Neck circumference as reliable predictor of mechanical ventilation support in adult inpatients with COVID‐19: A multicentric prospective evaluation

Bella, Stefano Di; Cesareo, Roberto; Cristofaro, Paolo De; Palermo, Andrea; Sanson, Gianfranco; Roman-Pognuz, Erik; Zerbato, Verena; Manfrini, Silvia; Giacomazzi, Donatella; Bo, Eugenia Dal; Sambataro, Gianluca; Macchini, Elisabetta; Quintavalle, Francesco; Campagna, Giuseppe; Masala, Renato; Ottaviani, Luigi; Borgo, Cosmo Del; Leonetti, Frida; Berlot, Giorgio; Luzzati, Roberto

doi:10.1002/dmrr.3354

Cited by 13 publications

(7 citation statements)

References 35 publications

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“…Other measures of adiposity (such as waist circumference and neck circumference) were not available. In a recent multicentre study performed in Italy, neck circumference was significantly associated with the need for invasive mechanical ventilation in COVID‐19 patients 25 . Thirdly, and despite our adjustment for a large number of variables, residual confounding cannot be ruled out.…”

Section: Discussionmentioning

confidence: 85%

Characteristics and outcomes ofCOVID‐19 in hospitalized patients with and without diabetes

Al‐Salameh

Lanoix

Bennis

et al. 2020

Diabetes Metabolism Res

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Aims Coronavirus disease 2019 (COVID‐19) is a rapidly progressing pandemic, with four million confirmed cases and 280,000 deaths at the time of writing. Some studies have suggested that diabetes is associated with a greater risk of developing severe forms of COVID‐19. The primary objective of the present study was to compare the clinical features and outcomes in hospitalized COVID‐19 patients with vs. without diabetes. Methods All consecutive adult patients admitted to Amiens University Hospital (Amiens, France) with confirmed COVID‐19 up until April 21 st , 2020, were included. The composite primary endpoint comprised admission to the intensive care unit (ICU) and death. Both components were also analyzed separately in a logistic regression analysis and a Cox proportional hazards model. Results A total of 433 patients (median age: 72; 238 (55%) men; diabetes: 115 (26.6%)) were included. Most of the deaths occurred in non‐ICU units and among older adults. Multivariate analyses showed that diabetes was associated neither with the primary endpoint (odds ratio (OR): 1.12; 95% confidence interval (CI): 0.66‐1.90) nor with mortality (hazard ratio: 0.73; 95%CI: 0.40‐1.34) but was associated with ICU admission (OR: 2.06; 95%CI 1.09‐3.92, p=0.027) and a longer length of hospital stay. Age was negatively associated with ICU admission and positively associated with death. Discussion Diabetes was prevalent in a quarter of the patients hospitalized with COVID‐19; it was associated with a greater risk of ICU admission but not with a significant elevation in mortality. Further investigation of the relationship between COVID‐19 severity and diabetes is warranted. This article is protected by copyright. All rights reserved.

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Section: Discussionmentioning

confidence: 85%

Characteristics and outcomes ofCOVID‐19 in hospitalized patients with and without diabetes

Al‐Salameh

Lanoix

Bennis

et al. 2020

Diabetes Metabolism Res

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“…A total of 1595 studies were screened; only thirty observational studies met the final inclusion criteria in the analysis ( Figure 1 ; Table A1 ) [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. Main study characteristics of COPD and asthma analysis cohorts are abridged in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

Assessment of the Association of COPD and Asthma with In-Hospital Mortality in Patients with COVID-19. A Systematic Review, Meta-Analysis, and Meta-Regression Analysis

Reyes

Hache-Marliere

Karamanis

et al. 2021

JCM

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Together, chronic obstructive pulmonary disease (COPD) and asthma account for the most common non-infectious respiratory pathologies. Conflicting preliminary studies have shown varied effect for COPD and asthma as prognostic factors for mortality in coronavirus disease 2019 (COVID-19). The aim of this study was to explore the association of COPD and asthma with in-hospital mortality in patients with COVID-19 by systematically reviewing and synthesizing with a meta-analysis the available observational studies. MEDLINE, Scopus, and medRxiv databases were reviewed. A random-effects model meta-analysis was used, and I-square was utilized to assess for heterogeneity. In-hospital mortality was defined as the primary endpoint. Sensitivity and meta-regression analyses were performed. Thirty studies with 21,309 patients were included in this meta-analysis (1465 with COPD and 633 with asthma). Hospitalized COVID-19 patients with COPD had higher risk of death compared to those without COPD (OR: 2.29; 95% CI: 1.79–2.93; I2 59.6%). No significant difference in in-hospital mortality was seen in patients with and without asthma (OR: 0.87; 95% CI: 0.68–1.10; I2 0.0%). The likelihood of death was significantly higher in patients with COPD that were hospitalized with COVID-19 compared to patients without COPD. Further studies are needed to assess whether this association is independent or not. No significant difference was demonstrated in COVID-19-related mortality between patients with and without asthma.

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“…Neck circumference (NC) is a convenient anthropometric parameter that reflects the subcutaneous fat tissue of the upper body ( 18 ). Our previous study found that in PCOS women with obesity, the prevalence of hyperuricemia was approximately threefold higher than that in PCOS women with normal BMI ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Neck Circumference Is Associated With Hyperuricemia in Women With Polycystic Ovary Syndrome

et al. 2021

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ObjectiveTo evaluate the association between neck circumference (NC) and hyperuricemia in women with polycystic ovary syndrome (PCOS).MethodsThis is a cross-sectional study that recruited 601 women with PCOS from January 2018 to January 2021. PCOS was diagnosed according to the Rotterdam definition. Hyperuricemia was defined as serum uric acid level of at least 357 μmol/L.ResultsPCOS females with hyperuricemia had significantly greater values of NC, body mass index (BMI), waist circumference (WC) and hip circumference (HC). NC was positively associated with serum uric acid levels, with a standardized regression coefficient of 0.34 after adjusting for confounding factors. Furthermore, logistic regression analysis showed that NC was significantly associated with an increased risk of hyperuricemia, with an adjusted odds ratio of 1.36. The associations between NC and serum uric acid levels were more considerable in those with medium/high BMI (BMI ≥ 21.63 kg/m2), all ranges of WC or medium/high HC (HC ≥ 90 cm). The optimal cut-off point of NC in predicting hyperuricemia was 32.0 cm (Youden index = 0.48), with the sensitivity and negative predictive value of 84.81% and 92.08%, respectively.ConclusionsNC was positively correlated with serum uric acid levels and the prevalence of hyperuricemia in women with PCOS. Therefore, we suggest NC as a simple, novel, and reliable anthropometric measure to be used in the routine clinical assessment of women with PCOS to screen those at high risk of hyperuricemia.

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Neck circumference as reliable predictor of mechanical ventilation support in adult inpatients with COVID‐19: A multicentric prospective evaluation

Cited by 13 publications

References 35 publications

Characteristics and outcomes ofCOVID‐19 in hospitalized patients with and without diabetes

Characteristics and outcomes ofCOVID‐19 in hospitalized patients with and without diabetes

Assessment of the Association of COPD and Asthma with In-Hospital Mortality in Patients with COVID-19. A Systematic Review, Meta-Analysis, and Meta-Regression Analysis

Neck Circumference Is Associated With Hyperuricemia in Women With Polycystic Ovary Syndrome

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