Nebulized Isoetharine and Fenoterol in Acute Attacks of Asthma

König, Peter

doi:10.1001/archinte.1983.00350070081015

Arch Intern Med

1983

DOI: 10.1001/archinte.1983.00350070081015

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Nebulized Isoetharine and Fenoterol in Acute Attacks of Asthma

Peter König¹

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1985

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Cited by 8 publications

References 18 publications

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Fenoterol: A Beta₂‐adrenergic Agonist for Use in Asthma; Pharmacology, Pharmacokinetics, Clinical Efficacy and Adverse Effects

Svedmyr

1985

Pharmacotherapy

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Fenoterol (hydroxyphenylorciprenaline) is chemically closely related to metaproterenol (orciprenaline). It has a higher bronchodilating potency than metaproterenol, albuterol (salbutamol in Europe) or terbutaline. The beta 2 selectivity of fenoterol at normal oral and inhaled doses is the same as for albuterol and terbutaline. Its pharmacodynamic effects are similar to those of other selective beta 2-adrenoceptor agonists. It has a high first-pass metabolism. The long half-life previously reported in the literature (7 hours) is mainly the half-life of inactive fenoterol metabolites. The duration of action at equipotent bronchodilating doses seems to be the same as for albuterol and terbutaline, and not longer, as previously reported. Inhalation of beta-adrenoceptor agonists is the superior route of administration. Side effects do not usually occur at normal therapeutic doses. One puff of fenoterol (200 micrograms) is about equipotent to 2 puffs of albuterol (2 X 100 micrograms) or 2 puffs of terbutaline (2 X 250 micrograms) with the same duration of effect. In patients who overdose with the metered-dose inhaler (MDI), side effects occur at half the number of puffs with fenoterol. Dosage for an acute attack in children is 1 puff (200 micrograms), repeated within 5 minutes if necessary; in adults 1-3 puffs can be given. For maintenance therapy, the dose in adults is 1-2 puffs 2-4 times daily, while in children 1 puff at night and 1 in the morning may be sufficient. The usual oral dosage has been 5-10 mg 3 times daily.

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Fenoterol: A Beta₂‐adrenergic Agonist for Use in Asthma; Pharmacology, Pharmacokinetics, Clinical Efficacy and Adverse Effects

Svedmyr

1985

Pharmacotherapy

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Comparison of bronchodilator responses with bitolterol mesylate solution with the use of two different nebulizer systems in asthma

et al. 1986

Journal of Allergy and Clinical Immunology

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Therapy of acute asthma

McFadden

1989

Journal of Allergy and Clinical Immunology

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Nebulized Isoetharine and Fenoterol in Acute Attacks of Asthma

Cited by 8 publications

References 18 publications

Fenoterol: A Beta₂‐adrenergic Agonist for Use in Asthma; Pharmacology, Pharmacokinetics, Clinical Efficacy and Adverse Effects

Fenoterol: A Beta₂‐adrenergic Agonist for Use in Asthma; Pharmacology, Pharmacokinetics, Clinical Efficacy and Adverse Effects

Comparison of bronchodilator responses with bitolterol mesylate solution with the use of two different nebulizer systems in asthma

Therapy of acute asthma

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Product

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Nebulized Isoetharine and Fenoterol in Acute Attacks of Asthma

Cited by 8 publications

References 18 publications

Fenoterol: A Beta2‐adrenergic Agonist for Use in Asthma; Pharmacology, Pharmacokinetics, Clinical Efficacy and Adverse Effects

Fenoterol: A Beta2‐adrenergic Agonist for Use in Asthma; Pharmacology, Pharmacokinetics, Clinical Efficacy and Adverse Effects

Comparison of bronchodilator responses with bitolterol mesylate solution with the use of two different nebulizer systems in asthma

Therapy of acute asthma

Contact Info

Product

Resources

About

Fenoterol: A Beta₂‐adrenergic Agonist for Use in Asthma; Pharmacology, Pharmacokinetics, Clinical Efficacy and Adverse Effects

Fenoterol: A Beta₂‐adrenergic Agonist for Use in Asthma; Pharmacology, Pharmacokinetics, Clinical Efficacy and Adverse Effects