcutaneous metastasis from germ cell tumours in general, with some authors suggesting that subcutaneous tissue could be the primary [6][7][8] origin of these germ cell tumours. [9][10][11] In addition to reporting this unusual presentation, we also stress upon two other observations.…”

Section: Discussionmentioning

confidence: 99%

A very unusual metastatic pattern exhibited by a mixed non-seminomatous germ cell tumour: a case report and review of literature

Osman

Gomha

Aldayel

2013

Journal of Clinical Urology

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It is a known fact that the retroperitoneum is the commonest metastatic site for testicular germ cell tumours. Contrary to this we are hereby reporting a case of an advanced testicular non-seminomatous germ cell tumour (NSGCT) presenting with a huge anterior abdominal wall metastatic mass and no evidence of retroperitoneal lymphadenopathy. A 36 yearold gentleman who underwent bilateral orchidopexies as a child, presented with a huge anterior abdominal wall mass engulfing the external genitalia. Incisional biopsy showed a yolk sac tumour. He was treated primarily with immediate chemotherapy with a dramatically good response. This was followed by right radical orchidectomy. Unfortunately, a few months later he developed recurrences into the anterior abdominal wall as well as brain metastasis. We conclude with two main messages. Firstly, previous inguino-scrotal procedures can significantly alter the lymphatic drainage from the testicles. Secondly, primary chemotherapy before orchidectomy can have a very favourable outcome in selected patients.

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“…Choriocarcinoma is a highly malignant uncommon tumor of the testis, and it usually occurs as a component of mixed germ cell tumor (1). The testicular enlargement may be subtle, and the patient may present with multiple metastasis.…”

Section: Introductionmentioning

confidence: 99%

Mixed Testicular Germ Cell Tumor Presenting as Metastatic Pure Choriocarcinoma Involving Multiple Lung Metastases That Was Effectively Treated with High-dose Chemotherapy

Lee

Kim

et al. 2009

Cancer Res Treat

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I n t r o d u c t i o nChoriocarcinoma is a highly malignant uncommon tumor of the testis, and it usually occurs as a component of mixed germ cell tumor (1). The testicular enlargement may be subtle, and the patient may present with multiple metastasis. Early metastases are usually found in most of these patients, and they most commonly occur in the lung, liver and brain. There is often marked elevation of the serum levels of human chorionic gonadotropin (hCG) (2). On gross examination, choriocarcinomas of the testis are often small and the involved testes may appear normal.Metastasis from a testicular mixed germ cell tumor as pure choriocarcinoma is also uncommon (3). We report here on one case of metastatic pure choriocarcinoma with aggressive lymph node metastases and multiple pulmonary metastases, and the patient achieved complete remission after high-dose chemotherapy with autologous stem cell transplantation. C a s e R e p o r tA 33-year-old previously healthy man was referred to Soonchunhyang University Hospital, Korea in December 2006. He complained of abdominal pain, and numerous pulmonary nodules in both lungs had previously been incidentally detected. The patient had a one-month history of progressive abdominal pain and weight loss of 7 kg. No other signs and symptoms had been noted except for dyspepsia and questionable chest tightness. The patient had an acutely ill-looking appearance, and the physical examination of the other systems was unremarkable. His external genitalia were not examined at the first visit. The laboratory findings showed an elevated level of lactate dehydrogenase (LDH) of 1,156 U/L (reference range: 100� 450 U/L) and an elevated level of β -HCG of 174,156.56 mIU/mL (reference range: 0�5 mIU/mL). The initial tests for the WBC, hemoglobin and alpha-fetoprotein (AFP) were 10,000/μ L (reference: 4,000�10,000/μ L), 13.3 g/dL (reference: 13�17 g/dL) and 0.99 Choriocarcinoma in the testis is very rare, and it represents less than 1% (0.3%) of all the testicular germ cell tumors. It is a particularly aggressive variant of non-seminoma tumor, which is characterized by a high serum β -HCG level and multiple lung metastases. The optimal management for this disease remains undefined. We report here on a case of choriocarcinoma with multiple lung metastases, and the patient has achieved continuous remission for 2 years after combination chemotherapy of BEP (bleomycin, etoposide and cisplatin) and sequential high-dose chemotherapy with autologous peripheral stem cell rescue.

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Neck mass as the first presentation of testicular choriocarcinoma

Cited by 9 publications

References 4 publications

Metastatic Choriocarcinoma: A Rare Presentation as a Neck Mass

Metastatic Choriocarcinoma: A Rare Presentation as a Neck Mass

A very unusual metastatic pattern exhibited by a mixed non-seminomatous germ cell tumour: a case report and review of literature

Mixed Testicular Germ Cell Tumor Presenting as Metastatic Pure Choriocarcinoma Involving Multiple Lung Metastases That Was Effectively Treated with High-dose Chemotherapy

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