Nebulized oil-in-water nanoemulsion mists for pulmonary delivery: development, physico-chemical characterization and<i>in vitro</i>evaluation

Nesamony, Jerry; Shah, Ishan S; Kalra, Ashish; Jung, Rose

doi:10.3109/03639045.2013.814065

Cited by 30 publications

(25 citation statements)

References 63 publications

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“…Due to constraint with stability of the nanoemulsion, they are usually filtersterilized using 0.22-μm filters. The sterilization of the nanoemulsion is validated by direct spectroscopic method to assess any potential microbial contamination and by plating method to check for microbial growth (15).…”

Section: Sterilitymentioning

confidence: 99%

Nanoemulsions in Translational Research—Opportunities and Challenges in Targeted Cancer Therapy

et al. 2014

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Abstract. Nanoemulsion dosage form serves as a vehicle for the delivery of active pharmaceutical ingredients and has attracted great attention in drug delivery and pharmacotherapy. In particular, nanoemulsions act as an excellent vehicle for poorly aqueous soluble drugs, which are otherwise difficult to formulate in conventional dosage forms. Nanoemulsions are submicron emulsions composed of generally regarded as safe grade excipients. Particle size at the nanoscale and larger surface area lead to some very interesting physical properties that can be exploited to overcome anatomical and physiological barriers associated in drug delivery to the complex diseases such as cancer. Along these lines, nanoemulsions have been engineered with specific attributes such as size, surface charge, prolonged blood circulation, target specific binding ability, and imaging capability. These attributes can be tuned to assist in delivering drug/imaging agents to the specific site of interest, based on active and passive targeting mechanisms. This review focuses on the current state of nanoemulsions in the translational research and its role in targeted cancer therapy. In addition, the production, physico-chemical characterization, and regulatory aspects of nanoemulsion are addressed.

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Section: Sterilitymentioning

confidence: 99%

Nanoemulsions in Translational Research—Opportunities and Challenges in Targeted Cancer Therapy

et al. 2014

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“…Therefore, each nanoemulsion component was decreased to the minimum. To date, all reported nanoemulsion formulations [40][41][42] have been prepared using a high concentration of surfactant (about 10% w/w of the formulation or above), which is not suitable for the lungs according to the FDA (US Food and Drug Administration). Whereas, in this work, the amount of Tween 80 (surfactant) used was ten to thirty times lower than the levels used in other reported work, which could be suitable and safer for the respiratory system.…”

Section: Discussionmentioning

confidence: 99%

Development and evaluation of nanoemulsion and microsuspension formulations of curcuminoids for lung delivery with a novel approach to understanding the aerosol performance of nanoparticles

ayoub

Gopalan

Najafzadeh

et al. 2019

International Journal of Pharmaceutics

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Extensive research has demonstrated the potential effectiveness of curcumin against various diseases, including asthma and cancers. However, few studies have used liquid-based vehicles in the preparation of curcumin formulations. Therefore, the current study proposed the use of nanoemulsion and microsuspension formulations to prepare nebulised curcuminoid for lung delivery. Furthermore, this work expressed a new approach to understanding the aerosol performance of nanoparticles compared to microsuspension formulations. The genotoxicity of the formulations was also assessed. Curcuminoid nanoemulsion formulations were prepared in three concentrations (100, 250 and 500 µg/ml) using limonene and oleic acid as oil phases, while microsuspension solutions were prepared by suspending curcuminoid particles in isotonic solution (saline solution) of 0.02% Tween 80. The average fine particle fraction (FPF) and mass median aerodynamic diameter (MMAD) of the nebulised microsuspension formulations ranged from 26% and 7.1 µm to 40% and 5.7 µm, for 1000 µg/ml and 100 µg/ml respectively. In a comparison of the low and high drug concentrations of the nebulised nanoemulsion, the average FPF and MMAD of the nebulised nanoemulsion formulations prepared with limonene oil ranged from 50% and 4.6 µm to 45% and 5.6 µm, respectively; whereas the FPF and MMAD of the nebulised nanoemulsion prepared with oleic acid oil ranged from 46% and 4.9 µm to 44% and 5.6 µm, respectively. The aerosol performance of the microsuspension formulations were concentration dependent, while the nanoemulsion formulations did not appear to be dependent on the curcuminoids concentration. The performance and genotoxicity results of the formulations suggest the suitability of these preparations for further inhalation studies in animals.

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“…This could be due to the different experimental conditions used in DLS and TEM. In TEM, the oil droplets spread on to the surface of the grids and this process is facilitated by the low interfacial tension which further results in coalescence and the formation of larger structures as evident from the images [147].…”

Section: Histological Evaluation In Bovine Corneamentioning

confidence: 99%

Development and Evaluation of a Novel Microemulsion of Dexamethasone and Tobramycin for Topical Ocular Administration

Bachu

Stepanski

Alzhrani

et al. 2018

Journal of Ocular Pharmacology and Therapeutics

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Nebulized oil-in-water nanoemulsion mists for pulmonary delivery: development, physico-chemical characterization andin vitroevaluation

Abstract: The developed formulation could be used as an inhalation for delivering material possessing poor water solubility into the lungs.

Cited by 30 publications

References 63 publications

Nanoemulsions in Translational Research—Opportunities and Challenges in Targeted Cancer Therapy

Nanoemulsions in Translational Research—Opportunities and Challenges in Targeted Cancer Therapy

Development and evaluation of nanoemulsion and microsuspension formulations of curcuminoids for lung delivery with a novel approach to understanding the aerosol performance of nanoparticles

Development and Evaluation of a Novel Microemulsion of Dexamethasone and Tobramycin for Topical Ocular Administration

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