Nebivolol alleviates aortic remodeling through eNOS upregulation and inhibition of oxidative stress in <scp>l</scp>-NAME-induced hypertensive rats

Wang, Yan; Zhang, Fei; Liu, Yu; Yin, Shi; Pang, Xue-Fen; Liu, Zhidong; Wei, Zehui

doi:10.1080/10641963.2017.1306539

Cited by 28 publications

(15 citation statements)

References 55 publications

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“…β3 AR s are upregulated in the myometrium during pregnancy, potentially heightening this effect. Nebivolol further enhances endothelial nitric oxide synthase ( eNOS ) expression and activity . This resulting surge of nitric oxide increases total protein S‐nitrosations ( SNO s), promoting SNO ‐mediated myometrial smooth muscle relaxation .…”

Section: Discussionmentioning

confidence: 99%

“…Nebivolol further enhances endothelial nitric oxide synthase (eNOS) expression and activity. 11 This resulting surge of nitric oxide increases total protein S-nitrosations (SNOs), 12 promoting SNO-mediated myometrial smooth muscle relaxation. 9 Inhibition of S-nitrosoglutathione reductase (GSNOR) also increases nitric oxide availability, which relaxes myometrial tissue 6 ; however, nebivolol does not inhibit the SNO-metabolizing enzymes GSNOR or thioredoxin reductase (TrxR) BARNETT AND BUXTON | 6393 N = 4), or mouse ( Figure 1B), myometrium.…”

Section: Nebivolol Decreases Uterine Force and Aucmentioning

confidence: 99%

“…Nebivolol also serves a lesser known secondary function as a β3AR agonist, 10 which facilitates vasodilation by increasing endothelial •NO-synthase (eNOS) activity and expression. 11 Nebivolol increases SNOs and has recently been reported as a GSNOR inhibitor, 12 which if true would further increase •NO concentration in the cell. The •NO-promoting effects of nebivolol makes it a candidate therapeutic for inotropic muscle conditions other than vascular smooth muscle disease, such as sPTL, where SNOs are decreased.…”

Section: Introductionmentioning

confidence: 99%

“…Nebivolol is a third generation, FDA‐approved β1‐adregneric receptor (β1AR) antagonist commonly used for the treatment of heart failure. Nebivolol also serves a lesser known secondary function as a β3AR agonist, which facilitates vasodilation by increasing endothelial •NO‐synthase (eNOS) activity and expression . Nebivolol increases SNOs and has recently been reported as a GSNOR inhibitor, which if true would further increase •NO concentration in the cell.…”

Section: Introductionmentioning

confidence: 99%

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Hiding in Plain Sight: Nebivolol Exhibits Compelling Tocolytic Properties

Barnett

Buxton

2018

J Cellular Molecular Medi

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Preterm birth before 37 weeks of completed gestation results in numerous health consequences for the foetus. Preterm labour leads to preterm birth in over 50% of cases, and no FDA‐approved treatment can prevent labour or help a foetus remain in the womb until term. Examination of nitric oxide mediated relaxation signaling in the uterine smooth muscle reveals a role for protein S‐nitrosation. The recent discovery of upregulated S‐nitrosoglutathione reductase (GSNOR) in spontaneously preterm labouring women has emphasized the need to explore the function of S‐nitrosation regulation in the maintenance of uterine quiescence. Here we have examined the ability of nebivolol to relax uterine smooth muscle and tested recent claims that nebivolol is a GSNOR inhibitor. In uterine smooth muscle strips from both mouse and human, nebivolol relaxes oxytocin‐induced contractions in a dose dependent manner. Our data indicates that nebivolol has no effect on GSNOR activity, nor does nebivolol inhibit thioredoxin reductase, two of the major protein denitrosylases. The ability of nebivolol to relax uterine smooth muscle is likely the combined effects of increased nitric oxide synthase activity and β3‐adregnegic stimulation.

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Section: Discussionmentioning

confidence: 99%

Section: Nebivolol Decreases Uterine Force and Aucmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hiding in Plain Sight: Nebivolol Exhibits Compelling Tocolytic Properties

Barnett

Buxton

2018

J Cellular Molecular Medi

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“…NO is an important regulator of vascular tone and blood pressure. It has been reported that the pharmacological reduction of NO can lead to hypertension in normotensive rats (Raghavan and Dikshit, 2004;Wang et al, 2017). L-NAME administration decreases NO synthesis and develops hypertension in rats (Leo et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of antihypertensive and vasorelaxant effects of Heimia salicifolia (family: Lythraceae)

Guzmán-Hernández¹,

Segura-Cobos²,

Amato³

et al. 2018

Afr. J. Pharm. Pharmacol.

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There are reports of the presence of vasodilatory alkaloids in Heimia salicifolia extracts. The action mechanisms of the potential antihypertensive effect of such alkaloids have not however, been elucidated. The objective of the present study was to corroborate the antihypertensive and vasorelaxant activities of the isolated alkaloids from H. salicifolia, and to characterize their vasorelaxant actions. A chloroform extract (HSCE) was obtained from H. salicifolia. The alkaloids were separated by thin layer chromatography, extracted from silica gel, and evaluated using spectroscopy. The alkaloid with the most potent vasorelaxant activity was identified as lythrine. The antihypertensive effect of the HSCE was corroborated on normotensive rats and on animals with N ω -nitro-L-arginine-methyl ester (L-NAME) induced hypertension. The action mechanisms of the HSCE and lythrine were studied on isolated and perfused rat mesenteric vascular bed (MVB) preparations. HSCE administration produced a concentration-dependent relaxation, but in preparations without vascular endothelium, the relaxant response to HSCE was significantly diminished. In MVB preparations with intact vascular endothelium, pre-contracted with phenylephrine or L-NAME, perfusion with lythrine produced concentrationdependent relaxation; a similar effect was produced by acetylcholine. Wortmannin (phosphatidylinositol 3-kinase inhibitor) and methylene blue (guanylate cyclase inhibitor) decreased the relaxant effect of lythrine. These data suggest that the vascular relaxation induced by alkaloids isolated from H. salicifolia is dependent on the activation of the nitric oxide/guanylate cyclase pathway.

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Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin

Miller,

Harrison,

Cortopassi

et al. 2024

GeroScience

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Nebivolol alleviates aortic remodeling through eNOS upregulation and inhibition of oxidative stress in l-NAME-induced hypertensive rats

Abstract: Our data indicate a protective role of nebivolol on the high blood pressure and vascular remodeling induced by l-NAME. The beneficial vascular effect of nebivolol is mediated by the upregulation of eNOS and inhibition of oxidative stress.

Cited by 28 publications

References 55 publications

Hiding in Plain Sight: Nebivolol Exhibits Compelling Tocolytic Properties

Hiding in Plain Sight: Nebivolol Exhibits Compelling Tocolytic Properties

Evaluation of antihypertensive and vasorelaxant effects of Heimia salicifolia (family: Lythraceae)

Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin

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