Neck Circumference Is Associated With Hyperuricemia in Women With Polycystic Ovary Syndrome

Yang, Haisong; Liu, Chang; Jin, Congcong; Yu, Rong; Ding, Lin; Mu, Liangshan

doi:10.3389/fendo.2021.712855

Cited by 12 publications

(9 citation statements)

References 49 publications

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“…UA/Cr ratio was positively correlated with BMI, WC, TG, LDL-C, HOMA-IR, and negatively correlated with HDL-C even in subjects with normal serum uric acid levels and different glucose tolerance states [23]. We found a positive correlation between UA/Cr ratio and neck circumference, this is in parallel with Yang et al [24] who identified a positive correlation between neck circumference and hyperuricemia in women with PCOS. Upper body adiposity leads to excess free fatty acid release and high airway pressure with consequent oxidative stress and insulin resistance [25].…”

Section: Discussionsupporting

confidence: 88%

Serum uric acid/creatinine ratio and free androgen index are synergistically associated with increased risk of polycystic ovary syndrome in obese women

El-Eshmawy

Ibrahim²,

Bahriz³

et al. 2022

BMC Endocr Disord

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Background Features of metabolic syndrome such as abdominal obesity, insulin resistance, hypertension and dyslipidemia are commonly encountered in polycystic ovary syndrome (PCOS). Recent evidence has suggested an association between high serum uric acid/creatinine (UA/Cr) ratio and metabolic syndrome however, no studies have investigated this association in PCOS. The current study was conducted to investigate the relationship between UA/Cr ratio and PCOS and to identify whether UA/Cr ratio and free androgen index (FAI) have an additive interaction for detection of PCOS risk in obese women. Methods This study enrolled 40 obese women with PCOS and 40 control women with regular menstrual cycles matched for age and body mass index (BMI). Anthropometric measurements, fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), lipids profile, luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol, dehydroepiandrosterone sulfate (DHEAS), sex hormone binding globulin (SHBG), total testosterone, free androgen index (FAI), UA/Cr ratio were assessed. Results Serum UA/Cr ratio was significantly higher in obese women with PCOS than in non-PCOS women. UA/Cr ratio was correlated with BMI, waist and neck circumferences, blood pressure, fasting insulin, HOMA-IR, lipids, LH/FSH, estradiol, DHEAS, total testosterone, FAI and SHBG. UA/Cr ratio and FAI were independent risk factors for PCOS in obese women however, the addictive interaction between UA/Cr ratio and FAI had a higher fold risk (OR: 4.3, 95% CI, 3.4–7.58) and a more significance (P = 0.002) for determination of PCOS. Conclusion Serum UA/Cr ratio combined with FAI can exert an additive or synergistic impact on prediction of PCOS in obese women.

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Section: Discussionsupporting

confidence: 88%

Serum uric acid/creatinine ratio and free androgen index are synergistically associated with increased risk of polycystic ovary syndrome in obese women

El-Eshmawy

Ibrahim²,

Bahriz³

et al. 2022

BMC Endocr Disord

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“…Thus, it contributes to a collection of metabolic abnormalities, including decreased glucose tolerance and insulin sensitivity. Second, recent compelling evidence indicates that NC is independently associated with hyperuricemia in women with PCOS, and elevated serum uric acid levels have been well acknowledged as a risk factor for metabolic risk factors [25]. Third, it has been demonstrated that NC is a reliable indicator for insulin resistance in women with PCOS [13].…”

Section: Discussionmentioning

confidence: 99%

“…Hormonal and metabolic parameters were obtained by analyzing the fasting blood samples after an overnight fast of at least 8 hours during the menstrual period. The assay methods of hormonal and metabolic parameters have been detailed in a previous study [25]. The intra-assay variation was less than 10% and the inter-assay variation was less than 10% for all the assay methods.…”

Section: Anthropometric and Laboratory Measurementsmentioning

confidence: 99%

“…It has been reported that in the general female population, NC can predict MetS beyond the classical anthropometric parameters [12]. Since women with PCOS are more susceptible to metabolic abnormalities, compelling evidence has shown that NC was also closely associated with serum uric acid and insulin resistance in women with PCOS [13,14]. A recent study conducted in 200 Bangladeshi women found that in women with PCOS, NC may be a convenient method for assessing MetS [15].…”

