Metastatic Choriocarcinoma: A Rare Presentation as a Neck Mass

Şenkal, Hilmi Alper; Yılmaz, Taner; Sözeri, Ahmet Bülent

doi:10.1177/014556131309200622

Cited by 6 publications

(3 citation statements)

References 17 publications

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“…The overall incidence of malignant metastasis to the skin is between 1-and 4% [ 13 ]. There are some case reports of testicular or non-gestational choriocarcinoma metastasizing to the skin [ 14 – 17 ] but to the best of our knowledge, there are only eleven cases of GTN with meta-static skin lesions have been reported in the English language [ 10 , 11 , 13 , 18 – 24 ] ( Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Combined Choriocarcinoma and Placental Site Trophoblastic Tumor Presenting as Skin Lesion: A Case Report

et al. 2022

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Patient: Female, 41-year-old Final Diagnosis: Choriocarcinoma • gestational thropoblastic neoplasia • placental site tumor Symptoms: Headache • scalp swelling • soft tissue swelling Medication: — Clinical Procedure: — Specialty: Dermatology • Obstetrics and Gynecology • Oncology Objective: Unusual clinical course Background: Despite the tendency to metastasize widely, Gestational Trophoblastic Neoplasia (GTN) is one of the most curable solid tumors with chemotherapy. Case Report: A 41-year-old female, G4P2A2, presented with a slowly growing lump on the left side of the scalp associated with a headache. The patient had intermittent, sharp left eye pain which radiated to the side of her face, photophobia, early morning blurring of vision, and nausea. Palpation over scalp lesion produced deep retro-orbital pain and pain was exacerbated with bending over. An ophthalmological evaluation was unremarkable. Ultrasonography (USG) of the left scalp showed an intramuscular mass superficial to the left frontal bone. During excision biopsy, the mass was found to be invading the frontal bone. Histopathology showed a metastatic trophoblastic tumor with mixed features of choriocarcinoma and placental site trophoblastic tumor. A pregnancy test was positive, the beta HCG level was elevated but USG did not show intrauterine pregnancy. CT head demonstrated an intracranial, dural-based mass that extended against the brain but did not breach the pial membrane. CT chest, abdomen, pelvis, and PET scan showed no evidence of metastatic disease. She was successfully treated with resection of the transcranial lesion followed by aggressive chemotherapy – Etoposide, Methotrexate, Actinomycin-D, Vincristine, and Cyclophosphamide. Conclusions: This was an unusual case of GTN due to its primary presentation as skin metastasis, without any lung metastasis and no identifiable primary lesion. It is also very unusual to see a combination of choriocarcinoma and placental site trophoblastic tumor cells in the same tumor mass.

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Section: Discussionmentioning

confidence: 99%

A Rare Case of Combined Choriocarcinoma and Placental Site Trophoblastic Tumor Presenting as Skin Lesion: A Case Report

et al. 2022

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“…10 Lauro et al have described stomach tumor when patients presented with a chief complaint of hematemesis. 11 Vardaros et al reported a case of duodenal metastasis from choriocarcinoma, 12 and Senkal et al 13 and Ahmadi et al 14 have independently reported cases of neck masses as the primary presentation in cases of testicular choriocarcinoma. Toberer et al reported a case of cutaneous metastasis from underlying choriocarcinoma, in which the patient had an extremely high disease load and died within 9 days of treatment initiation.…”

Section: Discussionmentioning

confidence: 99%

Testicular Choriocarcinoma with Inexplicably High Beta-human Chorionic Gonadotropin and Renal Metastases

Sarin¹,

Bansal²,

Kaur³

et al. 2021

Oncology &Amp; Hematology Review (US)

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“…Extragonadal non-gestational midline ChC is a malignant, germ cell tumor composed of extraembryonic chorion that includes cytotrophoblastic and syncytiotrophoblastic cells, representing an incidence of 0.0022 per 1,000,000 people [6]. There are a few case reports of extragonadal midline ChC metastasizing to cervical lymph nodes [15], but to date, an oropharyngeal extragonadal nongestational ChC has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Extragonadal Non-gestational Choriocarcinoma with Tonsillar Presentation

Payne

Palma

Walker

et al. 2020

Head and Neck Pathol

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Extragonadal non-gestational choriocarcinoma is a rare but well-described phenomenon occurring in patients with midline germ cell tumors. Choriocarcinoma (ChC) is an aggressive neoplasm usually developing in women as a rare complication of pregnancy. In male patients ChC occurs in the testes, usually as a component of mixed germ cell tumors. Very few patients develop extragonadal choriocarcinoma with the tumor occurring in midline locations, such as the mediastinum, retroperitoneum, and central nervous system (mostly pineal gland). Non-midline choriocarcinoma can occur in the lung, gastrointestinal tract, and breast, sometimes blended with another primary malignancy. A midline choriocarcinoma manifesting as a head and neck malignancy is exceptional. During an evaluation of multiple enlarged cervical lymph nodes suspected to be lymphoma in a 72-year-old man, a core biopsy was taken from one of the left neck lymph nodes which histologically showed a necrotic malignancy with strong diffuse pancytokeratin staining. After an initial interpretation of metastatic carcinoma, further samples were taken from both tonsils and from a right level 5 neck lymph node. Histologically, all samples contained the same tumor, showing profound pleomorphism and multinucleated syncytial-type giant cells. A panel of immunohistochemistry studies were performed, including β-human chorionic gonadotropin, with positive findings leading to a diagnosis of extragonadal non-gestational choriocarcinoma.

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Metastatic Choriocarcinoma: A Rare Presentation as a Neck Mass

Cited by 6 publications

References 17 publications

A Rare Case of Combined Choriocarcinoma and Placental Site Trophoblastic Tumor Presenting as Skin Lesion: A Case Report

A Rare Case of Combined Choriocarcinoma and Placental Site Trophoblastic Tumor Presenting as Skin Lesion: A Case Report

Testicular Choriocarcinoma with Inexplicably High Beta-human Chorionic Gonadotropin and Renal Metastases

Extragonadal Non-gestational Choriocarcinoma with Tonsillar Presentation

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