Comparison of bronchodilator responses with bitolterol mesylate solution with the use of two different nebulizer systems in asthma

Azelastine hydrochloride, chemically known as 1(2H)-phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepine-4-yl)-, monohydrochloride, is a novel, orally effective, long-acting, antiallergic/antiasthmatic agent. The ability of azelastine and selected antiallergic drugs to inhibit SRS-A (leukotriene)-mediated acute lung anaphylaxis in guinea pigs (Konzett-Rossler method) was investigated. Azelastine and ketotifen were administered p.o. 2 and 24 h before antigen challenge; disodium cromoglycate (DSCG) was administered i.v. immediately before antigen challenge. The oral dose of azelastine required to inhibit leukotriene-mediated allergic bronchospasm by 50% (ID50: mg/kg) was 0.063 at 2 h and 0.120 at 24 h. Ketotifen at a dose of 0.05 to 10 mg/kg at 2 and 24 h, p.o., as well as DSCG at a dosage of 0.3 to 10 mg/kg at 0 min, i.v., produced weak, inconsistent and nondose-related antianaphylactic effects. Azelastine is an orally effective and long-acting inhibitor of in vivo synthesis and/or release of leukotrienes.

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Relative Amount of Albuterol Delivered to Lung Receptors from a Metered-dose Inhaler and Nebulizer Solution

Blake

Hoppe

Harman

et al. 1992

Chest

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Comparison of bronchodilator responses with bitolterol mesylate solution with the use of two different nebulizer systems in asthma

Cited by 7 publications

References 16 publications

Multicenter study of bitolterol and isoproterenol nebulizer solutions in nonsteroid-using patients

Multicenter study of bitolterol and isoproterenol nebulizer solutions in nonsteroid-using patients

Inhibition of Leukotriene (SRS‐A)‐Mediated Acute Lung Anaphylaxis by Azelastine in Guinea Pigs

Relative Amount of Albuterol Delivered to Lung Receptors from a Metered-dose Inhaler and Nebulizer Solution

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