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confidence: 99%

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Neck circumference is independently associated with metabolic syndrome in women with polycystic ovary syndrome

et al. 2022

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Recent compelling evidence has shown that neck circumference (NC), as a reliable and convenient anthropometric index, has better predictive values of hyperuricemia and insulin resistance in women with polycystic ovary syndrome (PCOS) compared with traditional anthropometric measurements. Since both PCOS and metabolic syndrome (MetS) share similar characteristics and affect long-term health of women, we conducted this cross-sectional study to explore the correlation of NC with MetS and metabolic risk factors. Anthropometric parameters, blood pressure, glycemic and lipid profile of 633 PCOS and 2,172 non-PCOS women from January 2018 to June 2021 were analyzed. The results showed that the prevalence of MetS was 28.0% and 9.4% in PCOS and non-PCOS women, respectively. The prevalence of MetS, hypertention, obesity, central obesity, hyperglycemia and dyslipidaemia was also significantly higher in both PCOS and non-PCOS women with larger NC. Additionally, logistic regression analysis showed that PCOS women in the highest quartile of NC had the highest prevalence of MetS (RR = 9.94, 95%CI: 2.41-40.99) after adjusting for confounding factors, while the association between NC and MetS was much attenuated after adjusting for confounding factors in non-PCOS women. Furthermore, we also identified that the optimal NC cutoff value was 33 cm in PCOS women for the prediction of MetS. The potential mechanism could be attributed to the increased release of adipokines and excessive free fatty acids release from subcutaneous adipose tissue, which consequently precipitate the development of MetS. In conclusion, NC was found to be positively and independently correlated with the prevalence of MetS.

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“…The receiver operating characteristic (ROC) curve was obtained (MedCalc V19) for the display of the constructed models, then the area under the curve (AUC) was used to designate the ROC effect. Moreover, the screening efficacy of potential biomarkers for presence in COVID-19 patients was assessed with the misdiagnosis rate, the missed diagnosis rate, and the Youden Index (YI) ( 23 ). All the screening models were tested using five-fold cross validation as internal validations.…”

Section: Methodsmentioning

confidence: 99%

Alterations of Urinary Microbial Metabolites and Immune Indexes Linked With COVID-19 Infection and Prognosis

et al. 2022

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Coronavirus disease 2019 (COVID-19) has evolved into an established global pandemic. Metabolomic studies in COVID-19 patients is worth exploring for further available screening methods. In our study, we recruited a study cohort of 350 subjects comprising 248 COVID-19 patients (161 non-severe cases, 60 asymptomatic cases, and 27 severe cases) and 102 healthy controls (HCs), and herein present data with respect to their demographic features, urinary metabolome, immunological indices, and follow-up health status. We found that COVID-19 resulted in alterations of 39 urinary, mainly microbial, metabolites. Using random forest analysis, a simplified marker panel including three microbial metabolites (oxoglutaric acid, indoxyl, and phenylacetamide) was constructed (AUC=0.963, 95% CI, 0.930-0.983), which exhibited higher diagnostic performance than immune feature-based panels between COVID-19 and HC groups (P<0.0001). Meanwhile, we observed that urine metabolic markers enabled discriminating asymptomatic patients (ASY) from HCs (AUC = 0.981, 95% CI, 0.946-0.996), and predicting the incidence of high-risk sequalae in COVID-19 individuals (AUC=0.931, 95% CI, 0.877-0.966). Co-expression network analysis showed that 13 urinary microbial metabolites (e.g., oxoglutaric acid) were significantly correlated with alterations of CD4+, CD3+, and CD8+ T-cells, as well as IFN-γ, IL-2 and IL-4 levels, suggesting close interactions between microbial metabolites and host immune dysregulation in COVID-19. Taken together, our findings indicate that urinary metabolites may have promising potential for screening of COVID-19 in different application scenarios, and provide a new entry point to understand the microbial metabolites and related immune dysfunction in COVID-19.

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Neck Circumference Is Associated With Hyperuricemia in Women With Polycystic Ovary Syndrome

Cited by 12 publications

References 49 publications

Serum uric acid/creatinine ratio and free androgen index are synergistically associated with increased risk of polycystic ovary syndrome in obese women

Serum uric acid/creatinine ratio and free androgen index are synergistically associated with increased risk of polycystic ovary syndrome in obese women

Neck circumference is independently associated with metabolic syndrome in women with polycystic ovary syndrome

Alterations of Urinary Microbial Metabolites and Immune Indexes Linked With COVID-19 Infection and Prognosis

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